Snapshot - 1AD5

MOL_ID: 1; MOLECULE: HAEMATOPOETIC CELL KINASE HCK; CHAIN: A, B; FRAGMENT: SH3-SH2-KINASE-REGULATORY TAIL; EC: 2.7.1.112; ENGINEERED: YES; BIOLOGICAL_UNIT: MONOMER

Compound summary followed by details of each entity.

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      Resolution: 2.60 Å                        Deposition Date: 20-FEB-97

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; 
              ORGANISM_COMMON: HUMAN; EXPRESSION_SYSTEM: 
              SPODOPTERA FRUGIPERDA INSECT CELLS; 
              EXPRESSION_SYSTEM_CELL_LINE: SF9; 
              EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; 
              EXPRESSION_SYSTEM_GENE: HUMAN HCK 
              
      Functional Class: TYROSINE-PROTEIN KINASE                 

      Authors: F.SICHERI,I.MOAREFI,J.KURIYAN 
               
      Primary Citation: F.SICHERI,I.MOAREFI,J.KURIYAN CRYSTAL STRUCTURE OF 
                        THE SRC FAMILY TYROSINE KINASE HCK NATURE V. 385 
                        602 1997 ASTM NATUAS UK ISSN 0028-0836 0006 
                        
      Number of Entities: 2

Entity 1AD5:A

      Type: Protein                  Molecular Weight: 57850
      Number of Residues: 438
      Number of Alpha: 10            Content of Alpha: 24.89
      Number of Beta: 20             Content of Beta: 20.55

      Secondary structure by segment:

     LELELELELELELHLELELELELHLELELELELELHLELELEHLHLELELHLHLHLHLHL

      Sequence and secondary structure:

   1 EDIIVVALYD YEAIHHEDLS FQKGDQMVVL EESGEWWKAR SLATRKEGYI 
        EEEESS  B   SSSB   BTTTTEEEE  B TTTEEEEE ETTTT EEEE 

  51 PSNYVARVDS LETEEWFFKG ISRKDAERQL LAPGNMLGSF MIRDSETTKG 
     EGGGEEEGGG GGGGGGEEGG TTHHHHHHHH TTGGGGGGTE EEEE SSTTT 

 101 SYSLSVRDYD PRQGDTVKHY KIRTLDNGGF YISPRSTFST LQELVDHYKK 
     TEEEEEEEEE TTBSEEEEEE EEEE SSS E ESTTTT BST HHHHHHHHHH 

 151 GNDGLCQKLS VPCMSSKPQK PWEKDAWEIP RESLKLEKKL GAGQFGEVWM 
     T SSSSS    SB           TTTTSEET GGGEEE EE  B  SSEEEEE 

 201 ATYNKHTKVA VKTMKPGSMS VEAFLAEANV MKTLQHDKLV KLHAVVTKEP 
     EEETTTEEEE EEEETTTTST HHHHHHHHHH HGGT TTTB   B EEE SSS 

 251 IYIITEFMAK GSLLDFLKSD EGSKQPLPKL IDFSAQIAEG MAFIEQRNYI 
     EEEEEE TTT EEHHHHHHHH HHHGGGHHHH HHHHHHHHHH HHHHHHTTT  

 301 HRDLRAANIL VSASLVCKIA DFGLARVGAK FPIKWTAPEA INFGSFTIKS 
      S  TGGGEE ETTTT EEE         SSS STGGGGGHHH HHHT  THHH 

 351 DVWSFGILLM EIVTYGRIPY PGMSNPEVIR ALERGYRMPR PENCPEELYN 
     HHHHHHHHHH HHHGGGT SS SS TGHHHHH HHHTTT     TGGGGHHHHH 

 401 IMMRCWKNRP EERPTFEYIQ SVLDDFYTAT ESQ*QQQP 
     HHHHHTTSTG GGT THHHHH HHHHGGGGGG GGTS     



Entity 1AD5:B

      Type: Protein                  Molecular Weight: 57850
      Number of Residues: 438
      Number of Alpha: 10            Content of Alpha: 25.34
      Number of Beta: 21             Content of Beta: 20.09

      Secondary structure by segment:

     LELELELELELELHLELELELELELHLELELELELELHLELELEHLHLELELHLHLHLHL
     HL

      Sequence and secondary structure:

   1 EDIIVVALYD YEAIHHEDLS FQKGDQMVVL EESGEWWKAR SLATRKEGYI 
        EEEESS  B   SSSB   BTTTTEEEE  B TTTEEEEE ETTTT EEEE 

  51 PSNYVARVDS LETEEWFFKG ISRKDAERQL LAPGNMLGSF MIRDSETTKG 
     EGGGEEEGGG GGGGGGEEGG TTHHHHHHHH TTGGGGGGTE EEEE SSTTT 

 101 SYSLSVRDYD PRQGDTVKHY KIRTLDNGGF YISPRSTFST LQELVDHYKK 
     TEEEEEEEET TTT EEEEEE E EE SSS E ESTTTT BST HHHHHHHHHH 

 151 GNDGLCQKLS VPCMSSKPQK PWEKDAWEIP RESLKLEKKL GAGQFGEVWM 
     T SSSSS    SB           TTTTSEET GGGEEE EE  B  SSEEEEE 

 201 ATYNKHTKVA VKTMKPGSMS VEAFLAEANV MKTLQHDKLV KLHAVVTKEP 
     EEETTTEEEE EEEETTTTST HHHHHHHHHH HHHT TTTB   B EEE SSS 

 251 IYIITEFMAK GSLLDFLKSD EGSKQPLPKL IDFSAQIAEG MAFIEQRNYI 
     EEEEEE TTT EEHHHHHHHH HHHGGGHHHH HHHHHHHHHH HHHHHHTTT  

 301 HRDLRAANIL VSASLVCKIA DFGLARVGAK FPIKWTAPEA INFGSFTIKS 
      S  TGGGEE ETTTT EEE         SSS  TGGGGGHHH HHHT  THHH 

 351 DVWSFGILLM EIVTYGRIPY PGMSNPEVIR ALERGYRMPR PENCPEELYN 
     HHHHHHHHHH HHHGGGT SS SS TGHHHHH HHHTTT     TGGGGHHHHH 

 401 IMMRCWKNRP EERPTFEYIQ SVLDDFYTAT ESQ*QQQP 
     HHHHHTTSTG GGT THHHHH HHHHGGGGGG GGTS