Snapshot - 1FGK

MOL_ID: 1; MOLECULE: FGF RECEPTOR 1; CHAIN: A, B; FRAGMENT: TYROSINE KINASE DOMAIN, HUMAN FGFR1 RESIDUES THAT POSSESS PTK ACTIVITY; SYNONYM: FGFR1K, FIBROBLAST GROWTH FACTOR RECEPTOR 1; EC: 2.7.1.112; ENGINEERED: YES; MUTATION: L457V, C488A, C584S

Compound summary followed by details of each entity.

Query Types: Text | Entity | Pattern | Load User List
Home | Contents | How it Works | Roadmap | Comments Please | Other Resources | Help


To review all results of the last query or to use them as an input for the next query click here


      Resolution: 2.00 Å                        Deposition Date: 08-FEB-97

      Source: MOL_ID: 1; FRAGMENT: HUMAN FGFR1 RESIDUES 456-765 
              THAT POSSESSES PTK ACTIVITY; ORGANISM_SCIENTIFIC: 
              HOMO SAPIENS; ORGANISM_COMMON: HUMAN; 
              CELLULAR_LOCATION: CYTOPLASM; EXPRESSION_SYSTEM: 
              BACULOVIRUS/INSECT CELL 
              
      Functional Class: PHOSPHOTRANSFERASE                      

      Authors: M.MOHAMMADI,J.SCHLESSINGER,S.R.HUBBARD 
               
      Primary Citation: 
      Number of Entities: 2

Entity 1FGK:A

      Type: Protein                  Molecular Weight: 40827
      Number of Residues: 310
      Number of Alpha: 8             Content of Alpha: 31.61
      Number of Beta: 7              Content of Beta: 9.68

      Secondary structure by segment:

     LELELELHLELELHLHLELELHLHLHLHLHL

      Sequence and secondary structure:

   1 MVAGVSEYEL PEDPRWELPR DRLVLGKPLG EGAFGQVVLA EAIGLDKDKP 
                  TTTTB TG GGEEE  B B       EEEE EEE        

  51 NRVTKVAVKM LKSDATEKDL SDLISEMEMM KMIGKHKNII NLLGACTQDG 
       EEEEEEE   TTTTTHHHH HHHHHHHHHH HHHT TTTB   B EEE SSS 

 101 PLYVIVEYAS KGNLREYLQA RRPPGLEYSY NPSHNPEEQL SSKDLVSCAY 
     S EEEE  TT TTBHHHHHHG GT                    THHHHHHHHH 

 151 QVARGMEYLA SKKCIHRDLA ARNVLVTEDN VMKIADFGLA RDIHHIDYYK 
     HHHHHHHHHH HTTT  S  T GGGEEETTTT  EEE TTTT   TGGGGGGGT 

 201 KTTNGRLPVK WMAPEALFDR IYTHQSDVWS FGVLLWEIFT LGGSPYPGVP 
     BTTTT BGGG GTTHHHHHHT   THHHHHHH HHHHHHHHHT TT TGGGGGG 

 251 VEELFKLLKE GHRMDKPSNC TNELYMMMRD CWHAVPSQRP TFKQLVEDLD 
     HHHHHHHHHT TT     SS  THHHHHHHHH HTTSTGGGT  THHHHHHHHH 

 301 RIVALTSNQE 
     HHHHHT     



Entity 1FGK:B

      Type: Protein                  Molecular Weight: 40827
      Number of Residues: 310
      Number of Alpha: 8             Content of Alpha: 32.58
      Number of Beta: 8              Content of Beta: 11.94

      Secondary structure by segment:

     LELELELELHLELELHLHLELELHLHLHLHLHL

      Sequence and secondary structure:

   1 MVAGVSEYEL PEDPRWELPR DRLVLGKPLG EGAFGQVVLA EAIGLDKDKP 
            S     TTTTB TG GGEEE SB E E SSEEEEEE EEE        

  51 NRVTKVAVKM LKSDATEKDL SDLISEMEMM KMIGKHKNII NLLGACTQDG 
       EEEEEEEE ETTTTTHHHH HHHHHHHHHH HHHT TTTB   B EEE SSS 

 101 PLYVIVEYAS KGNLREYLQA RRPPGLEYSY NPSHNPEEQL SSKDLVSCAY 
     S EEEEE TT TTBHHHHHHG GT                    THHHHHHHHH 

 151 QVARGMEYLA SKKCIHRDLA ARNVLVTEDN VMKIADFGLA RDIHHIDYYK 
     HHHHHHHHHH HTTT  S  T GGGEEETTTT  EEE TTTT        TTTT 

 201 KTTNGRLPVK WMAPEALFDR IYTHQSDVWS FGVLLWEIFT LGGSPYPGVP 
           TGHH HHHHHHHHT    THHHHHHH HHHHHHHHHT TT TGGGGTT 

 251 VEELFKLLKE GHRMDKPSNC TNELYMMMRD CWHAVPSQRP TFKQLVEDLD 
     HHHHHHHHHT TT     SS  THHHHHHHHH HTTSTGGGT  THHHHHHHHH 

 301 RIVALTSNQE 
     HHHHTT