Complexed with ATP

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Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.


[1] Schulze-Gahmen U;Brandsen J; Jones HD; Morgan DO; Meijer L; Vesely J; Kim SH. (1995) Multiple modes of ligand recognition: crystal structures of cyclin-depenent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine. Proteins 22: 378-391. [

[2]De Bondt HL; Rosenblatt J; Jancarik J; Jones HD; Morgan DO; Kim SH (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363: 595-602. [Abstract]

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Sequence Information