1CMK

cAMP-dependent PROTEIN KINASE (E.C.2.7.1.37)
Catalytic Domain


3-DHome | Crystallography | Snapshot | Render | References | Walk Through | Sequence Info

Synopsis

Standard Protein Kinase catalytic core in an open conformation. The PKI inhibitor is shown in yellow. The structure is iodinated and the two iodines are shown as grey spheres. Two phosphates are shown in green.

References

[1] Zheng J; Knighton DR; Xuong NH; Taylor SS; Sowadski JM; Ten Eyck LF (1993) Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci 2: 1559-73. [Abstract]

[2] Zheng J; Knighton DR; Ten Eyck LF; Karlsson R; Xuong N; Taylor SS; Sowadski JM. (1993) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 32: 2154-61. [Abstract]

[3] Karlsson R; Zheng J; Xuong N-H; Taylor SS; Sowadski JM (1993) The crystal structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and a di-iodinated PKI(5-24) inhibitor peptide displays an open conformation. Acta Crystallogr, Sect D 49: 381.

Walk Through

Sequence Information