Catalytic Subunit Complex with the Peptide Inhibitor PKI(5-24) and MnATP :
A Ternary Complex of cAPK

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Protein kinase catalytic domain with the 20 peptide inhibitor shown in yellow. The ATP is shown in dark yellow and the two manganese ions in green. Phosphates are in purple.


[1] Taylor SS; Radzio-Andzelm E; Knighton DR; Ten Eyck LF; Sowadski JM; Herberg FW; Yonemoto W; Zheng J (1993) Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family. Receptor 3: 165-72.

[2] Knighton DR; Zheng J; Ten Eyck LF; Ashford VA; Xuong N-H; Taylor SS; Sowadski JM (1991 Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase. Science 253: 407-414. [Abstract ] [Science cover image]

[3]Madhusudan; Trafny EA; Xuong NH; Adams JA; Ten Eyck LF; Taylor SS; Sowadski JM (1994) cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci 3: 176-87.

[4] Knighton DR; Zheng JH; Ten Eyck LF; Xuong N-H; Taylor SS; Sowadski JM (1991) Science 253: 414-20.[Abstract]

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Sequence Information

Last modified Wednesday, 30 July 1997 by Phil Bourne