Snapshot - 2CSN

MOL_ID: 1; MOLECULE: CASEIN KINASE-1; CHAIN: NULL; FRAGMENT: CATALYTIC CORE RESIDUES 2 - 298; EC: 2.7.1.-; ENGINEERED: YES; HETEROGEN: CKI7=N-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE

Compound summary followed by details of each entity.

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      Resolution: 2.50 Å                        Deposition Date: 11-OCT-95

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: 
              SCHIZOSACCHAROMYCES POMBE; ORGANISM_COMMON: 
              FISSION YEAST; EXPRESSION_SYSTEM: ESCHERICHIA COLI 
              
      Functional Class: PROTEIN KINASE                          

      Authors: R.-M.XU,X.CHENG 
               
      Primary Citation: R.-M.XU,G.CARMEL,J.KURET,X.CHENG STRUCTURAL BASIS 
                        FOR SELECTIVITY OF THE ISOQUINOLINE SULFONAMIDE 
                        FAMILY OF PROTEIN KINASES INHIBITORS TO BE 
                        PUBLISHED 0353 
                        
      Number of Entities: 1

Entity 2CSN:_

      Type: Protein                  Molecular Weight: 39530
      Number of Residues: 297
      Number of Alpha: 8             Content of Alpha: 36.70
      Number of Beta: 11             Content of Beta: 15.49

      Secondary structure by segment:

     LELELELELELHLELELHLHLELELELELHLHLHLHLHL

      Sequence and secondary structure:

   1 SGQNNVVGVH YKVGRRIGEG SFGVIFEGTN LLNNQQVAIK FEPRRSDAPQ 
          EETTT EEE  B EEE TTEEEEEEEE TTTT EEEEE EEE TTTT T 

  51 LRDEYRTYKL LAGCTGIPNV YYFGQEGLHN VLVIDLLGPS LEDLLDLCGR 
     HHHHHHHHHH HGGGGGB  B  EEEEETTEE EEEEE    B HHHHHHHTTT 

 101 KFSVKTVAMA AKQMLARVQS IHEKSLVYRD IKPDNFLIGR PNSKNANMIY 
       THHHHHHH HHHHHHHHHH HHGGTEE     TGGGEEE   SSTGGGGTEE 

 151 VVDFGMVKFY RDPVTKQHIP YREKKNLSGT ARYMSINTHL GREQSRRDDL 
     E  TTTTEES BTTTTT B           ST HHHHHHHHHG TT  THHHHH 

 201 EALGHVFMYF LRGSLPWQGL KAATNKQKYE RIGEKKQSTP LRELCAGFPE 
     HHHHHHHHHH HHTSTTTTS   SSTHHHHHH HHHHHHHHHH HHHHTGGGGH 

 251 EFYKYMHYAR NLAFDATPDY DYLQGLFSKV LERLNTTEDE NFDWNLL 
     HHHHHHHHHH HGGGGT  TH HHHHHHHHHH HHHTTT S S  TGGGT