Snapshot - 1IRK

INSULIN RECEPTOR (TYROSINE KINASE DOMAIN) MUTANT WITH CYS 981 REPLACED BY SER AND TYR 984 REPLACED BY PHE (C981S, Y984F)

Compound summary followed by details of each entity.

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      Resolution: 2.10 Å                        Deposition Date: 02-JAN-95

      Source: HUMAN (HOMO SAPIENS) RECOMBINANT FORM EXPRESSED IN 
              BACULOVIRUS/INSECT CELL 
              
      Functional Class: TRANSFERASE (PHOSPHOTRANSFERASE)        

      Authors: S.R.HUBBARD,L.WEI,L.ELLIS,W.A.HENDRICKSON 
               
      Primary Citation: S.R.HUBBARD,L.WEI,L.ELLIS,W.A.HENDRICKSON CRYSTAL 
                        STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE 
                        HUMAN INSULIN RECEPTOR NATURE V. 372 746 1994 ASTM 
                        NATUAS UK ISSN 0028-0836 0006 
                        
      Number of Entities: 1

Entity 1IRK_

      Type: Protein                  Molecular Weight: 40246
      Number of Residues: 306
      Number of Alpha: 9             Content of Alpha: 32
      Number of Beta: 11             Content of Beta: 13

      Secondary structure by segment:

     LELELELELELHLELELHLHLELELELELHLHLHLHLHLHL

      Sequence and secondary structure:

   1 VFPSSVFVPD EWEVSREKIT LLRELGQGSF GMVYEGNARD IIKGEAETRV 
             TG GGB TGGGEE E EE EE SS SEEEEEEEES  TTTTSEEEE 

  51 AVKTVNESAS LRERIEFLNE ASVMKGFTCH HVVRLLGVVS KGQPTLVVME 
     EEE  TTTTT HHHHHHHHHH HHHHGGT TT TB  B EEE  SSSS EEEEE 

 101 LMAHGDLKSY LRSLRPEAEN NPGRPPPTLQ EMIQMAAEIA DGMAYLNAKK 
      TTTTBHHHH HHHGGGGGGG T S  S THH HHHHHHHHHH HHHHHHHHTT 

 151 FVHRDLAARN CMVAHDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMA 
     T  S  TGGG EEETTTT EE E   S SSTG GGGGTEEGGG TSEETHHHHH 

 201 PESLKDGVFT TSSDMWSFGV VLWEITSLAE QPYQGLSNEQ VLKFVMDGGY 
     HHHHHHT  T HHHHHHHHHH HHHHHHTTT  TGGGGTTHHH HHHHHHTTT  

 251 LDQPDNCPER VTDLMRMCWQ FNPKMRPTFL EIVNLLKDDL HPSFPEVSFF 
         SS THH HHHHHHHHTT STGGGT THH HHHHHHGGGG GGGHHHHTTG 

 301 HSEENK 
     GGGGT