Jpn. J. Infect. Dis., 62 (4), 312-314, 2009

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Short Communication

Plasmid-Mediated Quinolone Resistance in Salmonella Isolated from Patients with Overseas Travelers' Diarrhea in Japan

Masumi Taguchi*, Ryuji Kawahara, Kazuko Seto, Kiyoshi Inoue, Akihiro Hayashi1, Nobuaki Yamagata2, Kazumasa Kamakura2, and Etsurou Kashiwagi2

Osaka Prefectural Institute of Public Health, Osaka 537-0025; 1Yokohama Quarantine Station, Kanagawa 236-0011; and 2Kansai Airport Quarantine Station, Osaka 549-0011, Japan

(Received March 11, 2009. Accepted June 5, 2009)


*Corresponding author: Mailing address: Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. Tel: +81-6-6972-1321, Fax: +81-6-6972-0772, E-mail: mstaguch@iph.pref.osaka.jp


SUMMARY: Twenty-eight of the 302 Salmonella strains isolated from patients with overseas travelers' diarrhea who were examined at Kansai Airport Department Station during the 6-year period between 2001 and 2007 showed decreased susceptibility to both nalidixic acid (NA) and ciprofloxacin (CPFX) (MIC of NA, 16-64 μg/mL; MIC of CPFX, 0.064-2.0 μg/mL). These 28 strains revealed no variations in the quinolone resistance-determining region; however, 25 of the strains showed retention of the qnr gene. The qnr-retaining Salmonella belonged to 6 serotypes, and 21 and 4 of the 25 strains showed qnrS1 and qnrS2, respectively. The most common serovar was S. Corvallis (17 strains).


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