Snapshot - 2HCK

MOL_ID: 1; MOLECULE: HEMATOPOETIC CELL KINASE HCK; CHAIN: A, B; FRAGMENT: SH3-SH2-KINASE-REGULATORY TAIL; EC: 2.7.1.112; ENGINEERED: YES; BIOLOGICAL_UNIT: MONOMER

Compound summary followed by details of each entity.

Query Types: Text | Entity | Pattern | Load User List
Home | Contents | How it Works | Roadmap | Comments Please | Other Resources | Help


To review all results of the last query or to use them as an input for the next query click here


      Resolution: 3.00 Å                        Deposition Date: 25-FEB-97

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; 
              ORGANISM_COMMON: HUMAN; EXPRESSION_SYSTEM: INSECT 
              CELLS; EXPRESSION_SYSTEM_CELL_LINE: SF9; 
              EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; 
              EXPRESSION_SYSTEM_GENE: HUMAN HCK 
              
      Functional Class: TRANSFERASE                             

      Authors: F.SICHERI,I.MOAREFI,J.KURIYAN 
               
      Primary Citation: F.SICHERI,I.MOAREFI,J.KURIYAN CRYSTAL STRUCTURE OF 
                        THE SRC FAMILY TYROSINE KINASE HCK NATURE V. 385 
                        602 1997 ASTM NATUAS UK ISSN 0028-0836 0006 
                        
      Number of Entities: 2

Entity 2HCK:A

      Type: Protein                  Molecular Weight: 57850
      Number of Residues: 438
      Number of Alpha: 10            Content of Alpha: 25.11
      Number of Beta: 21             Content of Beta: 20.78

      Secondary structure by segment:

     LELELELELELELELHLELELELELHLELELELELELHLELELEHLHLELELHLHLHLHL
     HL

      Sequence and secondary structure:

   1 EDIIVVALYD YEAIHHEDLS FQKGDQMVVL EESGEWWKAR SLATRKEGYI 
        EEEESS  B   TTTB   BTTTTEEEE  EEETTEEEEE ETTTT EEEE 

  51 PSNYVARVDS LETEEWFFKG ISRKDAERQL LAPGNMLGSF MIRDSETTKG 
     EGGGEEEGGG GGGGGGEEGG TTHHHHHHHH HTGGGGGGTE EEEE SSTTT 

 101 SYSLSVRDYD PRQGDTVKHY KIRTLDNGGF YISPRSTFST LQELVDHYKK 
     TEEEEEEEE  SSSSEEEEEE EEEE TTTTE ESTTTT BST HHHHHHHHHH 

 151 GNDGLCQKLS VPCMSSKPQK PWEKDAWEIP RESLKLEKKL GAGQFGEVWM 
     T  SSSS     B           TGGGGB T GGGEEE EE  EE SSEEEEE 

 201 ATYNKHTKVA VKTMKPGSMS VEAFLAEANV MKTLQHDKLV KLHAVVTKEP 
     EEETTTEEEE EEEETTTTST HHHHHHHHHH HGGT TTTB   B EEE SSS 

 251 IYIITEFMAK GSLLDFLKSD EGSKQPLPKL IDFSAQIAEG MAFIEQRNYI 
     EEEEE  TTT EEHHHHHHHH HHGGGGHHHH HHHHHHHHHH HHHHHHTTT  

 301 HRDLRAANIL VSASLVCKIA DFGLARVGAK FPIKWTAPEA INFGSFTIKS 
      S  TGGGEE ETTTT EEE  S S    SSS STGGGGGHHH HHHT  THHH 

 351 DVWSFGILLM EIVTYGRIPY PGMSNPEVIR ALERGYRMPR PENCPEELYN 
     HHHHHHHHHH HHHGGGT SS SS THHHHHH HHHTTT     TGGGGHHHHH 

 401 IMMRCWKNRP EERPTFEYIQ SVLDDFYTAT ESQ*QQQP 
     HHHHHT STG GGT THHHHH HHHHGGGGGG GGTB     



Entity 2HCK:B

      Type: Protein                  Molecular Weight: 57850
      Number of Residues: 438
      Number of Alpha: 10            Content of Alpha: 25.57
      Number of Beta: 20             Content of Beta: 20.78

      Secondary structure by segment:

     LELELELELELELHLELELELELHLELELELELELELHLELELHLHLELELHLHLHLHLH
     L

      Sequence and secondary structure:

   1 EDIIVVALYD YEAIHHEDLS FQKGDQMVVL EESGEWWKAR SLATRKEGYI 
        EEEESS  B   SSSB   BTTTTEEEES B TTTEEEEE ETTTT EEEE 

  51 PSNYVARVDS LETEEWFFKG ISRKDAERQL LAPGNMLGSF MIRDSETTKG 
     EGGGEEEGGG GGGGGGEESS  THHHHHHHH HTGGGGGGTE EEEE SSTTT 

 101 SYSLSVRDYD PRQGDTVKHY KIRTLDNGGF YISPRSTFST LQELVDHYKK 
     TEEEEEEEEE TTBSEEEEEE EEEEETTTEE ESTTTT BST HHHHHHHHHH 

 151 GNDGLCQKLS VPCMSSKPQK PWEKDAWEIP RESLKLEKKL GAGQFGEVWM 
     T  SSSS    SB           TTTT EET GGGEEE EE  EE SSEEEEE 

 201 ATYNKHTKVA VKTMKPGSMS VEAFLAEANV MKTLQHDKLV KLHAVVTKEP 
     EEEGGTEEEE EEEETTTTST HHHHHHHHHH HHHT TTTB   B EEE SSS 

 251 IYIITEFMAK GSLLDFLKSD EGSKQPLPKL IDFSAQIAEG MAFIEQRNYI 
     EEEEE  TTT TBHHHHHHHH HHHGGGHHHH HHHHHHHHHH HHHHHHTTT  

 301 HRDLRAANIL VSASLVCKIA DFGLARVGAK FPIKWTAPEA INFGSFTIKS 
      S  TGGGEE ETTTT EEE    S    SSS STGGGGGHHH HHHT  THHH 

 351 DVWSFGILLM EIVTYGRIPY PGMSNPEVIR ALERGYRMPR PENCPEELYN 
     HHHHHHHHHH HHHGGGT ST GGGGGHHHHH HHHTTT     TGGGGHHHHH 

 401 IMMRCWKNRP EERPTFEYIQ SVLDDFYTAT ESQ*QQQP 
     HHHHHT STG GGT THHHHH HHHHGGGGGG GGTB