Snapshot - 1HCK

MOL_ID: 1; MOLECULE: HUMAN CYCLIN-DEPENDENT KINASE 2; CHAIN: NULL; SYNONYM: CDK2; EC: 2.7.1.37; ENGINEERED: YES

Compound summary followed by details of each entity.

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      Resolution: 1.90 Å                        Deposition Date: 03-JUN-96

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; 
              ORGANISM_COMMON: HUMAN; EXPRESSION_SYSTEM: SF9 
              CELLS; EXPRESSION_SYSTEM_PLASMID: BACULOVIRUS 
              
      Functional Class: PROTEIN KINASE                          

      Authors: U.SCHULZE-GAHMEN,H.L.DE BONDT,S.-H.KIM 
               
      Primary Citation: U.SCHULZE-GAHMEN,H.L.DE BONDT,S.-H.KIM HIGH 
                        RESOLUTION CRYSTAL STRUCTURE OF HUMAN 
                        CYCLIN-DEPENDENT KINASE 2 WITH AND WITHOUT ATP 
                        BOUND WATERS AND NATURAL LIGAND AS GUIDES FOR 
                        INHIBITOR DESIGN TO BE PUBLISHED 0353 
                        
      Number of Entities: 2

Entity 1HCK:_

      Type: Protein                  Molecular Weight: 39279
      Number of Residues: 298
      Number of Alpha: 10            Content of Alpha: 32.89
      Number of Beta: 10             Content of Beta: 14.09

      Secondary structure by segment:

     LELELELELELHLELELEHLHLELELHLHLHLHLHLHLHL

      Sequence and secondary structure:

   1 MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR 
     TTTEEE EE  EE SSEEEEE EEETTTT EE EEEEE        S THHHHH 

  51 EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP 
     HHHHHGGT T TTB  B EEE EETTEEEEEE E  SEEHHHH HHHHHHHT T 

 101 LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINTEGA IKLADFGLAR 
     HHHHHHHHHH HHHHHHHHHH GTT     TG GGEEETTTT  EEE THHHHH 

 151 AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMVTRR 
     HHTT SBTTT T B  TGGGG HHHHGTTSS  TGHHHHHHHH HHHHHHHHTT 

 201 ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK 
      S   STHHH HHHHHHHHHT   TTTTTGGG GGGGGGGGGT       THHH 

 251 VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL 
     HTTTTTHHHH HHHHHHTTST TTTT THHHH GGGGGGGGT           



Entity 1HCK:_:1

      Type: None                     Molecular Weight: 0
      Number of Residues: 2
      Number of Alpha: 0             Content of Alpha: 0.00
      Number of Beta: 0              Content of Beta: 0.00

      Secondary structure by segment:

     L

      Sequence and secondary structure:

   1 **