Snapshot - 1IR3

MOL_ID: 1; MOLECULE: INSULIN RECEPTOR; CHAIN: A; FRAGMENT: TYROSINE KINASE DOMAIN; EC: 2.7.1.112; ENGINEERED: YES; MUTATION: C981S, Y984F; BIOLOGICAL_UNIT: TETRAMER OF 2 ALPHA AND 2 BETA CHAINS LINKED BY DISULFIDE BONDS; MOL_ID: 2; MOLECULE: PEPTIDE SUBSTRATE; CHAIN: B; ENGINEERED: YES

Compound summary followed by details of each entity.

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      Resolution: 1.90 Å                        Deposition Date: 22-SEP-97

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; 
              ORGANISM_COMMON: HUMAN; EXPRESSION_SYSTEM: 
              SPODOPTERA FRUGIPERDA INSECT CELLS; 
              EXPRESSION_SYSTEM_STRAIN: SF9; 
              EXPRESSION_SYSTEM_CELLULAR_LOCATION: CYTOPLASM; 
              EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; 
              MOL_ID: 2; SYNTHETIC: DERIVED FROM PHOSPHORYLATION 
              SITE TYR 727 ON RAT IRS-1 
              
      Functional Class: COMPLEX (TRANSFERASE/SUBSTRATE)         

      Authors: S.R.HUBBARD 
               
      Primary Citation: S.R.HUBBARD CRYSTAL STRUCTURE OF THE ACTIVATED 
                        INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH 
                        PEPTIDE SUBSTRATE AND ATP ANALOG EMBO J. V. 16 
                        5572 1997 ASTM EMJODG UK ISSN 0261-4189 0897 
                        
      Number of Entities: 3

Entity 1IR3:A

      Type: Protein                  Molecular Weight: 39702
      Number of Residues: 306
      Number of Alpha: 9             Content of Alpha: 32.68
      Number of Beta: 13             Content of Beta: 15.36

      Secondary structure by segment:

     LELELELELELHLELELHLHLELELELELELHLELHLHLHLHLHL

      Sequence and secondary structure:

   1 VFPSSVFVPD EWEVSREKIT LLRELGQGSF GMVYEGNARD IIKGEAETRV 
        TGGGT T TTB TGGGEE E EE EE SS EEEEEEEEES  BTTBSEEEE 

  51 AVKTVNESAS LRERIEFLNE ASVMKGFTCH HVVRLLGVVS KGQPTLVVME 
     EEEEETTTTT HHHHHHHHHH HHHHHGT TT TB  B EEE  SSSS EEEEE 

 101 LMAHGDLKSY LRSLRPEAEN NPGRPPPTLQ EMIQMAAEIA DGMAYLNAKK 
      TTTTBHHHH HHHGGGGGGG T SS S THH HHHHHHHHHH HHHHHHHHTT 

 151 FVHRDLAARN CMVAHDFTVK IGDFGMTRDI *ETD**RKGG KGLLPVRWMA 
     EE S  TGGG EEETTTT EE E  TTTTEET TTTT EE  S     THHHHH 

 201 PESLKDGVFT TSSDMWSFGV VLWEITSLAE QPYQGLSNEQ VLKFVMDGGY 
     HHHHHHTEET HHHHHHHHHH HHHHHHTTT  TGGGGTTHHH HHHHHHTTT  

 251 LDQPDNCPER VTDLMRMCWQ FNPKMRPTFL EIVNLLKDDL HPSFPEVSFF 
        TGGGGHH HHHHHHHHTT STGGGT THH HHHHHHGGGG GGGHHHHTTG 

 301 HSEENK 
     GGGGT  



Entity 1IR3:B

      Type: Protein                  Molecular Weight: 2258
      Number of Residues: 18
      Number of Alpha: 0             Content of Alpha: 0.00
      Number of Beta: 0              Content of Beta: 0.00

      Secondary structure by segment:

     L

      Sequence and secondary structure:

   1 KKKLPATGDY MNMSPVGD 
                         



Entity 1IR3:_

      Type: None                     Molecular Weight: 0
      Number of Residues: 2
      Number of Alpha: 0             Content of Alpha: 0.00
      Number of Beta: 0              Content of Beta: 0.00

      Secondary structure by segment:

     L

      Sequence and secondary structure:

   1 **