2CPK

cAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37)

Catalytic Subunit (Alpha Isozyme)



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Synopsis

Secondary structure representation of the C-subunit of protein kinase with essential conserved residues shown in white. The primary phospohorylation site Thr 197 is indicated by the arrow.

References

[1] Taylor SS; Radzio-Andzelm E; Knighton DR; Ten Eyck LF; Sowadski JM; Herberg FW; Yonemoto W; Zheng J (1993) Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family. Receptor 3: 165-72.

[2] Knighton DR; Zheng J; Ten Eyck LF;, Ashford VA; Xuong N-H; Taylor SS; Sowadski JM (1991) Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase. Science , 253: 407-414. [Abstract] [Sciencecover photo]

[3] Madhusudan; Trafny EA; Xuong NH; Adams JA; Ten Eyck LF; Taylor SS; Sowadski JM (1994) cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci 3: 176-87.

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Sequence Information