PROTEIN KINASES
3-D Structure Summary


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Codes beginning PKxx are locally assigned; all others are PDB assignments. For structures with additional information, select a structure by its code. Legend to Information Content


cAMP Dependent Kinases

Code
Description

Open/Closed Conformation
PI
Year

Status
1CMK
Catalytic subunit monomer complexed with PKI(5-24), Pig heart. Phosphorylated. Myristylated, Iodinated. Resolution 2.9A Open conformation
Taylor
11/93
1ATP
Catalytic subunit monomer ternary complex with P KI(5-24), 2(Mn++) and ATP. Recombinant mouse. Phosphorylated. Resolution 2.2A Closed conformation
Taylor
01/93
1CDK
Catalytic subunit dimer complexed with PKI(5-24), 5-adenyl y-imido triphosphate, 2(Mn++) myristilated. Porcine heart. Phosphorylated. Resolution 2.0A Closed conformation
Huber
7/94
1APM
Catalytic subunit monomer complexed with PKI (5-24) and the detergent mega-8. Isoenzyme mutant with SER 139 replaced by ALA. Recombinant mouse. Phosphorylated Resolution 2.0A Closed conformation
Taylor
01/93
1CTP
Catalytic subunit monomer, complexed with PKI(5-24), myristylated. Pig. Phosphorylated. Iodinated. Resolution 2.9A Open conformation
Taylor
04/93
PK06
Catalytic subunit monomer complexed with PKI(5-24), octomer, and ADP Closed conformation
Taylor
unpublished
1STC
cAMP-dependent Protein Kinase
Bossemeyer
10/97
2CPK
Catalytic subunit monomer complexed with PKI(5-24) Recombinant mouse. Phosphorylated. Resolution 2.7A Closed conformation
Taylor
10/92
1YDR
Catalytic subunit monomer complexed with PKI(5-24), 3 1-(5-isoquinolinesulfonyl)-2-methylpiperazine. Phosphorylated. Resolution 2.2 A
Engh
7/96
1YDS
Catalytic subunit monomer complexed with PKI (5-24) [N-(2-methylamino)ethyl]-5-isoquinolinesulfonamide. Phosphorylated. Resolution 2.2 A
Engh
7/96
1YDT
Catalytic subunit monomer complexed with PKI(5-24), 3 N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline Phosphorylated. Resolution 2.3 A
Engh
07/96
1FMO
Polyhistidine-Tagged Recombinant Catalytic Subunit Of Camp-Depende Protein Kinase Complexed With The Peptide Inhibitor Pki(5-24) And Adenosine Complex
Taylor
01/98
1BKX
Catalytic subunit binary complex  with adenosine
Taylor
03/98
1RGS
Regulatory subunit, monomer, complex with cAMP. Recombinant bovine Resolution 2.8A
Taylor
06/95

Protein Kinase C

1PTQ
Cys2 activator binding domain monomer and 2(Zn++). Resolution 1.95A
Hurley
05/95
1PTR
Cys2 activator binding domain monomer complexed with Phorbol-13-Acetate and 2(Zn++).
Resolution 2.2A
Hurley
05/95

Phosphorylase Kinases

1PHK
Gamma subunit truncated (1-298) monomer complexed with 2(Mn++) and ATP. Rabbit muscle. Resolution 2.2A
Johnson
03/96

Calmodulin Kinases

1A06
Calcium calmodulin dependent protein kinase I
Kuriyan
12/97
1CDM
Calmodulin Complexed With Calmodulin-Binding Domain Of Calmodulin-Dependent Protein Kinase II
Quiocho
08/94
1CM1
Calmodulin chain A complexed with  Calmodulin-Dependent Protein Kinase II Fragment: Residues 290 - 314
Phillips Jr
03/98
1CM4
Calmodulin; Chain: A, C, E, G; complexed with Calmodulin-Dependent Protein Kinase II-; Chain: B, D, F, H; Fragment: Residues 290 - 314
Phillips Jr
03/98

Casein Kinases

1CSN
Binary complex of Casein Kinase-1 with MgATP
X.Cheng
04/95
2CSN
Casein kinase-1 catalytic core
X.Cheng
10/95
1A6O
Casein Kinase II, Alpha Subunit
K. Niefind
02/98

Cyclin Dependent Kinases

1HCK
Complexed w/wo ATP & Water. Recombinant human. Resolution 1.9A
Kim
6/96
1HCL
Monomer, uncomplexed. Recombinant human. Resolution 1.8A
Kim
6/96
1AQ1
Staurosporin complexed. Recombinant human. Resolution 2.0A
Endicott
8/97
1FIN
Dimer complexed with cyclin and ATP unphosphorylated Resolution 2.3A
Pavletich
07/96
PK04
Complex with cyclin. Phosphorylated
Pavletich
provided
1JSU
Complex with cyclin an P27 Phosphorylated
Pavletich
07/97

Tyrosine Kinases

1IRK
Insulin receptor tyrosine kinase domain
Hendrickson
01/94
1CSY Syk Tyrosine Kinase C-Terminal Sh2 Domain Complexed With A Phosphopeptidefrom The Gamma Chain Of The High Affinity Immunoglobin G Receptor (NMR) Dalgarno 11/96
1CWE P56Lck Tyrosine Kinase; Chain: A, C; Fragment: Phosphotyrosine Recognition Domain Sh2 Mikol 12/96
1BLJ
P55 Blk Protein Tyrosine Kinase; Chain: Null; Fragment: Sh2 Domain, Src
Homology 2;
Farmer
03/97
1IR3
Phosphorylated insulin receptor tyrosine kinase domain in complex w/peptide substrate
Hubbard
09/97
1AGW
1FGI
1FGK
FGF Receptor tyrosine kinase domain
Hubbard
hold till 03/98
2HCK
Haematopoetic Cell Kinase (Hck) monomer complexed with SH2-SH3 regulatory tail
Kuriyan
06/97
1AD5
Haematopoetic Cell Kinase (Hck) monomer complexed with SH2-SH3 regulatory tail and AMP and PNP
Kuriyan
07/97
1FMK
c-Src tyrosine kinase monomer complex of regulatory, kinase and carboxy terminal tail
Harrison
07/97
2PTK
Tyrosine-Protein Kinase Transforming Protein Src; Chain: Null; Fragment:
Sh3/Sh2/Kinase/C-Terminal Tail
Wierenga
12/97
3LCK
Human Lymphocyte Kinase
Hendrickson
4/97
1AOT
Fyn Protein-Tyrosine Kinase; Chain: F; Fragment: Sh2 Domain; Synonym: Src Homology 2 Domain (NMR)
Campbell
01/98

Mitogen Activated Kinases

1ERK
Mitogen activated protein kinase (apo-form)
Goldsmith
06/96
1P38
Mitogen activated protein kinase (apo-form)
Goldsmith
01/98
1WFC
Apo, Unphosphorylated, P38 Mitogen Activated Protein Kinase
Wilson
09/97
1IAN
Human p38 mitogen-activated protein (MAP) kinase in complex with a potent and highly specific pyridinyl-imidazole inhibitor 2.0A
Tong
05/98

Twitchen Kinases

1KOA
C. Elegans twitchen kinase fragment
Kemp
06/97
1KOB
Aplysia twitchen kinase fragment
Kemp
06/97


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Last modified Wednesday, 31 December 2069 by Anonymous