Snapshot - 1CDK

MOL_ID: 1; MOLECULE: CAMP-DEPENDENT PROTEIN KINASE; CHAIN: A, B; DOMAIN: CATALYTIC SUBUNIT; SYNONYM: PROTEIN KINASE A; EC: 2.7.1.37; MOL_ID: 2; MOLECULE: PROTEIN KINASE INHIBITOR; CHAIN: I, J; DOMAIN: PEPTIDE FRAGMENT 5 - 24 (ISOELECTRIC VARIANT CA); SYNONYM: PKI(5-24); ENGINEERED: YES; HETEROGEN: MN==2+== ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP)

Compound summary followed by details of each entity.

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      Resolution: 2.00 Å                        Deposition Date: 04-JUL-94

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: SUS SCROFA; 
              ORGANISM_COMMON: PIG; TISSUE: HEART ISOFORM CA; 
              MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: 
              ORYCTOLAGUS CUNICULUS; ORGANISM_COMMON: RABBIT 
              
      Functional Class: COMPLEX (TRANSFERASE/INHIBITOR)         

      Authors: D.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER 
               
      Primary Citation: D.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER 
                        PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM 
                        OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC 
                        SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 
                        ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== 
                        ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE 
                        PKI(5-24) EMBO J. V. 12 849 1993 ASTM EMJODG UK 
                        ISSN 0261-4189 0897 
                        
      Number of Entities: 6

Entity 1CDKA

      Type: Protein                  Molecular Weight: 46773
      Number of Residues: 350
      Number of Alpha: 11            Content of Alpha: 35
      Number of Beta: 10             Content of Beta: 11

      Secondary structure by segment:

     LHLELELELEHLHLELELHLHLELELELELHLHLHLHLHLHL

      Sequence and secondary structure:

   1 GNAAAAKKGS EQESVKEFLA KAKEDFLKKW ENPAQNTAHL DQFERIKTLG 
            TTH HHHHHHHHHH HHHHHHHHHH HT      TG GGEEE  B E 

  51 TGSFGRVMLV KHKETGNHFA MKILDKQKVV KLKQIEHTLN EKRILQAVNF 
     E SS EEEEE EETTTT EEE EEEEEHHHHH HTTTHHHHHH HHHHHHHT T 

 101 PFLVKLEYSF KDNSNLYMVM EYVPGGEMFS HLRRIGRFSE PHARFYAAQI 
     TTB  B EEE E SSEEEEEE   TTTTBHHH HHHHHTS TH HHHHHHHHHH 

 151 VLTFEYLHSL DLIYRDLKPE NLLIDQQGYI QVTDFGFAKR VKGRTWTLCG 
     HHHHHHHHHT TEE    TGG GEEETTTT E EE  TTTTEE  SS B    S 

 201 TPEYLAPEII LSKGYNKAVD WWALGVLIYE MAAGYPPFFA DQPIQIYEKI 
     THHHHHHHHH TTT BTGHHH HHHHHHHHHH HHHTS SS   STHHHHHHHH 

 251 VSGKVRFPSH FSSDLKDLLR NLLQVDLTKR FGNLKDGVND IKNHKWFATT 
     HHT    TTT TTHHHHHHHH HHT STGGGG GGGGGGGGHH HHHGGGGGGG 

 301 DWIAIYQRKV EAPFIPKFKG PGDTSNFDDY EEEEIRVSIN EKCGKEFSEF 
     GHHHHHGTTS   S     ST GGGGGGT            SS   TTGGGGGT 



Entity 1CDK2

      Type: None                     Molecular Weight: 0
      Number of Residues: 2
      Number of Alpha: 0             Content of Alpha: 0
      Number of Beta: 0              Content of Beta: 0

      Secondary structure by segment:

     L

      Sequence and secondary structure:

   1 ** 
        



Entity 1CDKI

      Type: Protein                  Molecular Weight: 2564
      Number of Residues: 20
      Number of Alpha: 1             Content of Alpha: 35
      Number of Beta: 0              Content of Beta: 0

      Secondary structure by segment:

     LHL

      Sequence and secondary structure:

   1 TTYADFIASG RTGRRNAIHD 
     THHHHHHHTS   S        



Entity 1CDKB

      Type: Protein                  Molecular Weight: 46773
      Number of Residues: 350
      Number of Alpha: 11            Content of Alpha: 35
      Number of Beta: 11             Content of Beta: 12

      Secondary structure by segment:

     LHLELELELELEHLHLELELHLHLELELELELHLHLHLHLHLHL

      Sequence and secondary structure:

   1 GNAAAAKKGS EQESVKEFLA KAKEDFLKKW ENPAQNTAHL DQFERIKTLG 
            THH HHHHHHHHHH HHHHHHHHHH HT      TG GGEEE EE E 

  51 TGSFGRVMLV KHKETGNHFA MKILDKQKVV KLKQIEHTLN EKRILQAVNF 
     E SS EEEEE EETTTT EEE EEEEEHHHHH HTTTHHHHHH HHHHHHHT T 

 101 PFLVKLEYSF KDNSNLYMVM EYVPGGEMFS HLRRIGRFSE PHARFYAAQI 
     TTB  B EEE E SSEEEEEE   TTTTBHHH HHHHHTS TH HHHHHHHHHH 

 151 VLTFEYLHSL DLIYRDLKPE NLLIDQQGYI QVTDFGFAKR VKGRTWTLCG 
     HHHHHHHHHG TEE    TGG GEEETTTT E EE  TTTTEE  SS B    S 

 201 TPEYLAPEII LSKGYNKAVD WWALGVLIYE MAAGYPPFFA DQPIQIYEKI 
     THHHHHHHHH TTT BTGHHH HHHHHHHHHH HHHTS SS   STHHHHHHHH 

 251 VSGKVRFPSH FSSDLKDLLR NLLQVDLTKR FGNLKDGVND IKNHKWFATT 
     HHT    TTT TTHHHHHHHH HHT STGGGG GGTSSTGGHH HHGGGGGGGT 

 301 DWIAIYQRKV EAPFIPKFKG PGDTSNFDDY EEEEIRVSIN EKCGKEFSEF 
     THHHHHTTTS   S     ST GGGGGGT            SS  STTTGGGGT 



Entity 1CDK5

      Type: None                     Molecular Weight: 0
      Number of Residues: 2
      Number of Alpha: 0             Content of Alpha: 0
      Number of Beta: 0              Content of Beta: 0

      Secondary structure by segment:

     L

      Sequence and secondary structure:

   1 ** 
        



Entity 1CDKJ

      Type: Protein                  Molecular Weight: 2564
      Number of Residues: 20
      Number of Alpha: 1             Content of Alpha: 35
      Number of Beta: 0              Content of Beta: 0

      Secondary structure by segment:

     LHL

      Sequence and secondary structure:

   1 TTYADFIASG RTGRRNAIHD 
     THHHHHHHTS   S