1APM

cAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37)

Recombinant Mouse (Mus musculus) Catalytic Subunit (Alpha Isozyme) SER 139 --> ALA Mutant Complex with the Peptide Inhibitor PKI(5-24) and the Detergent MEGA-8



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Synopsis

Standard Protein Kinase catalytic core in an open conformation. The detergent is shown in green and 3 phosphate groups in grey.

References

[1] Knighton DR; Bell SM; Zheng J; Ten Eyck LF; Xuong N-H; Taylor SS; Sowadski JM (1993) 2.0 Angstrom refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. Acta Cryst D49, pp. 357-361.

[2] Zheng J; Knighton DR; Ten Eyck LF; Karlsson R; Xuong N-H; Tayor SS; Sowadski JM (1993) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 32(9):2154-61 [Abstract]

Walk Through

Sequence Information


Last modified Wednesday, 30 July 1997 by Phil Bourne