Snapshot - 1YDR

MOL_ID: 1; MOLECULE: C-AMP-DEPENDENT PROTEIN KINASE; CHAIN: E; FRAGMENT: CATALYTIC SUBUNIT; SYNONYM: CAPK, PKA C-ALPHA; EC: 2.7.1.37; ENGINEERED: YES; OTHER_DETAILS: ALPHA ISOENZYME; MOL_ID: 2; MOLECULE: PROTEIN KINASE INHIBITOR PEPTIDE; CHAIN: I; SYNONYM: PKI, PKI-ALPHA; ENGINEERED: YES

Compound summary followed by details of each entity.

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      Resolution: 2.20 Å                        Deposition Date: 24-JUL-96

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; 
              ORGANISM_COMMON: BOVINE; EXPRESSION_SYSTEM: 
              ESCHERICHIA COLI; MOL_ID: 2; SYNTHETIC: YES 
              
      Functional Class: COMPLEX (PHOSPHOTRANSFERASE/INHIBITOR)  

      Authors: R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER,D.BOSSEMEYER 
               
      Primary Citation: R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER,D.BOSSEMEYER 
                        CRYSTAL STRUCTURES OF CATALYTIC SUBUNIT OF 
                        CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH 
                        ISOQUINOLINESULFONYL PROTEIN KINASE INHIBITORS H7, 
                        H8, AND H89. STRUCTURAL IMPLICATIONS FOR 
                        SELECTIVITY J.BIOL.CHEM. V. 271 26157 1996 ASTM 
                        JBCHA3 US ISSN 0021-9258 0071 
                        
      Number of Entities: 2

Entity 1YDR:E

      Type: Protein                  Molecular Weight: 46526
      Number of Residues: 350
      Number of Alpha: 11            Content of Alpha: 33.43
      Number of Beta: 10             Content of Beta: 11.71

      Secondary structure by segment:

     LHLELELELEHLHLELELHLHLELELELELHLHLHLHLHLHL

      Sequence and secondary structure:

   1 GNAAAAKKGS EQESVKEFLA KAKEDFLKKW ENPAQNTAHL DQFERIKTLG 
                    THHHHH HHHHHHHHHH HTT     TG GGEEE EE B 

  51 TGSFGRVMLV KHMETGNHYA MKILDKQKVV KLKQIEHTLN EKRILQAVNF 
       SS  EEEE EETTTTEEEE EEEEEHHHHH HTTTHHHHHH HHHHHHHT T 

 101 PFLVKLEFSF KDNSNLYMVM EYVAGGEMFS HLRRIGRFSE PHARFYAAQI 
     TTB  B EEE E SSEEEEEE E TTTTBHHH HHHHHT  TH HHHHHHHHHH 

 151 VLTFEYLHSL DLIYRDLKPE NLLIDQQGYI QVTDFGFAKR VKGRTW*LCG 
     HHHHHHHHHG TEE    TGG GEEETTTT E EE  TTTTEE  SS B    S 

 201 TPEYLAPEII LSKGYNKAVD WWALGVLIYE MAAGYPPFFA DQPIQIYEKI 
     THHHHHHHHH GTT BTGHHH HHHHHHHHHH HHHTS SS   STHHHHHHHH 

 251 VSGKVRFPSH FSSDLKDLLR NLLQVDLTKR FGNLKDGVND IKNHKWFATT 
     HHTT   TTT TTHHHHHHHH HHTTSTGGGG GGGGGGGGHH HHGGGGGTS  

 301 DWIAIYQRKV EAPFIPKFKG PGDTSNFDDY EEEEIRV*IN EKCGKEFSEF 
     THHHHHTTTS   S     ST GGGGGGT            SS   TTTGGGGT 



Entity 1YDR:I

      Type: Protein                  Molecular Weight: 2564
      Number of Residues: 20
      Number of Alpha: 1             Content of Alpha: 30.00
      Number of Beta: 0              Content of Beta: 0.00

      Secondary structure by segment:

     LHL

      Sequence and secondary structure:

   1 TTYADFIASG RTGRRNAIHD 
     THHHHHHTTS  SS