1ATP

cAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37)

Catalytic Subunit Complex with the Peptide Inhibitor PKI(5-24) and MnATP :
A Ternary Complex of cAPK



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Synopsis

Protein kinase catalytic domain with the 20 peptide inhibitor shown in yellow. The ATP is shown in dark yellow and the two manganese ions in green. Phosphates are in purple.

References

[1] Taylor SS; Radzio-Andzelm E; Knighton DR; Ten Eyck LF; Sowadski JM; Herberg FW; Yonemoto W; Zheng J (1993) Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family. Receptor 3: 165-72.

[2] Knighton DR; Zheng J; Ten Eyck LF; Ashford VA; Xuong N-H; Taylor SS; Sowadski JM (1991 Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase. Science 253: 407-414. [Abstract ] [Science cover image]

[3]Madhusudan; Trafny EA; Xuong NH; Adams JA; Ten Eyck LF; Taylor SS; Sowadski JM (1994) cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci 3: 176-87.

[4] Knighton DR; Zheng JH; Ten Eyck LF; Xuong N-H; Taylor SS; Sowadski JM (1991) Science 253: 414-20.[Abstract]

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Sequence Information