Snapshot - 1YDS

MOL_ID: 1; MOLECULE: C-AMP-DEPENDENT PROTEIN KINASE; CHAIN: E; FRAGMENT: CATALYTIC SUBUNIT; SYNONYM: CAPK, PKA C-ALPHA; EC: 2.7.1.37; ENGINEERED: YES; OTHER_DETAILS: ALPHA ISOENZYME; MOL_ID: 2; MOLECULE: PROTEIN KINASE INHIBITOR PEPTIDE; CHAIN: I; SYNONYM: PKI, PKI-ALPHA; ENGINEERED: YES

Compound summary followed by details of each entity.

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      Resolution: 2.20 Å                        Deposition Date: 24-JUL-96

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; 
              ORGANISM_COMMON: BOVINE; EXPRESSION_SYSTEM: 
              ESCHERICHIA COLI; MOL_ID: 2; SYNTHETIC: YES 
              
      Functional Class: COMPLEX (PHOSPHOTRANSFERASE/INHIBITOR)  

      Authors: R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER,D.BOSSEMEYER 
               
      Primary Citation: R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER,D.BOSSEMEYER 
                        CRYSTAL STRUCTURES OF CATALYTIC SUBUNIT OF 
                        CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH 
                        ISOQUINOLINESULFONYL PROTEIN KINASE INHIBITORS H7, 
                        H8, AND H89. STRUCTURAL IMPLICATIONS FOR 
                        SELECTIVITY J.BIOL.CHEM. V. 271 26157 1996 ASTM 
                        JBCHA3 US ISSN 0021-9258 0071 
                        
      Number of Entities: 2

Entity 1YDS:E

      Type: Protein                  Molecular Weight: 46526
      Number of Residues: 350
      Number of Alpha: 11            Content of Alpha: 33.43
      Number of Beta: 11             Content of Beta: 12.86

      Secondary structure by segment:

     LHLELELELELEHLHLELELHLHLELELELELHLHLHLHLHLHL

      Sequence and secondary structure:

   1 GNAAAAKKGS EQESVKEFLA KAKEDFLKKW ENPAQNTAHL DQFERIKTLG 
                    THHHHH HHHHHHHHHH HT      TG GGEEE EE E 

  51 TGSFGRVMLV KHMETGNHYA MKILDKQKVV KLKQIEHTLN EKRILQAVNF 
     E SSEEEEEE EETTTTEEEE EEEEEHHHHH HTTTHHHHHH HHHHHHHT T 

 101 PFLVKLEFSF KDNSNLYMVM EYVAGGEMFS HLRRIGRFSE PHARFYAAQI 
     TTB  B EEE E SSEEEEEE E TTTTBHHH HHHHHT  TH HHHHHHHHHH 

 151 VLTFEYLHSL DLIYRDLKPE NLLIDQQGYI QVTDFGFAKR VKGRTW*LCG 
     HHHHHHHHHG TEE    TGG GEEETTTT E EE  TTTTEE  SS B    S 

 201 TPEYLAPEII LSKGYNKAVD WWALGVLIYE MAAGYPPFFA DQPIQIYEKI 
     THHHHHHHHH TTT BTGHHH HHHHHHHHHH HHHTS SS   STHHHHHHHH 

 251 VSGKVRFPSH FSSDLKDLLR NLLQVDLTKR FGNLKDGVND IKNHKWFATT 
     HHTT   TTT TTHHHHHHHH HHT STGGGG GGGGGGGGHH HHGGGGGGGT 

 301 DWIAIYQRKV EAPFIPKFKG PGDTSNFDDY EEEEIRV*IN EKCGKEFSEF 
     THHHHHTTTS   S     ST GGGGGGT            SS   TTTGGGGT 



Entity 1YDS:I

      Type: Protein                  Molecular Weight: 2564
      Number of Residues: 20
      Number of Alpha: 1             Content of Alpha: 30.00
      Number of Beta: 0              Content of Beta: 0.00

      Secondary structure by segment:

     LHL

      Sequence and secondary structure:

   1 TTYADFIASG RTGRRNAIHD 
     THHHHHHTTS  SS