Jpn. J. Infect. Dis., 62 (4), 254-259, 2009

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Original Article

Genetic Changes of Coxsackievirus A16 and Enterovirus 71 Isolated from Hand, Foot, and Mouth Disease Patients in Toyama, Japan between 1981 and 2007

Masae Iwai*, Akio Masaki1, Sumiyo Hasegawa, Mayumi Obara, Eiji Horimoto, Kazuya Nakamura, Yuichi Tanaka2, Kyoko Endo3, Keiko Tanaka4, Junko Ueda4, Kimiyasu Shiraki5, Takeshi Kurata, and Takenori Takizawa

Department of Virology, Toyama Institute of Health, Toyama 939-0363; 1Masaki Hospital, Toyama 939-1654; 2Tonami Health Center, Toyama 939-1506; 3Takaoka Health Center, Toyama 933-8523; 4Toyama Prefectural Central Hospital, Toyama 930-8550; and 5Department of Virology, Toyama University, Toyama 930-0194, Japan

(Received January 16, 2009. Accepted April 16, 2009)

*Corresponding author: Mailing address: Department of Virology, Toyama Institute of Health, 17-1 Nakataikoyama, Imizu-shi, Toyama 939-0363, Japan. Tel: +81-766-56-8143, Fax: +81-766-56-7326, E-mail:

SUMMARY: We characterized the genetic diversity of the complete VP1 region of coxsackievirus A16 (CA16) and enterovirus 71 (EV71) isolated from patients with hand, foot, and mouth disease in Toyama from 1981 to 2007 to evaluate the relationship between epidemics and genetic changes. The predominant genogroups of CA16 changed from B to C in 1995-1998, and genogroup C further changed from subgenogroup C1 to C2 around 2002, and to C3 in 2005-2007. The subgenogroups of the EV71 isolates were classified into B1, B4, C1, and C3 in 1983-1994, and into C4 in 1997-2006. However, changes of the amino acid sequences of the VP1 regions of CA16 were restored, and those of the EV71 isolates were not observed among the same subgenogroups during this survey period, indicating that the prevalence that occurred at intervals of several years seemed to depend on an accumulating number of immunologically naive children, not viral antigenic changes.

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