1ERK

MAP KINASE (ERK2) Complexed with MgATP (CATALYTIC SUBUNIT)



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Synopsis

The crystal structure or ERK2 and a MgATP complex reveal the complex conformational restraints that appear to supress kinase activity in the unphosphorylated enzyme.

References

[1] Zhang J; Zhang F; Ebert D; Cobb MH; Goldsmith EJ Structure 3: 299-307 (1995) Activity of the MAP kinase ERK2 is controlled by a flexible surface loop.[
Abstract]

[2] Zhang F; Strand A; Robbins D; Cobb MH; Goldsmith EJ Nature 367: 704-11 (1994) Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. [Abstract]

[3] Cobb MH; Goldsmith EJ J Biol Chem 270: 14843-6 (1995) How MAP kinases are regulated.

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Sequence Information


Last modified Thursday, 23 October 1997 by Christopher Smith