CYCLIN-DEPENDENT PROTEIN KINASE 2
Complexed with ATP
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that
regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP
complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic
AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and
protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.
 Schulze-Gahmen U;Brandsen J; Jones HD; Morgan DO; Meijer L; Vesely J; Kim SH. (1995) Multiple modes of ligand recognition:
crystal structures of cyclin-depenent protein kinase 2 in complex with ATP
and two inhibitors, olomoucine and isopentenyladenine. Proteins
22: 378-391. [Abstract]
De Bondt HL; Rosenblatt J; Jancarik J; Jones HD; Morgan DO; Kim SH (1993)
Crystal structure of cyclin-dependent kinase 2. Nature 363:
A walkthrough based on the subdomain scheme of Hanks and Hunter.