Yeast Protein Kinases

The NCBI yeast sequence database currently contains 118 kinase-like sequences. This list of sequences was compiled in exactly the same way as the comprehensive kinase list. Every sequence in this list matches to at least one of the query sequences with a P-value<0.04. While this p-value is high enough that some non-kinases may be found,it is highly likely that sequences that match to more than one of the query panel or have lower p-values are kinase relatives. Note that some true kinase sequence, especially fragmentary or partial sequences, may be missed by this approach.

In the table below, Count is the number of distinct sequences in the query panel that matched with P<0.04. Score is the average BLAST comparison score for this sequence and all 57 sequences in the query panel (not just the matching ones). Max is the highest BLAST score observed with any member of the query panel. Results are sorted by Count, Max, and lowest P-value.

Michael Gribskov - 25 September 1997


Rank Sequence Count P-value Range Score Max Description
1 gi|508679 57 6.4e-118 0.0089 113.86 886 (U11581) Protein kinase; compo... 2 gnl|PID|e252297 57 2.9e-97 0.031 114.49 550 (Z74855) ORF YOL113w [Saccharo... 3 gi|536371 57 1e-71 0.028 108.30 330 (Z35897) ORF YBR028c; pid:g536... 4 gnl|PID|e252403 57 2.7e-62 0.0007 104.54 278 (Z75139) ORF YOR231w [Saccharo... 5 gi|1244775 57 3.8e-60 0.0025 102.75 283 (U43703) Mkk2p [Saccharomyces ... 6 gnl|PID|e318885 57 1.7e-58 0.00085 106.70 203 (Z49369) ORF YJL095w [Saccharo... 7 gnl|PID|e246929 57 3.6e-54 0.0033 109.86 252 (Z73565) ORF YPL209c [Saccharo... 8 gnl|PID|e247045 57 5.5e-51 0.023 89.11 185 (Z73509) ORF YPL153c [Saccharo... 9 gi|609414 57 1.4e-49 0.0061 111.00 242 (U19103) Ser/Thr protein kinas... 10 gi|1008270 57 6.7e-44 0.033 106.70 203 (Z49370) ORF YJL095w; pid:e201... 11 gi|536007 56 5.6e-111 0.033 97.14 420 (Z35777) ORF YBL016w; pid:g536... 12 gnl|PID|e246925 56 1.2e-108 0.0063 126.60 794 (Z73559) ORF YPL203w [Saccharo... 13 gi|1171426 56 3.8e-105 0.025 105.82 449 (U44030) Pho85p [Saccharomyces... 14 gi|1008352 56 5.1e-105 0.018 129.02 768 (Z49439) ORF YJL164c; pid:e201... 15 gnl|PID|e239731 56 6.7e-96 0.0068 111.39 545 (Z71574) ORF YNL298w [Saccharo... 16 gi|849169 56 1.2e-68 0.039 98.98 290 (U28371) Protein kinase (Swiss... 17 gi|927791 56 7.5e-53 0.021 95.19 197 (U33057) Sps1p: serine/threoni... 18 gnl|PID|e253223 56 8.3e-52 0.00078 84.82 155 (Z74149) ORF YDL101c [Saccharo... 19 gnl|PID|e251892 56 8.5e-50 0.0053 108.81 258 (Z74842) ORF YOL100w [Saccharo... 20 gi|927745 56 1.8e-48 0.011 102.04 220 (U33050) Ydr490cp; CAI: 0.11 [... 21 gi|1244774 56 2.5e-44 0.0029 100.35 218 (U43703) Lpi5p [Saccharomyces ... 22 gnl|PID|e239826 56 1e-41 0.002 98.33 200 (Z71646) ORF YNR031c [Saccharo... 23 gi|349757 56 6.3e-41 0.00037 101.91 217 (L22015) CDC15;YAR019 [Sacchar... 24 gnl|PID|e252094 56 4e-39 0.0041 99.21 239 (Z75141) ORF YOR233w [Saccharo... 25 gnl|PID|e264558 56 2.5e-34 0.012 97.77 195 (X59720) YCR073c, len:1314 [Sa... 26 gnl|PID|e243788 56 6.1e-32 0.00049 86.18 156 (Z72702) ORF YGL180w [Saccharo... 27 gi|486291 55 3.3e-103 0.012 128.19 755 (Z28166) ORF YKL166c [Saccharo... 28 gi|536178 55 3.3e-90 0.0038 112.32 482 (Z35866) ORF YBL105c; pid:g536... 29 gnl|PID|e264713 55 3.8e-85 0.0061 97.63 378 (X59720) YCR091w, len:726 [Sac... 30 gnl|PID|e239836 55 1.1e-80 0.017 97.54 353 (Z71662) ORF YNR047w [Saccharo... 31 gnl|PID|e253036 55 8.9e-76 0.0024 96.39 439 (Z74156) ORF YDL108w [Saccharo... 32 gi|927732 55 2e-63 0.0048 104.58 405 (U33050) Snf1p: serine/threoni... 33 gi|529127 55 2.7e-56 0.012 93.70 297 (U00059) similar to protein Se... 34 gi|927777 55 1.3e-55 0.0075 106.05 356 (U33057) Gin4p; CAI: 0.16 [Sac... 35 gnl|PID|e309035 55 3.5e-53 0.012 102.40 348 (X59720) YCL024w, len:915 [Sac... 36 gi|349756 55 2.4e-50 0.016 78.46 262 (L22015) protein kinase [Sacch... 37 gi|927730 55 3.5e-45 0.03 101.05 259 (U33050) Ydr466wp; CAI: 0.11 [... 38 gi|1332634 55 4.4e-45 0.019 94.05 163 (U51030) Gcn2p: Protein kinase... 39 gi|747896 54 1.5e-172 0.028 113.19 1109 (Z48758) Kin1p [Saccharomyces ... 40 gi|535469 54 1.3e-124 0.012 111.82 731 (X80224) protein kinase [Sacch... 41 gnl|PID|e243401 54 5.2e-111 0.0045 94.40 312 (Z72825) ORF YGR040w [Saccharo... 42 gi|1256876 54 3.3e-100 0.0058 101.61 325 (U53878) Mitogen activated and... 43 gnl|PID|e245558 54 3.3e-100 0.0058 101.61 325 (Z73285) ORF YLR113w [Saccharo... 44 gi|488177 54 1.1e-91 0.0015 97.33 418 (U00062) Similar to KSS1 and o... 45 gi|805035 54 7.5e-74 0.014 95.07 216 (Z49219) Smk1p [Saccharomyces ... 46 gnl|PID|e239962 54 1.3e-72 0.029 104.26 332 (Z71437) ORF YNL161w [Saccharo... 47 gi|486235 54 2.4e-71 0.016 103.18 215 (Z28139) ORF YKL139w [Saccharo... 48 gi|536713 54 5.3e-66 0.025 78.42 225 (Z36143) ORF YBR274w; pid:g536... 49 gnl|PID|e253067 54 1.1e-65 0.0052 80.51 329 (Z74207) ORF YDL159w [Saccharo... 50 gnl|PID|e252260 54 3e-62 0.013 88.93 381 (Z74758) ORF YOL016c [Saccharo... 51 gnl|PID|d1009894 54 1.2e-58 0.024 87.89 338 (D50617) Calcium/Calmodulin-de... 52 gi|486169 54 2.1e-56 0.031 91.19 269 (Z28101) ORF YKL101w [Saccharo... 53 gi|728648 54 8.5e-39 0.00044 102.23 210 (Z48613) Cdc5p [Saccharomyces ... 54 gnl|PID|e247044 54 1.3e-37 0.013 93.46 292 (Z73506) ORF YPL150w [Saccharo... 55 gnl|PID|e243787 54 1.8e-26 0.0037 91.75 133 (Z72701) ORF YGL179c [Saccharo... 56 gi|603368 54 4.2e-26 0.023 88.19 126 (U18916) Pak1p: DNA polymerase... 57 gi|1256846 53 9e-154 0.0058 115.96 1129 (U53876) Probable Serine/Threo... 58 gi|486213 53 4.3e-92 0.02 119.53 532 (Z28126) ORF YKL126w [Saccharo... 59 gi|817862 53 1.5e-90 0.035 119.18 526 (Z49702) Ypk2p [Saccharomyces ... 60 gi|1171416 53 4.1e-56 0.03 84.95 178 (U44030) Srb10p [Saccharomyces... 61 gnl|PID|e243437 52 1.4e-172 0.033 96.14 697 (Z72877) ORF YGR092w [Saccharo... 62 gi|914982 52 3.3e-158 0.04 95.77 644 (U32445) Ser/Thr protein kinas... 63 gnl|PID|e252175 52 7.7e-41 0.034 66.68 142 (Z75259) ORF YOR351c [Saccharo... 64 gnl|PID|e253196 52 1.2e-21 0.03 77.40 140 (Z74073) ORF YDL025c [Saccharo... 65 gi|486194 52 2.7e-17 0.026 63.88 120 (Z28115) ORF YKL116c [Saccharo... 66 gi|486354 52 3.7e-13 0.04 78.65 128 (Z28198) ORF YKL198c [Saccharo... 67 gi|458923 51 6.2e-182 0.034 111.70 745 (U00029) cAMP-dependent protei... 68 gi|1015729 51 2.1e-11 0.015 80.74 136 (Z49559) ORF YJR059w [Saccharo... 69 gi|486281 50 5.2e-82 0.03 83.95 356 (Z28161) ORF YKL161c [Saccharo... 70 gi|662336 50 1.9e-51 0.025 75.32 229 (U20865) Serine/Threonine prot... 71 gnl|PID|e252116 50 1.6e-19 0.022 72.75 124 (Z75175) ORF YOR267c [Saccharo... 72 gi|171858 50 6.9e-18 0.019 80.91 150 (L05146) serine/threonine kina... 73 gnl|PID|e239758 49 3.2e-85 0.034 77.77 564 (Z71583) ORF YNL307c [Saccharo... 74 gnl|PID|d1009846 49 1.2e-55 0.039 92.37 260 (D50617) unknown [Saccharomyce... 75 gi|1008288 49 1.6e-37 0.029 71.09 199 (Z49381) ORF YJL106w [Saccharo... 76 gnl|PID|e251858 49 1.4e-21 0.037 76.26 154 (Z74788) ORF YOL045w [Saccharo... 77 gnl|PID|e253265 49 1.3e-19 0.037 67.33 133 (Z74262) ORF YDL214c [Saccharo... 78 gnl|PID|e239556 49 1.6e-17 0.012 74.42 140 (Z71459) ORF YNL183c [Saccharo... 79 gnl|PID|e264471 48 1e-27 0.0073 80.86 176 (X59720) YCR008w, len:603 [Sac... 80 gnl|PID|e243411 48 3e-18 0.014 69.79 137 (Z72837) ORF YGR052w [Saccharo... 81 gnl|PID|e243774 47 2.6e-47 0.033 71.33 210 (Z72680) ORF YGL158w [Saccharo... 82 gi|1008354 45 1.6e-22 0.036 65.49 144 (Z49440) ORF YJL165c; pid:e201... 83 gi|500837 44 1.8e-175 0.038 70.95 859 (U10556) Probable protein kina... 84 gi|1008328 42 1.1e-80 0.031 48.46 240 (Z49403) ORF YJL128c [Saccharo... 85 gi|1008395 42 2.2e-67 0.036 54.39 207 (Z49462) ORF YJL187c; pid:e201... 86 gi|486147 42 3.3e-15 0.021 58.18 126 (Z28048) ORF YKL048c [Saccharo... 87 gi|530348 41 2.1e-24 0.034 50.63 105 (X80836) serine/threonine kina... 88 gi|536299 41 7.7e-10 0.039 48.07 87 (Z35928) ORF YBR059c; pid:g536... 89 gnl|PID|e239868 40 1.4e-18 0.04 46.67 87 (Z71296) ORF YNL020c [Saccharo... 90 gi|817833 40 7.5e-17 0.028 58.63 114 (Z49701) unknown [Saccharomyce... 91 gnl|PID|e251913 39 1.1e-60 0.031 62.21 381 (Z74870) ORF YOL128c [Saccharo... 92 gi|500839 38 2.9e-12 0.039 52.32 117 (U10556) Similar to casein kin... 93 gi|600013 37 4.1e-125 0.037 62.42 729 (Z46861) casein kinase II alph... 94 gi|1039451 36 1.9e-14 0.024 51.75 118 (U36624) Sha3p [Saccharomyces ... 95 gnl|PID|e252977 35 1.1e-23 0.033 46.09 137 (Z74065) ORF YDL017w [Saccharo... 96 gi|486300 34 8.8e-13 0.029 41.88 100 (Z28171) ORF YKL171w [Saccharo... 97 gnl|PID|e247075 34 4.2e-09 0.04 36.21 96 (Z73592) ORF YPL236c [Saccharo... 98 gi|1008199 34 5.8e-09 0.035 42.14 98 (Z49332) ORF YJL057c; pid:e201... 99 gi|1015551 32 6e-41 0.033 46.28 167 (Z49417) ORF YJL141c; pid:e203... 100 gi|486295 32 6.7e-21 0.019 48.05 140 (Z28168) ORF YKL168c [Saccharo... 101 gnl|PID|e252984 32 4e-15 0.026 39.00 103 (Z74076) ORF YDL028c [Saccharo... 102 gnl|PID|e322112 31 5e-74 0.022 45.58 309 (Z73123) ORF YLL019c [Saccharo... 103 gnl|PID|e245455 30 6.7e-83 0.023 44.74 309 (Z73125) ORF YLL019c [Saccharo... 104 gnl|PID|e252339 28 8.3e-114 0.0059 53.68 688 (Z74969) ORF YOR061w [Saccharo... 105 gi|854468 27 4.9e-34 0.026 31.60 144 (Z49809) unknown [Saccharomyce... 106 gi|606437 26 6.2e-126 0.013 47.65 559 (Z47071) serine/threonine prot... 107 gnl|PID|d1009850 26 1e-12 0.037 36.86 105 (D50617) unknown [Saccharomyce... 108 gnl|PID|e253215 23 1.3e-116 0.015 40.65 489 (Z74127) ORF YDL079c [Saccharo... 109 gnl|PID|e247063 17 6.3e-128 0.033 35.68 927 (Z73560) ORF YPL204w [Saccharo... 110 gi|536462 17 1.5e-07 0.025 21.70 83 (Z35966) ORF YBR097w; pid:g536... 111 gi|500684 14 6.5e-95 0.037 23.25 402 (U10398) Casein kinase I homol... 112 gnl|PID|e239958 12 4.8e-94 0.03 21.14 397 (Z71430) ORF YNL154c [Saccharo... 113 gnl|PID|e243726 10 0.00048 0.032 12.81 82 (Z72973) ORF YGR188c [Saccharo... 114 gi|603362 9 5.6e-88 0.04 15.26 303 (U18916) Yck3p: Plasma membran... 115 gnl|PID|e243969 9 1.4e-05 0.029 9.35 72 (Z72605) ORF YGL083w [Saccharo... 116 gi|914977 4 2.7e-05 0.012 4.93 78 (U32445) Similar to protein ki... 117 gi|603421 1 0.008 0.008 1.28 73 (U18922) Isc10p [Saccharomyces... 118 gnl|PID|e243850 1 0.013 0.013 1.26 72 (Z72543) ORF YGL021w [Saccharo...