General features

Gene IDMYPE4140
TypeCDS
From545803
To547926
Strand+
General nametopA
DefinitionDNA topoisomerase I
nt length2124
aa length707
m.w.81232.34
COG[L] Replication, recombination and repair


Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value
mpneMPN261 topA DNA topoisomerase I 312256:3143916504.2e-94
mgengi|12044974 DNA topoisomerase I (topA) [Mycoplasma genitalium]6343.3e-99
mpulgi|15828942 DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING ENZYME) (SWIVELASE) [Mycoplasma pulmonis]3699.1e-104
mmobgi|47458917 DNA topoisomerase I [Mycoplasma mobile 163K]3603.4e-101
mmycgi|42561447 DNA topoisomerase I [Mycoplasma mycoides subsp. mycoides SC]2851.9e-78
mgalgi|31544838 TopA [Mycoplasma gallisepticum R]6202.3e-179
uuregi|13358155 DNA topoisomerase I [Ureaplasma urealyticum]5633.4e-162
phytgi|39938765 topoisomerase IA [Onion yellows phytoplasma]4126.2e-117
bsubgi|16078675 DNA topoisomerase I [Bacillus subtilis]4961.8e-141
cacegi|15895061 Topoisomerase I [Clostridium acetobutylicum]4561.5e-129
ecoligi|16129235 DNA topoisomerase I [Escherichia coli K12]3449.9e-96

*mpne, Mycoplasma pneumoniae; mgen, Mycoplasma genitalium; mpul, Mycoplasma pulmonis; mmob, Mycoplasma mobile; mmyc, Mycoplasma mycoides; mgal, Mycoplasma gallisepticum; uure, Ureaplasma urealyticum; phyt, ; bsub, Bacillus subtilis; cace, Clostridium acetobutylicum; ecoli, Escherichia coli K-12;

Pfam search result


ModelNo.DescriptionPosition (aa)ScoreE-value

Topoisom_bac1DNA topoisomerase134-554478.01.3e-140

Toprim1Toprim domain2-120134.82.7e-37

zf-C4_Topoisom2Topoisomerase DNA binding C4 zinc fin592-632, 636-675112.81.2e-30

DUF12721Protein of unknown function (DUF1272)590-652-11.00.22

BLAST search result (top 10 hits)

IDDescriptionScoreE-value
gi|26553866DNA topoisomerase I [Mycoplasma penetrans HF-2] 33920.0e+00
gi|13508000DNA topoisomerase I [Mycoplasma pneumoniae M129] 15944.5e-175
gi|12044974DNA topoisomerase I [synthetic Mycoplasma genitalium JCVI-1.0] 15156.9e-166
gi|7109696DNA topoisomerase I [Mycoplasma gallisepticum] 14986.0e-164
gi|28212484DNA topoisomerase I [Mycoplasma gallisepticum] 14914.6e-163
gi|31544838TopA [Mycoplasma gallisepticum R] 14904.9e-163
gi|13358155DNA topoisomerase I [Ureaplasma parvum serovar 14 str. ATCC 33697] 13671.1e-148
gi|170762408DNA topoisomerase I [Ureaplasma parvum serovar 6 str. ATCC 27818] 13661.5e-148
gi|188592653DNA topoisomerase I [Ureaplasma urealyticum serovar 10] 13221.6e-143
gi|188039254DNA topoisomerase I [Ureaplasma urealyticum serovar 8] 13221.7e-143


Maintained by Jun Ishikawa