Snapshot - 3LCK

MOL_ID: 1; MOLECULE: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE; CHAIN: NULL; FRAGMENT: PROTEIN TYROSINE KINASE DOMAIN; SYNONYM: LCK; EC: 2.7.1.112; ENGINEERED: YES; OTHER_DETAILS: PHOSPHORYLATION ON TYR 394

Compound summary followed by details of each entity.

Query Types: Text | Entity | Pattern | Load User List
Home | Contents | How it Works | Roadmap | Comments Please | Other Resources | Help


To review all results of the last query or to use them as an input for the next query click here


      Resolution: 1.70 Å                        Deposition Date: 08-APR-97

      Source: MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; 
              ORGANISM_COMMON: HUMAN; GENE: LCK; 
              EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA INSECT 
              CELLS; EXPRESSION_SYSTEM_CELL_LINE: SF9; 
              EXPRESSION_SYSTEM_CELLULAR_LOCATION: CYTOPLASM; 
              EXPRESSION_SYSTEM_VECTOR: BACULOVIRUS; 
              EXPRESSION_SYSTEM_PLASMID: PFASTBAC-1/BMON14272; 
              EXPRESSION_SYSTEM_GENE: POLYHEDRIN 
              
      Functional Class: TYROSINE-PROTEIN KINASE                 

      Authors: H.YAMAGUCHI,W.A.HENDRICKSON 
               
      Primary Citation: H.YAMAGUCHI,W.A.HENDRICKSON STRUCTURAL BASIS FOR 
                        ACTIVATION OF HUMAN LYMPHOCYTE KINASE LCK UPON 
                        TYROSINE PHOSPHORYLATION NATURE V. 384 484 1996 
                        ASTM NATUAS UK ISSN 0028-0836 0006 
                        
      Number of Entities: 1

Entity 3LCK:_

      Type: Protein                  Molecular Weight: 35993
      Number of Residues: 271
      Number of Alpha: 9             Content of Alpha: 38.75
      Number of Beta: 13             Content of Beta: 16.97

      Secondary structure by segment:

     LELELELELELHLELELHLHLHLELELELELELHLELHLHLHLHL

      Sequence and secondary structure:

   1 KPWWEDEWEV PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM 
      TGGGGGGB  TGGGEEE EE  EEETTEEEE EEEETTTEEE EEEEETHHHH 

  51 SPDAFLAEAN LMKQLQHQRL VRLYAVVTQE PIYIITEYME NGSLVDFLKT 
     HHHHHHHHHH HHHGT TTTB   B EEE SS S EEEEE TT TTBHHHHGGT 

 101 PSGIKLTINK LLDMAAQIAE GMAFIEERNY IHRDLRAANI LVSDTLSCKI 
     HHHHTTTHHH HHHHHHHHHH HHHHHHHTTE E S  TGGGE EETTTT EEE 

 151 ADFGLARLIE DNE*TAREGA KFPIKWTAPE AINYGTFTIK SDVWSFGILL 
       TTTTEE S SS EE TTTT   THHHHHHH HHHHTEETHH HHHHHHHHHH 

 201 TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER 
     HHHHTTT  S TTTTTHHHHH HHHHGTT     TTTTTHHHH HHHHHHTTST 

 251 PEDRPTFDYL RSVLEDFFTA T 
     GGGT THHHH HHHHHHHHHH T