Hanks Classification

Protein Kinase Classification provided by:
Steven K. Hanks
Vanderbilt University
April 1, 1994

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The following classification has been condensed from material provided by Steve Hanks. It represents an attempt to organize the known members of the eukaryotic protein kinase superfamily into distinct families that share basic structural and functional properties. The primary criterion used in the development of this classification scheme is similarity in catalytic domain amino acid sequence. This property, considered alone, has proven to be a good indicator of other features held in common by the different members of a family. Thus kinases having closely-related catalytic domains tend also to: 1) be similar in overall structural topology, 2) have similar modes of regulation, and 3) have similar substrate specificities.

  1. AGC Group

    1. AGC Group I
      Cyclic nucleotide regulated protein kinase (PKA & PKG) family
    2. AGC Group II
      Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family
    3. AGC Group III
      Related to PKA and PKC (RAC/Akt) protein kinase family
    4. AGC Group IV
      Kinases that phoshorylate G protein-coupled receptors family
    5. AGC Group V
      Budding yeast AGC-related protein kinase family
    6. AGC group VI
      Kinases that phosphorylate ribosomal protein S6 family
    7. AGC Group VII
      Budding yeast DBF2/20 family
    8. AGC Group VIII
      Flowering plant PVPK1 protein kinase homolog family
    9. AGC Group Other
      Other AGC related kinase families

  2. CaMK Group

    1. CaMK Group I
      Kinases regulated by Ca2+/CaM and close relatives family
    2. CaMK Group II
      KIN1/SNF1/Nim1 family
    3. CaMK Other
      Other CaMK related kinase families

  3. CMGC Group

    1. CMGC Group I
      Cyclin-dependent kinases (CDKs) and close relatives family
    2. CMGC Group II
      ERK (MAP) kinase family
    3. CMGC Group III
      Glycogen synthase kinase 3 (GSK3) family
    4. CMGC Group IV
      Casein kinase II family
    5. CMGC Group V
      Clk family
    6. CMGC Group Other

  4. PTK Group - `Conventional' protein-tyrosine kinases

  5. Group I-IX Non-membrane spanning protein-tyrosine kinases
    Group IX-XXI membrane spanning protein-tyrosine kinases

    1. PTK group I
      Src family
    2. PTK Group II
      Tec/Atk family
    3. PTK Group III
      Csk family
    4. PTK Group IV
      Fes (Fps) family
    5. PTK Group V
      Abl family
    6. PTK Group VI
      Syk/ZAP70 family
    7. PTK Group VII
      Tyk2/Jak1 family
    8. PTK Group VIII
      Ack family
    9. PTK Group IX
      Focal adhesion kinase (Fak) family
    10. PTK Group X
      Epidermal growth factor receptor family
    11. PTK Group XI
      Eph/Elk/Eck receptor family
    12. PTK Group XII
      Axl family
    13. PTK Group XIII
      Tie/Tek family
    14. PTK Group XIV
      Platelet-derived growth factor receptor family
    15. PTK Group XV
      Fibroblast growth factor receptor family
    16. PTK Group XVI
      Insulin receptor family
    17. PTK Group XVII
      LTK/ALK family
    18. PTK Group XVIII
      Ros/Sevenless family
    19. PTK Group XIX
      Trk/Ror family
    20. PTK Group XX
      DDR/TKT family
    21. PTK Group XXI
      Hepatocyte growth factor receptor family
    22. PTK Group XXII
      Nematode Kin15/16 family
    23. PTK Other membrane spanning kinases
      Other PTK kinase families

  6. OPK Group - Other protein kinases (not falling in major groups)

    1. OPK Group I
      Polo family
    2. OPK Group II
      MEK/STE7 family
    3. OPK Group III
      PAK/STE20 family
    4. OPK Group IV
      MEKK/STE11 family
    5. OPK Group V
      NimA family
    6. OPK Group VI
      wee1/mik1 family
    7. OPK Group VII
      Kinases involved in transcriptional control family
    8. OPK Group VIII
      Raf family
    9. OPK Group IX
      Activin/TGFb receptor family
    10. OPK Group X
      Flowering plant putative receptor kinases and close relatives family
    11. OPK Group XI
      PSK/PTK "mixed lineage" leucine zipper domain family
    12. OPK Group XII
      Casein kinase I family
    13. OPK Group XIII
      PKN prokaryotic protein kinase family
    14. OPK Other
      Other protein kinase families (each with no close relatives)

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Last modified Wednesday, 31 December 2069 by Anonymous