Jpn. J. Infect. Dis., 58, 149-151, 2005

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Original Article

Spontaneous Resolution of Hemophagocytic Syndrome and Disseminated Intravascular Coagulation Associated with Parvovirus B19 Infection in a Previously Healthy Child

Zuhre Kaya*, Gulyuz Ozturk, Turkiz Gursel and Gulendam Bozdayi1

Department of Pediatric Hematology and 1Department of Microbiology, Gazi University Medical School, Ankara, Turkey

(Received August 30, 2004. Accepted January 28, 2005)

*Corresponding author: Mailing address: Birlik mahallesi 68. sokak No:16/4, Cankaya, Ankara 06610, Turkey. Tel: +90-312-495-4272, E-mail:

SUMMARY: A 10-year-old male with a brain abscess developed pancytopenia, liver dysfunction, disseminated intravascular coagulation (DIC) and decrease of immunoglobulin A (IgA) level during postoperative antibiotic and anticonvulsant therapy. A bone marrow examination revealed hemophagocytosis. Real-time PCR revealed parvovirus B19 infection. The hemophagocytic syndrome resolved without specific treatment. To our knowledge, this is the first report of a spontaneous resolution of parvovirus B19-associated hemophagocytic syndrome and DIC.

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