General features

Gene IDMYPE6880
TypeCDS
From884863
To884015
Strand-
General namefolD
Definitionmethylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase
nt length849
aa length282
m.w.31096.04
COG[H] Coenzyme metabolism


Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value
mpneMPN017 mtd1 FolD bifunctional protein 18989:181801133.3e-27
mgengi|12044863 methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (folD) [Mycoplasma genitalium]1202.0e-29
mpulgi|15828729 FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] [Mycoplasma pulmonis]1211.5e-29
mmobgi|47458995 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Mycoplasma mobile 163K]1454.6e-37
mmycgi|42561283 methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase [Mycoplasma mycoides subsp. mycoides SC]1542.2e-39
mgalgi|31544918 FolD [Mycoplasma gallisepticum R]988.0e-23
uuregi|13357897 methylenetetrahydrofolate dehydrogenase [Ureaplasma urealyticum]801.8e-17
bsubgi|16079487 methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis]1921.9e-50
cacegi|15895353 Tetrahydrofolate dehydrogenase/cyclohydrolase, FolD [Clostridium acetobutylicum]2013.8e-53
ecoligi|16128513 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase [Escherichia coli K12]1644.7e-42

*mpne, Mycoplasma pneumoniae; mgen, Mycoplasma genitalium; mpul, Mycoplasma pulmonis; mmob, Mycoplasma mobile; mmyc, Mycoplasma mycoides; mgal, Mycoplasma gallisepticum; uure, Ureaplasma urealyticum; bsub, Bacillus subtilis; cace, Clostridium acetobutylicum; ecoli, Escherichia coli K-12;

Pfam search result


ModelNo.DescriptionPosition (aa)ScoreE-value

THF_DHG_CYH_C1Tetrahydrofolate dehydrogenase/cyclohyd119-278237.53.3e-68

THF_DHG_CYH1Tetrahydrofolate dehydrogenase/cyclohyd1-11684.44.1e-22

BLAST search result (top 10 hits)

IDDescriptionScoreE-value
gi|26554142methylenetetrahydrofolate dehydrogenase [Mycoplasma penetrans HF-2] 12831.7e-139
gi|30264256methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ... 5312.4e-52
gi|1885863175,10-methylenetetrahydrofolate dehydrogenase (NADP+), Methenyltetrahydrofolate c... 5312.7e-52
gi|196041527methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ... 5303.4e-52
gi|52141315bifunctional protein: methylenetetrahydrofolate dehydrogenase; methenyltetrahydr... 5303.4e-52
gi|49480926methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ... 5303.6e-52
gi|166981808methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ... 5251.2e-51
gi|42783300methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ... 5251.2e-51
gi|47569440methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ... 5241.4e-51
gi|146297145Methenyltetrahydrofolate cyclohydrolase [Caldicellulosiruptor saccharolyticus DS... 5232.3e-51


Maintained by Jun Ishikawa