Snapshot - 1STC

MOL_ID: 1; MOLECULE: CAMP-DEPENDENT PROTEIN KINASE; CHAIN: E; FRAGMENT: CATALYTIC SUBUNIT; SYNONYM: CAPK, PROTEIN KINASE A, PKA C-ALPHA; EC: 2.7.1.37; ENGINEERED: YES; MOL_ID: 2; MOLECULE: PROTEIN KINASE INHIBITOR; CHAIN: I; FRAGMENT: INHIBITORY DOMAIN; SYNONYM: PKI, PKI-ALPHA; ENGINEERED: YES

Compound summary followed by details of each entity.

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      Resolution: 2.30 Å                        Deposition Date: 10-OCT-97

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; 
              ORGANISM_COMMON: BOVINE; EXPRESSION_SYSTEM: 
              ESCHERICHIA COLI; EXPRESSION_SYSTEM_STRAIN: BL21 
              (DE3) PLYS; EXPRESSION_SYSTEM_PLASMID: PT7-7; 
              MOL_ID: 2; SYNTHETIC: YES 
              
      Functional Class: COMPLEX (TRANSFERASE/INHIBITOR)         

      Authors: L.PRADE,R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER,D.BOSSEME
               YER 
               
      Primary Citation: L.PRADE,R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER, 
                        D.BOSSEMEYER STAUROSPORINE INDUCED CONFORMATIONAL 
                        CHANGES OF PROTEIN KINASE A CATALYTIC SUBUNIT 
                        EXPLAIN INHIBITORY POTENTIAL STRUCTURE (LONDON) V. 
                        5 1627 1997 ASTM STRUE6 UK ISSN 0969-2126 2005 
                        
      Number of Entities: 2

Entity 1STC:E

      Type: Protein                  Molecular Weight: 46446
      Number of Residues: 350
      Number of Alpha: 13            Content of Alpha: 36.86
      Number of Beta: 11             Content of Beta: 12.29

      Secondary structure by segment:

     LHLELELELELEHLHLELELHLHLELELELELHLHLHLHLHLHLHLHL

      Sequence and secondary structure:

   1 GNAAAAKKG* EQESVKEFLA KAKEDFLKKW ENPAQNTAHL DQFERIKTLG 
                    THHHHH HHHHHHHHHH HT      TG GGEEE EE E 

  51 TGSFGRVMLV KHMETGNHYA MKILDKQKVV KLKQIEHTLN EKRILQAVNF 
     ESSSEEEEEE EETTTT EEE EEEEEHHHHH HTTTHHHHHH HHHHHHHT T 

 101 PFLVKLEFSF KDNSNLYMVM EYVPGGEMFS HLRRIGRFSE PHARFYAAQI 
     TTB  B EEE E SSEEEEEE E TTTTBHHH HHHHHTS TH HHHHHHHHHH 

 151 VLTFEYLHSL DLIYRDLKPE NLLIDQQGYI QVTDFGFAKR VKGRTW*LCG 
     HHHHHHHHHG TEE    TGG GTEETTTT E EE  TTTTEE  SS B    S 

 201 TPEYLAPEII LSKGYNKAVD WWALGVLIYE MAAGYPPFFA DQPIQIYEKI 
     THHHHHHHHH TTT BTGHHH HHHHHHHHHH HHHTS SS   STHHHHHHHH 

 251 VSGKVRFPSH FSSDLKDLLR NLLQVDLTKR FGNLKNGVND IKNHKWFATT 
     HHTT   TTT TTHHHHHHHH HHT STHHHH HHHTSTGGHH HHGGGGGGGT 

 301 DWIAIYQRKV EAPFIPKFKG PGDTSNFDDY EEEEIRV*IN EKCGKEFSEF 
     THHHHHHTTS   SS    ST TTT SSS            SS   THHHHGGT 



Entity 1STC:I

      Type: Protein                  Molecular Weight: 2564
      Number of Residues: 20
      Number of Alpha: 1             Content of Alpha: 40.00
      Number of Beta: 0              Content of Beta: 0.00

      Secondary structure by segment:

     LHL

      Sequence and secondary structure:

   1 TTYADFIASG RTGRRNAIHD 
     THHHHHHHHT T S