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Dr. Steven Hanks and Anne Marie Quinn have kindly provided the following expert multiple alignment of 390 protein kinase sequences. It represents an attempt to organize the known members of the eukaryotic protein kinase superfamily into distinct families that share basic structural and functional properties. The primary criterion used in the development of this classification scheme is similarity in catalytic domain amino acid sequence. This property, considered alone, has proven to be a good indicator of other features held in common by the different members of a family. Thus kinases having closely-related catalytic domains tend also to: 1) be similar in overall structural topology, 2) have similar modes of regulation, and 3) have similar substrate specificities. Only protein kinases whose entire catalytic domain amino acid sequence has been published or made available through one of the sequence databases have been included in the alignment.

This work was reported in the following article:

S. Hanks and A.M. Quinn. Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members. Methods in Enzymology 200, 38-62, 1991.

The numbering given below corresponds to the cAPKa sequence. The original sequence and references for each entry in the alignment can be found by clicking on the sequence name (the lefthand field in each sequence line). Each group label is linked to the classification page. Links within the sequence itself will bring up views of the molecule indicating where the corresponding block of sequence is located.


AGC Group I

Cyclic nucleotide regulated protein kinase family

Hank's 
Conserved            I                                  II                        III                                                   IV                           V                        VIa                                 VIb                     VII                               VIII                     IX                                     X                                                                          XI
Regions

Function         Phosphate                                                                                                                                                                                                    Catalytic                          |<---- Activation ----->|<- P+1 ->| 
                  Anchor                                                                                                                                                                                                        Region                                    Loop               Loop
           43                  64              65               83          84           98         99          113         114      125  126      137                             138                 160               161            178         179         193                   194           210      211           226 227         240       241                260                                       261                         290  291 297
           |                    |              |                 |          |             |         |             |         |          |  |          |                             |                     |               |                |         |             |                   |               |      |               | |             |       |                    |                                       |                             |  |     |
cAPKa      FERIKTLGTGSFGRVMLVKHKE--------------TGNHYAMKILDKQKVVKLK----------QIEHTLNEKRILQAV---------NFPFLVKLEFSFKDN---------SNLYMVMEYVPG--GEMFSHLRRIGR-----------------------------FSEPHARFYAAQIVLTFEYLHSL---------------DLIYRDLKPENLLIDQQG---------YIQVTDFGFAKRVKG-------------------RTWTLCGTPEYLAPEII------LSKGYNK-AVDWWALGV-LIYEMAA-GYPPFFA-------DQPIQIYEKIVSG-KV-RFPSH---------------------------------------FSSDLKD-LLRNLLQVDLTKRFGNLKNGVND--IKNHKWF
cAPKb      FERKKTLGTGSFGRVMLVKHKA--------------TEQYYAMKILDKQKVVKLK----------QIEHTLNEKRILQAV---------NFPFLVRLEYAFKDN---------SNLYMVMEYVPG--GEMFSHLRRIGR-----------------------------FSEPHARFYAAQIVLTFEYLHSL---------------DLIYRDLKPENLLIDHQG---------YIQVTDFGFAKRVKG-------------------RTWTLCGTPEYLAPEII------LSKGYNK-AVDWWALGV-LIYEMAA-GYPPFFA-------DQPIQIYEKIVSG-KV-RFPSH---------------------------------------FSSDLKD-LLRNLLQVDLTKRFGNLKNGVSD--IKTHKWF
cAPKg      FERLRTLGMGSFGRVMLVRHQE--------------TGGHYAMKILNKQKVVKMK----------QVEHILNEKRILQAI---------DFPFLVKLQFSFKDN---------SYLYLVMEYVPG--GEMFSRLQRVGR-----------------------------FSEPHACFYAAQVVLAVQYLHSL---------------DLIHRDLKPENLLIDQQG---------YLQVTDFGFAKRVKG-------------------RTWTLCGTPEYLAPEII------LSKGYNK-AVDWWALGV-LIYEMAV-GFPPFYA-------DQPIQIYEKIVSG-RV-RFPSK---------------------------------------LSSDLKD-LLRSLLQVDLTKRFGNLRNGVGD--IKNHKWF
EcAPKa     FDRIKTLGTGSFGRVMLVKHKQ--------------SGNYYAMKILDKQKVVKLK----------QVEHTLNEKRILQAI---------DFPFLVNMTFSLKDN---------SNLYMVLEFISG--GEMFSHLRRIGR-----------------------------FSEPHSRFYAAQIVLAFEYLHSL---------------DLIYRDLKPENLLIDSTG---------YLKVTDFGFAKRVKG-------------------RTWTLCGTPEYLAPEII------LSKGYNK-AVDWWALGV-LIYEMAA-GYPPFFA-------DQPIQIYEKIVSG-KV-KFPSH---------------------------------------FSNELKD-LLKNLLQVDLTKRYGNLKNGVAD--IKNHKWF
DC0        FERIKTLGTGSFGRVMIVQHK---------------PTKDYAMKILDKQKVVKLK----------QVEHTLNEKRILQAI---------QFPFLVSLRYHFKDN---------SNLYMVLEYVPG--QEMFSHLRKVGR-----------------------------FSEPHSRFYAAQIVLAFEYLHYL---------------DLIYRDLKPENLLIDSQG---------YLKVTDFGFAKRVKG-------------------RTWTLCGTPEYLAPEII------LSKGYNK-AVDWWALGV-LVYEMAA-GYPPFFA-------DQPIQIYEKIVSG-KV-RFPSH---------------------------------------FGSDLKD-LLRNLLQVDLTKRYGNLKAGVND--IKNQKWF
DC1        YITRAVLGNGSFGTVMLVREKS--------------GKNYYAAKMMSKEDLVRLK----------QVAHVHNEKHVLNAA---------RFPFLIYLVDSTKCF---------DYLYLILPLVNG--GELESYHRRVRK-----------------------------FNEKHARFYAAQVALALEYMHKM---------------HLMYRDLKPENILLDQRG---------YLKVTDFGFAKRVKG-------------------RTSTLCGTPEYLAPEIV------QLRPYNK-SVDWWAFGI-LVYEFVA-GRSPFAIHN-----RDVILMYSKICIC-DY-KMPSY---------------------------------------FTSQLRS-LVESLMQVDTSKRLGNSNDGSSD--VKSHPWF
DC2        YQIIKTVGTGTFGRVCLCRVRI--------------SEKYCAMKILAMTEVIRLK----------QIEHVKNERNILREI---------RHPFVISLEWSTKDD---------SNLYMIFDYVCG--GELFTYLRNAGK-----------------------------FTSQTSNFYAAEIVSALEYLHSL---------------QIVYRDLKPENLLINRDG---------YIKITDFGETKRVDG-------------------RTWTLCGTPEYIAPEII------QSKGHNK-AVDWWALGV-LIYEMLV-GYPPFYD-------EQPFGIYEKILSG-KI-EWERH---------------------------------------MDPIAKD-LIKKLLVNDRTKRLGNMKNGADD--VKRHRWF
AplC       FNRIKTLGTGSFGRVMLVQHKGE-------------SRNFYAMKILDKQKVVKLK----------QVEHTLNEKKILQSI---------DFPFLVKLEYSFKDN---------SNLYMVLEFVTG--GEMFSHLRRIGR-----------------------------FSEPHSRFYAAQIVLVLEYLHHL---------------DIMYRDLKPENLLIDSYG---------HLKITDFGFAKKLRD-------------------RTWTLCGTPEYLAPEII------LSKGYDK-AVDWWALGV-LIYEMAA-GYPPFFA-------DEPIQIYEKIVSG-KV-RFPSH---------------------------------------FSSDLKD-EERNLLQVDLTKRFGDLKDGVND--IKNHKWF
SAK        YTLIRTLGSGSFGRVMLSQHGGDN------------PQKCYAIKILNKEKVVKMK----------QVEHTMNEKRILLSI---------GSPFVVRCLNAFKDT---------TNLYMVMEFVNG--GELFHLLRKKGR-----------------------------LPEYWCTFYAAQVTMALQYLHNC---------------SLLYRDLKPENILLDHLG---------YLKVTDFGFDRRVQG-------------------HTWTLCGTPQYLAPEMI------LNRSYAS-QWTTGGLGI-LIYELNA-GFVPFDH-------KVPLKLYELIVEC-RL-TFPSF---------------------------------------FKPTLRD-LLTNIIQVDVTRRFGNLRNGALD--IINHPWF
DdPK1      FNFYGSLGSGSFGTAKLCRHRG--------------SGLFFCSKTLRRETIVHEK----------HKEHVNNEINIMLNI---------SHPYIVKTYSTFNTP---------TKIHFIMEYAGK--KDLFHHLRANKC-----------------------------FTEQTTKLIVAEIVLAIEYLHAE---------------NIIYRDLKPENILIDEKG---------HIKLTDFGFSKKTVGG------------------KNTSSCGTFDYMAPEILN-----SSNGHGK-PVDWWALGV-VVYELVT-GKLPFSN-------SKESLLNRKADFQ-LI-FQNSY---------------------------------------LSDEIKD-FIFQLLSVDPSKRLGTFDSCS----IRNHKWF
DdPK2      FKQIRVLGTGTFGKVYLIQNTK--------------DGCYYAMKCLNKAYVVQLK----------QVEHLNSEKSILSSI---------HHPFIVNLYQAFQDE---------KKLYLLFEYVAG--GEVFTHLRKSMK-----------------------------FSNSTAKFYAAEIVLALEFLHKQ---------------NIVYRDLKPENLLIDNQG---------HIKITDFGFAKRVED-------------------RTFTLCGTPEYLAPEII------QSKGHGK-AVDWWALGI-LIFEMLA-GYPPFYD-------DDTFAIYNKILAG-RI-TFPLG---------------------------------------FDVDAKD-LIKRLLTADRTRRLGALKDGALD--VKNHRWF
TPK1       FQILRTLGTGSFGRVHLIRSRH--------------NGRYYAMKVLKKEIVVRLK----------QVEHTNDERLMLSIV---------THPFIIRMWGTFQDA---------QQIFMIMDYIEG--GELFSLLRKSQR-----------------------------FPNPVAKFYAAEVCLALEYLHSK---------------DIIYRDLKPENILLDKNG---------HIKITDFGFAKYVPD-------------------VTYTLCGTPDYIAPEVV------STKPYNK-SIDWWSFGI-LIYEMLA-GYTPFYD-------SNTMKTYEKILNA-EL-RFPPF---------------------------------------FNEDVKD-LLSRLITRDLSQRLGNLQNGTED--VKNHPWF
TPK2       FQIMRTLGTGSFGRVHLVRSVH--------------NGRYYAIKVLKKQQVVKMK----------QVEHTNDERRMLKLV---------EHPFLIRMWGTFQDA---------RNIFMVMDYIEG--GELFSLLRKSQR-----------------------------FPNPVAKFYAAEVILALEYLHAH---------------NIIYRDLKPENILLDRNG---------HIKITDFGFAKEVQT-------------------VTWTLCGTPDYIAPEVI------TTKPYNK-SVDWWSLGV-LIYEMLA-GYTPFYD-------TTPMKTYEKILQG-KV-VYPPY---------------------------------------FQPDVVD-LLSKLITADLTRRIGNLQSGSRD--IKAHPWF
TPK3       FQILRTLGTGSFGRVHLIRSNH--------------NGRFYALKTLKKHTIVKLK----------QVEHTNDERRMLSIV---------SHPFIIRMWGTFQDS---------QQVFMVMDYIEG--GELFSLLRKSQR-----------------------------FPNPVAKFYAAEVCLALEYLHSK---------------DITYRDLKPENILLDKNG---------HIKITDFGFAKYVPD-------------------VTYTLCGTPDYIAPEVV------STKPYNK-SVDWWSFGV-LIYEMLA-GYTPFYN-------SNTMKTYENILNA-EL-KFPPF---------------------------------------FHPDAQD-LLKKLITRDLSERLGNLQNGSED--VKNHPWF
B.emC      LELRQTLGTGSFGRVHLVRLRS--------------TGKYYAMKVLKKAEVVKHK----------QVEHTLNEKGILEQI---------DHPFLVALHSSFQDS---------ANLYMVMEYVTG--GELFTYLRRSQR-----------------------------FSNNVAKFYAAEVVLAFEYLHSK---------------DIIYRDLKPENLLLDAQG---------HVKITDFGFAKHVPD-------------------ITWTLCGTPDYLAPEII------QSRGYGR-AVDWYALGV-LIFEMLA-GYPPFYD-------EDHVRMYEKILQG-KV-KWPSH---------------------------------------FDPAAKD-LLKRLLTTDLTKRYGNLKGGSKD--IKMHKWF
PKG-I      FNIIDTLGVGGFGRVELVQLKSE-------------ESKTFAMKILKKRHIVDTR----------QQEHIRSEKQIMQGA---------HSDFIVRLYRTFKDS---------KYLYMLMEACLG--GELWTILRDRGS-----------------------------FEDSTTRFYTACVVEAFAYLHSK---------------GIIYRDLKPENLILDHRG---------YAKLVDFGFAKKIGFGK-----------------KTWTFCGTPEYVAPEII------LNKGHDI-SADYWSLGI-LMYELLT-GSPPFSG-------PDPMKTYNIILRGIDMIEFPKK---------------------------------------IAKNAAN-LIKKLCRDNPSERLGNLKNGVKD--IQKHKWF
PKG-II     LEIIATLGVGGFGRVELVKVKN--------------ENVAFAMKCIRKKHIVDTK----------QQEHVYSEKRILEEL---------CSPFIVKLYRTFKDN---------KYVYMLLEACLG--GELWSILRDRGS-----------------------------FDEPTSKFCVACVTEAFDYLHLL---------------GIIYRDLKPENLILDADG---------YLKLVDFGFAKKIGSGQ-----------------KTWTFCGTPEYVAPEVI------LNKGHDF-SVDFWSLGI-LVYELLT-GNPPFSG-------IDQMMTYNLILKGIEKMDFPRK---------------------------------------ITRRPED-LIRRLCRQNPTERLGNLKNGIND--IKKHRWL
DG1        LEVVSTLGIGGFGRVELVKAHHQD------------RVDIFALKCLKKRHIVDTK----------QEEHIFSERHIMLSS---------RSPFICRLYRTFRDE---------KYVYMLLEACMG--GEIWTMLRDRGS-----------------------------FEDNAAQFIIGCVLQAFEYLHAR---------------GIIYRDLKPENLMLDERG---------YVKIVDFGFAKQIGTSS-----------------KTWTFCGTPEYVAPEII------LNKGHDR-AVDYWALGI-LIHELLN-GTPPFSA-------PDPMQTYNLILKGIDMIAFPKH---------------------------------------ISRWAVQ-LIKRLCRDVPSERLGYQTGGIQD--IKKHKWF
DG2        LRVIATLGVGGFGRVELVQTNGD-------------SSRSFALKQMKKSQIVETR----------QQQHIMSEKEIMGEA---------NCQFIVKLFKTFKDK---------KYLYMLMESCLG--GELWTILRDKGN-----------------------------FDDSTTRFYTACVVEAFDYLHSR---------------NIIYRDLKPENLLLNERG---------YGKLVDFGFAKKLQTGR-----------------KTWTFCGTPEYVAPEVI------LNRGHDI-SADYWSLGV-LMFELLT-GTPPFTG-------SDPMRTYNIILKGIDAIEFPRN---------------------------------------ITRNASN-LIKKLCRDNPAERLGYQRGGISE--IQKHKWF


AGC Group II

Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family

PKCa       FNFLMVLGKGSFGKVMLADRKG--------------TEELYAIKILKKDVVIQDD----------DVECTMVEKRVLALLD--------KPPFLTQLHSCFQTV---------DRLYFVMEYVNG--GDLMYHIQQVGK-----------------------------FKEPQAVFYAAEISIGLFFLHKR---------------GIIYRDLKLDNVMLDSEG---------HIKIADFGMCKEHMMDGV----------------TTRTFCGTPDYIAPEII------AYQPYGK-SVDWWAYGV-LLYEMLA-GQPPFDG-------EDEDELFQSIMEH-NV-SYPKS---------------------------------------LSKEAVS-ICKGLMTKHPAKRLGCGPEGERD--VREHAFF
PKCb       FNFLMVLGKGSFGKVMLSERKG--------------TDELYAVKILKKDVVIQDD----------DVECTMVEKRVLALPG--------KPPFLTQLHSCFQTM---------DRLYFMMEYVNG--GDLMYHIQQVGR-----------------------------FKEPHAVFYAAEIAIGLFFLQSK---------------GIIYRDLKLDNVMLDSEG---------HIKIADFGMCKENIWDGV----------------TTKTFCGTPDYIAPEII------AYQPYGK-SVDWWAFGV-LLYEMLA-GQAPFEG-------EDEDELFQSIMEH-NV-AYPKS---------------------------------------MSKEAVA-ICKGLMTKHPGKRLGCGPEGERD--IKEHAFF
PKCg       FSFLMVLGKGSFGKVMLAERRG--------------SDELYAIKILKKDVIVQDD----------DVDCTLVEKRVLALGGRGPGG---RPHFLTQLHSTFQTP---------DRLYFVMEYVTG--GDLMYHIQQLGK-----------------------------FKEPHAAFYAAEIAIGLFFLHNQ---------------GIIYRDLKLDNVMLDAEG---------HIKITDFGMCKENVFPGS----------------TTRTFCGTPDYIAPEII------AYQPYGK-SVDWWSFGV-LLYEMLA-GQPPFDG-------EDEEELFQAIMEQ-TV-TYPKS---------------------------------------LSREAVA-ICKGFLTKHPGKRLGSGPDGEPT--IRAHGFF
DPKC53b    FNFIKVLGKGSFGKVLLAERKG--------------SEELYAIKILKKDVIIQDD----------DVECTMIEKRVLALGE--------KPPFLVQLHSCFQTM---------DRLFFVMEYVNG--GDLIFQIQQFGK-----------------------------FKEPVAVFYAAEIAAGLFFLHTK---------------GILYRDLKLDNVLLDADG---------HVKIADFGMCKENIVGDK----------------TTKTFCGTPDYIAPEII------LYQPYGK-SVDWWAYGV-LLYEMLV-GQPPFDG-------EDEEELFAAITDH-NV-SYPKS---------------------------------------LSKEAKE-ACKGFLTKQPNKRLGCGSSGEED--VRLHPFS
DPKC53e    FNFVKVIGKGSFGKVLLWERRG--------------TDELYAVKVLRKDVIIQTD----------DMELPMNEKKILALSG--------RPPFLVSMHSCFQTM---------DRLFFVMEYCKG--GDLMYHMQQYGK-----------------------------FKESVAIFYAVEVAIALFFLHER---------------DIIYRDLKLDNILLDGEG---------HVKLVDFGLSKEGVTERQ----------------TTRTFCGTPNYMAPEIV------SYDPYSI-AADWWSFGV-LLFEFMA-GQAPFEG-------DDETTVFRNIKDK-KA-VFPKH---------------------------------------FSVEAMD-IITSFLTKKPNNRLGAGRYARQE--ITTHPFF
AplI       FNFLTVLGKGSFGKVVLAERKG--------------TDELYAIKILKKDVIIQDD----------DVECTMIEKRVLALPD--------KPPFLVQLHSCFQTM---------DRLYFVMEYVNG--GDLMYRIQQEGK-----------------------------FKEPVAAFYAAEIAIGLFYLHTQ---------------GIVYRDLKLDNVMLDAEG---------HIKIADFGMCKENIMGDK----------------TTRTFCGTPDYIAPEIV------LYQPYGR-SVDWWAYGV-LLYEMLA-GQPPFDG-------EDEEELFTSITDH-NV-SYPKA---------------------------------------LSREAVS-LCKGLLTKTPAKRLGCGPNGERD--IKDRAFF

PKCd       FTFQKVLGKGSFGKVLLAELKG--------------KERYFAIKYLKKDVVLIDD----------DVECTMVEKRVLALAW--------ENPFLTHLICTFQTK---------DHLFFVMEFLNG--GDLMFHIQDKGR-----------------------------FELYRATFYAAEIICGLQFLHGK---------------GIIYRDLKLDNVMLDKDG---------HIKIADFGMCKENIFGEN----------------RASTFCGTPDYIAPEIL------QGLKYSF-SVDWWSFGV-LLYEMLI-GQSPFHG-------DDEDELFESIRVD-TP-HYPRW---------------------------------------ITKESKD-IMEKLFERDPAKRLGVTGN------IRLHPFF
PKCe       FNFIKVLGKGSFGKVMLAELKG--------------KDEVYAVKVLKKDVILQDD----------DVDCTMTEKRILALAR--------KHPYLTQLYCCFQTK---------DRLFFVMEYVNG--GDLMFQIQRSRK-----------------------------FDEPRSGFYAAEVTSALMFLHQH---------------GVIYRDLKLDNILLDAEG---------HSKLADFGMCKEGILNGV----------------TTTTFCGTPDYIAPEIL------QELEYGP-SVDWWALGV-LMYEMMA-GQPPFEA-------DNEDDLFESILHD-DV-LYPVW---------------------------------------LSKEAVS-ILKAFMTKNPHKRLGCAAQNGEDA-IKQHPFF
PKCet      FEFIRVLGKGSFGKVMLARVKE--------------TGDLYAVKVLKKDVILLDD----------DVECTMTEKRILSLAR--------NHPFLTQLFCCFQTP---------DRLFFVMEFVNG--GDLMFHIQKSRR-----------------------------FDEARARFYAAEIISALMFLHDK---------------GIIYRDLKLDNVLLDHEG---------HCKLADFGMCKEGICNGV----------------TTATFCGTPDYIAPEIL------QEMLYGP-AVDWWAMGV-LLYEMLC-GHAPFEA-------ENEDDLFEAILND-EV-VYPTW---------------------------------------LHEDATG-ILKSFMTKNPTMRLGSLTQGGEHAILR-HPFF
PKCth      FILHKMLGKGSFGKVFLAEFKR--------------TNGFFAIKALKKDVVLMDD----------DVECTMVEKRVLSLAW--------EHPFLTHMFCTFQTK---------ENLFFVMEYLNG--GDLMYHIQSCHK-----------------------------FDLSRATFYAAEVILGLQFLHSK---------------GIVYRDLKLDNILLDRDG---------HIKIADFGMCKENMLGDA----------------KTNTFCGTPDYIAPEIL------LGQKYNH-SVDWWSFGV-LVYEMLI-GQSPFHG-------QDEEELFHSIRMD-NP-FYPRW---------------------------------------LEREAKD-LLVKLFVREPEKRLGVRGD------IRQHPLF
DPKC98     FNFIKVLGKGSFGKVMLAEKKG--------------TDEIYAIKVLKKDAIIQDD----------DVDCTMTEKRILALAA--------NHPFLTALHSCFQTP---------DRLFFVMEYVNG--GDLMFQIQKARR-----------------------------FEASRAAFYAAEVTLALQFLHTH---------------GVIYRDLKLDNILLDQEG---------HCKLADFGMCKEGIMNGM----------------LTTTFCGTPDYIAPEIL------KEQEYGA-SVDWWALGV-LMYEMMA-GQPPFEA-------DNEDELFDSIMHD-DV-LYPVW---------------------------------------LSREAVS-ILKGFLTKNPEQRLGCGDENE----IRKHPFF
AplII      FNFIKVLGKGSFGKVMLAEKKG--------------TDEVYAIKVLKKDVIIQDD----------DVECTMTEKRILALSA--------KHPFLTALHSSFQTK---------ERLFFVMEYVNG--GDLMFQIQRARK-----------------------------FDEPRARFYAAEVTLALMFLHRH---------------GIIYRDLKLDNILLDAEG---------HCKIADFGMCKEGMTENK----------------LTQTFCGTPDYIAPEIL------QELKYDA-SVDWWALGV-LMYEMMA-GQPPFEA-------DNEDDLFESILHD-DV-LYPVW---------------------------------------LSKEAVS-ILKGFMTKNPAKRLGCVTTQGCEKAILVHPFF
CeTPA1     FNLLKVLGKGSFGKVMLVELKG--------------KNEFYAMKCLKKDVILEDD----------DTECTYIERRVLILAS--------QCPFLCQLFCSFQTN---------EYLFFVMEYLNG--GDLMHHIQQIKK-----------------------------FDEARTRFYACEIVVALQFLHTN---------------NIIYRDLKLDNVLLDCDG---------HIKLADFGMAKTEMNRENG---------------MASTFCGTPDYISPEII------KGQLYNE-AVDFWSFGV-LMYEMLV-GQSPFHG-------EGEDELFDSILNE-RP-YFPKT---------------------------------------ISKEAAK-CLSALFDRNPNTRLGMPECPDGP--IRQHCFF
CePKC1B    FTFMKVLGKGSFGKVMLAERKG--------------TDEVYAIKILKKDVIVQDD----------DVECTMCEKRILSLAA--------KHPFLTALHSSFQTS---------DRLFFVMEYVNG--GDLMFQIQRARK-----------------------------FDESRARFYAAEVTCALQFLHRN---------------DVIYRDLKLDNILLDAEG---------HCRLADFGMCKEGINKDN----------------LTSTFCGTPDYTAPEIL------QEMEYGV-SVDWWALGV-LMYEMMA-GQPPFEA-------DNEDDLFEAILND-DV-LYPVW---------------------------------------LSKEAVN-ILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
PKC1       FVLLKVLGKGNFGKVILSKSKN--------------TDRLCAIKVLKKDNIIQNH----------DIESARAEKKVFLLATKT------KHPFLTNLYCSFQTE---------NRIYFAMEFIGG--GDLMWHVQNQR------------------------------LSVRRAKFYAAEVLLALKYFHDN---------------GVIYRDLKLENILLTPEG---------HIKIADYGLCKDEMWYGN----------------RTSTFCGTPEFMAPEIL------KEQEYTK-AVDWWAFGV-LLYQMLL-CQSPFSG-------DDEDEVFNAILTD-EP-LYPID---------------------------------------MAGEIVQ-IFQGLLTKDPEKRLGAGPRDADE--VMEEPFF
pck1+      FTFLAVLGKGNFGKVMLAEYKV--------------NKKFYAIKVLKKEAILKNE----------ELESLKTEKHVFEVANKE------KHPFLLNLFASFQTS---------TRVYFVMEYILG--GDLMVHIQRQQ------------------------------FSVKRARFYGAEVCLALKYFHEN---------------GIAYRDLKLDNILLCPDG---------HIRIADYGLCKENMLLGN----------------TTSTFCGTPEFMAPEIL------LEQQYSK-DVDWWAFGV-LMYQMLL-GQSPFKG-------EDEEEIFDAILSD-EP-LFPIN---------------------------------------MPADAVS-LLRGLLTRDPNQRLGSGPKDANE--VMAHPFF
pck2+      FTFLSVLGKGNFGKVMLAELKS--------------EKQLYAIKVLKKEFILEND----------EVESTKSEKRVFLVANRE------RHPFLVNLHSCFQTE---------TRIYFVMDFVSG--GDLMLHIQQEQ------------------------------FSRRRAQFYAAEVCLALKYFHDN---------------GIIYRDLKLDNILLSPDG---------HVKVADYGLCKEDMWHDN----------------TTATFCGTPEFMAPEIL------LEQQYTR-SVDWWAFGV-LIYQMLL-GQSPFRG-------EDEEEIFDAILSD-EP-LYPIH---------------------------------------MPRDSVS-ILQQLLTRDPKKRLGSGPNDAED--VMTHPFF

PKCz       FDLIRVIGRGSYAKVLLVRLKK--------------NDQIYAMKVVKKELVHDDE----------DIDWVQTEKHVFEQAS--------SNPFLVGLHSCFQTT---------SRLFLVIEYVNG--GDLMFHMQRQRK-----------------------------LPEEHARFYAAEICIALNFLHER---------------GIIYRDLKLDNVLLDADG---------HIKLTDYGMCKEGLGPGD----------------TTSTFCGTPNYIAPEIL------RGEEYGF-SVDWWALGV-LMFEMMA-GRSPFDIITDN{3}NTEDYLFQVILEK-PI-RIPRF---------------------------------------LSVKASH-VLKGFLNKDPKERLGC-PQTGFSD-IKSHAFF
PKCi       FDLLRVIGRGSYAKVLLVRLKK--------------TDRIYAMKVVKKELVNDDE----------DIDWVQTEKHVFEQAS--------NHPFLVGLHSCFQTE---------SRLFFVIEYVNG--GDLMFHMQRQRK-----------------------------LPEEHARFYSAEISLALNYLHER---------------GIIYRDLKLDNVLLDSEG---------HIKLTDYGMCKEGLRPGD----------------TTSTFCGTPNYIAPEIL------RGEDYGF-SVDWWALGV-LMFEMMA-GRSPFDIVGSS{5}NTEDYLFQVILEK-QI-RIPRS---------------------------------------LSVKAAS-VLKSFLNKDPKERLGCHPQTGFAD-IQGHPFF
PKCm       IFPDEVLGSGQFGIVYGGKHRK--------------TGRDVAIKIIDKLRFPTK-----------QESQLRNEVAILQNL---------HHPGVVNLECMFETP---------ERVFVVMEKLHG--DMLEMILSSEKGR----------------------------LPEHITKFLITQILVALRHLHFK---------------NIVHCDLKPENVLLASADPFP------QVKLCDFGFARIIGEKS-----------------FRRSVVGTPAYLAPEVL------RNKGYNR-SLDMWSVGV-IIYVSLS-GTFPFN--------EDED-IHDQIQNA-AF-MYPPNPWKE-----------------------------------ISHEAID-LINNLLQVKMRKRYSVDKTLS-------HPWL


AGC Group III

RAC(Akt) protein kinase family

Akt1/Raca  FEYLKLLGKGTFGKVILVKEKA--------------TGRYYAMKILKKEVIVAKD----------EVAHTLTENRVLQNS---------RHPFLTALKYSFQTH---------DRLCFVMEYANG--GELFFHLSRERV-----------------------------FSEDRARFYGAEIVSALDYLHSEK--------------NVVYRDLKLENLMLDKDG---------HIKITDFGLCKEGIKDGA----------------TMKTFCGTPEYLAPEVL------EDNDYGR-AVDWWGLGV-VMYEMMC-GRLPFYN-------QDHEKLFELILME-EI-RFPRT---------------------------------------LGPEAKS-LLSGLLKKDPTQRLGGGSEDAKE--IMQHRFF
Akt2/Racb  FDYLKLLGKGTFGKVILVREKA--------------TGRYYAMKILRKEVIIAKD----------EVAHTVTESRVLQNT---------RHPFLTALKYAFQTH---------DRLCFVMEYANG--GELFFHLSRERV-----------------------------FTEERARFYGAEIVSALEYLHSR---------------DVVYRDIKLENLMLDKDG---------HIKITDFGLCKEGISDGA----------------TMKTFCGTPEYLAPEVL------EDNDYGR-AVDWWGLGV-VMYEMMC-GRLPFYN-------QDHERLFELILME-EI-RFPRT---------------------------------------LSPEAKS-LLAGLLKKDPKQRLGGGPSDAKE--VMEHRFF
DmRAC      FEFLKVLGKGTFGKVILCREKA--------------TAKLYAIKILKKEVIIQKD----------EVAHTLTESRVLKST---------NHPFLISLKYSFQTN---------DRLCFVMQYVNG--GELFWHLSHERI-----------------------------FTEDRTRFYGAEIISALGYLHSQ---------------GIIYRDLKLENLLLDKDG---------HIKVADFGLCKEDITYGR----------------TTKTFCGTPEYLAPEVL------DDNDYGQ-AVDWWGTGV-VMYEMIC-GRLPFYN-------RDHDVLFTLILVE-EV-KFPRN---------------------------------------ITDEAKN-LLAGLLAKDPKKRLGGGKDDVKE--IQAHPFF


AGC Group IV

Kinases that phoshorylate G protein-coupled receptors family

bARK1      FSVHRIIGRGGFGEVYGCRKAD--------------TGKMYAMKCLDKKRIKMKQ----------GETLALNERIMLSLVSTG------DCPFIVCMSYAFHTP---------DKLSFILDLMNG--GDLHYHLSQHGV-----------------------------FSEADMRFYAAEIILGLEHMHNR---------------FVVYRDLKPANILLDEHG---------HVRISDLGLACDFSKK------------------KPHASVGTHGYMAPEVLQ-----KGVAYDS-SADWFSLGC-MLFKLLR-GHSPFRQHK-----TKDKHEIDRMTLTMAV-ELPDS---------------------------------------FSPELRS-LLEGLLQRDVNRRLGCLGRGAQE--VKESPFF
bARK2      FSVHRIIGRGGFGEVYGCRKAD--------------TGKMYAMKCLDKKRIKMKQ----------GETLALNERIMLSLVSTG------DCPFIVCMTYAFHTP---------DKLCFILDLMNG--GDLHYHLSQHGV-----------------------------FSEKEMRFYATEIILGLEHVHNR---------------FVVYRDLKPANILLDEHG---------HARISDLGLACDFSKK------------------KPHASVGTHGYMAPEVLQ-----KGTAYDS-SADWFSLGC-MLFKLLR-GHSPFRQHK-----TKDKHEIDRMTLTVNV-ELPDT---------------------------------------FSPELKS-LLEGLLQRDVSKRLGCHGGGSQE--VKEHSFF
RhoK       FLDFRVLGRGGFGEVFACQMKA--------------TGKLYACKKLNKKRLKKRK----------GYQGAMVEKKILAKV---------HSRFIVSLAYAFETK---------TDLCLVMTIMNG--GDIRYHIYNVDEDNPG-------------------------FQEPRAIFYTAQIVSGLEHLHQR---------------NIIYRDLKPENVLLDDDG---------NVRISDLGLAVELKAGQT----------------KTKGYAGTPGFMAPELLL------GEEYDF-SVDYFALGV-TLYEMIA-ARGPFRARGE----KVENKELKQRVLEQAV-TYPDK---------------------------------------FSPASKD-FCEALLQKDPEKRLGFRDGSCDG--LRTHPLF
GRK5       FRQYRVLGKGGFGEVCACQVRA--------------TGKMYACKRLEKKRIKKRK----------GESMALNEKQILEKV---------NSQFVVNLAYAYETK---------DALCLVLTIMNG--GDLKFHIYNMGNPG---------------------------FEEERALFYAAEILCGLEDLHRE---------------NTVYRDLKPENILLDDYG---------HIRISDLGLAVKIPEGD-----------------LIRGRVGTVGYMAPEVLN------NQRYGL-SPDYWGLGC-LIYEMIE-GQSPFRGRKE----KVKREEVDRRVLETEE-VYSHK---------------------------------------FSEEAKS-ICKMLLTKDAKQRLGCQEEGAAE--VKRHPFF
IT11       FRHYRVLGKGGFGEVCACQVRA--------------TGKMYACKKLQKKRIKKRK----------GEAMALNEKRILEKV---------QSRFVVSLAYAYETK---------DALCLVLTIMNG--GDLKFHIYNLGNPG---------------------------FDEQRAVFYAAELCCGLEDLQRE---------------RIVYRDLKPENILLDDRG---------HIRISDLGLATEIPEGQ-----------------RVRGRVGTVGYMAPEVVN------NEKYTF-SPDWWGLGC-LIYEMIQ-GHSPFKKYKE----KVKWEEVDQRIKNDTE-EYSEK---------------------------------------FSEDAKS-ICRMLLTKNPSKRLGCRGEGAAG--VKQHPVF
GRK6       FRQYRVLGKGGFGEVCACQVRA--------------TGKMYACKKLEKKRIKKRK----------GEAMALNEKQILEKV---------NSRFVVSLAYAYETK---------DALCLVLTLMNG--GDLKFHIYHMGQAG---------------------------FPEARAVFYAAEICCGLEDLHRE---------------RIVYRDLKPENILLDDHG---------HIRISDLGLAVHVPEGQ-----------------TIKGRVGTVGYMAPEVVK------NERYTF-SPDWWALGC-LLYEMIA-GQSPFQQRKK----KIKREEVERLVKEVPE-EYSER---------------------------------------FSPQARS-LCSQLLCKDPAERLGCRGGSARE--VKEHPLF
DmGPRK1    FSVHRIIGRGGFGEVYGCRKAD--------------TGKMYAMKCLDKKRIKMKQ----------GEMLALNERNMLQAVSTGI-----DCPFIVCMTYAFHTP---------DKLCFILDLMNG--GDLHYHLSQHGI-----------------------------FSEDEMKFYAAEVILGLEHMHKR---------------CIVYRDLKPANILLDENG---------HIRISDLGLACDFSKK------------------KPHASVGTHGYMAPEVLS-----KGTSYDS-CADWFSFGC-MLYKLLK-GHSPFRQHK-----TKDKLEIDKMTLTMNV-ELPES---------------------------------------FSLELKN-LLEMLLQRDVSKRLGCMGNGADE--VKMHNFF
DmGPRK2    FRMYRVLGKGGFGEVCACQVRA--------------TGKMYACKKLEKKRIKKRK----------GESMVLIEKQILQKI---------NSPFVVNLAYAYETK---------DALCLVLTIMNG--GDLKFHIYNMGGEPG--------------------------FELERARFYAAEVACGLQHLHKQ---------------GIVYRDCKPENILLDDHG---------HVRISDLGLAVEIPEGE-----------------MVRGRVGTVGYMAPEVI------DNEKYAF-SPDWFSFGC-LLYEMIE-GQAPFRMRKE----KVKREEVDRRVKEDPE-KYSSK---------------------------------------FNDEAKS-MCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFF


AGC Group V

Budding yeast AGC-related protein kinase family

SCH9       FEVLRLLGKGTFGQVYQVKKKD--------------TQRIYAMKVLSKKVIVKKN----------EIAHTIGERNILVTTASK------SSPFIVGLKFSFQTP---------TDLYLVTDYMSG--GELFWHLQKEGR-----------------------------FSEDRAKFYIAELVLALEHLHDN---------------DIVYRDLKPENILLDANG---------NIALCDFGLSKADLKDKD----------------RTNTFCGTTEYLAPELLL-----DETGYTK-MVDFWSLGV-LIFEMCC-GWSPFFA-------ENNQKMYQKIAFGKV--KFPRDV--------------------------------------LSQEGRS-FVKGLLNRNPKHRLGAIDDG-RE--LRAHPFF
YPK1       FDLLKVIGKGSFGKVMQVRKKD--------------TQKVYALKAIRKSYIVSKS----------EVTHTLAERTVLARV---------DCPFIVPLKFSFQSP---------EKLYFVLAFING--GELFYHLQKEGR-----------------------------FDLSRARFYTAELLLALDNLHKL---------------DVVYRDLKPENILLDYQG---------HIALCDFGLCKLNMKDDD----------------KTDTFCGTPEYLAPELL------LGLGYTK-AVDWWTLGV-LLYEMLT-GLPPYYR-------EDVPKIYKKILQEPL--VFPDG---------------------------------------FDRDAKD-LLIGLLSRDPTRRLGYN-GA-DE--IRNHPFF
YKR2       FDLLKVIGKGSFGKVMQVRKKD--------------TQKIYALKALRKAYIVSKC----------EVTHTLAERTVLARV---------DCPFIVPLKFSFQSP---------EKLYLVLAFING--GELFYHLQHEGR-----------------------------FSLARSRFYIAELLCALDSLHKL---------------DVIYRDLKPENILLDYQG---------HIALCDFGLCKLNMKDND----------------KTDTFCGTPEYLAPEIL------LGQGYTK-TVDWWTLGI-LLYEMMT-GLPPYYD-------ENVPVMYKKILQQPL--LFPDG---------------------------------------FDPAAKD-LLIGLLSRDPSRRLGVN-GT-DE--IRNHPFF


AGC Group VI

Kinases that phosphorylate ribosomal protein S6 family

S6K        FELLRVLGKGGYGKVFQVRKVTGAN-----------TGKIFAMKVLKKAMIVRNAK---------DTAHTKAERNILEEV---------KHPFIVDLIYAFQTG---------GKLYLILEYLSG--GELFMQLEREGI-----------------------------FMEDTACFYLAEISMALGHLHQK---------------GIIYRDLKPENIMLNHQG---------HVKLTDFGLCKESIHDGT----------------VTHTFCGTIEYMAPEIL------MRSGHNR-AVDWWSLGA-LMYDMLT-GAPPFTG-------ENRKKTIDKILKCKL--NLPPY---------------------------------------LTQEARD-LLKKLLKRNAASRLGAGPGDAGE--VQAHPFF
RSK1N      FELLKVLGQGSFGKVFLVRKVTRPD-----------NGHLYAMKVLKKATLKVR-----------DRVRTKMERDILADV---------NHPFVVKLHYAFQTE---------GKLYLILDFLRG--GDLFTRLSKEVM-----------------------------FTEEDVKFYLAELALGLDHLHSL---------------GIIYRDLKPENILLDEEG---------HIKLTDFGLSKEAIDHEK----------------KAYSFCGTVEYMAPEVV------NRQGHTH-SADWWSYGV-LMFEMLT-GSLPFQG-------KDRKETMTLILKAKL--GMPQF---------------------------------------LSTEAQS-LLRALFKRNPANRLGSGPDGAEE--IKRHIFY
RSK2N      FELLKVLGQGSFGKVFLVKKISGSD-----------ARQLYAMKVLKKATLKVR-----------DRVRTKMERDILVEV---------NHPFIVKLHYAFQTE---------GKLYLILDFLRG--GDLFTRLSKEVM-----------------------------FTEEDVKFYLAELALALDHLHSL---------------GIIYRDLKPENILLDEEG---------HIKLTDFGLSKESIDHEK----------------KAYSFCGTVEYMAPEVV------NRRGHTQ-SADWWSFGV-LMFEMLT-GTLPFQG-------KDRKETMTMILKAKL--GMPQF---------------------------------------LSPEAQS-LLRMLFKRNPANRLGAGPDGVEE--IKRHSFF


AGC Group VII

Budding yeast DBF2/20 family

DBF2       FEMITQVGQGGYGQVYLARKKD--------------TKEVCALKILNKKLLFKLN----------ETKHVLTERDILTTT---------RSEWLVKLLYAFQEL---------QSLYLAMEFVPG--GDFRTLLINTRC-----------------------------LKSGHARFYISEMFCAVNALHDL---------------GYTHRDLKPENFLIDAKG---------HIKLTDFGLAAGTISNERIESMKIRLEKIK{29}YANSMVGSPDYMALEVL------EGKKYDF-TVDYWSLGC-MLFESLV-GYTPFSG-------SSTNETYDNLRRWKQTLRRPRQSDGRAA---------------------------------FSDRTWD-LITRLIA-DPINRLRSF----EH--VKRMSYF
DBF20      FQILTQVGQGGYGQVYLAKKKD--------------SDEICALKILNKKLLFKLN----------ETNHVLTERDILTTT---------RSDWLVKLLYAFQDP---------ESLYLAMEFVPG--GDFRTLLINTRI-----------------------------LKSGHARFYISEMFCAVNALHEL---------------GYTHRDLKPENFLIDATG---------HIKLTDFGLAAGTVSNERIESMKIRLEEVK{28}YANSMVGSPDYMALEVL------EGKKYDF-TVDYWSLGC-MLFESLV-GYTPFSG-------SSTNETYENLRYWKKTLRRPRTEDRRAA---------------------------------FSDRTWD-LITRLIA-DPINRVRSF----EQ--VRKMSYF


AGC Group VIII

Flowering plant PVPK1 protein kinase homolog family

PVPK1      FRLLKKLGCGDIGSVYLAELSG--------------TRTSFAMKVMNKTELANRK----------KLLRAQTEREILQSL---------DHPFLPTLYTHFETE---------IFSCLVMEFCPG--GDLHALRQRQPGKY---------------------------FSEHAVRFYVAEVLLSLEYLHML---------------GIIYRDLKPENVLVREDG---------HIMLSDFDLSLRCSVSPTLVKSSNNLQTKS{64}RSMSFVGTHEYLAPEII------KGEGHGS-AVDWWTFGI-FLYELLF-GRTPFKG-------ANRATLFNVIGQPLR---FPESPT-------------------------------------VSFAARD-LIRGLLVKEPQHRLAYRRGAT-E--IKQHPFF
G11A       FKLLKKLGCGDIGSVYLSELSG--------------TESYFAMKVMDKASLASRK----------KLLRAQTEKEILQCL---------DHPFLPTLYTHFETD---------KFSCLVMEFCPG--GDLHTLRQRQRGKY---------------------------FPEQAVKFYVAEILLAMEYLHML---------------GIIYRDLKPENVLVREDG---------HIMLSDFDLSLRCAVSPTLIRSSNPDAEAL{66}RSMSFVGTHEYLAPEII------KGEGHGS-AVDWWTFGI-FLYELLF-GKTPFKGS------GNRATLFNVIGQPLR---FPEYPV-------------------------------------VSFSARD-LIRGLLVKEPQQRLGCKRGAT-E--IKQHPFF
ZmPPK      FRLLKRLGCGDIGSVYLSELSG--------------TKCYFAMKIMDKASLASRK----------KLLRAQTEREILQCL---------DHPFLPTLYTHFETD---------KFSCLVMEFCPG--GDLHTLRQKQPGKY---------------------------FPEQAAKFYVAEVLLALEYLHML---------------GIIYRDLKPENVLVREDG---------HIMLSDFDLSLRCAVSPTLLRSSNPSGDNQ{67}KSMSFVGTHEYLAPEII------KGEGHGS-AVDWWTFGI-FLYELLF-GKTPFKGS------GNRATLFNVVGQPLR---FPESPV-------------------------------------VSFAARD-LIRGLLIKEPQHRLAYKRGAT-E--IKQHPFF
ATPK5      FRLLKRLGCGDIGSVYLSELSG--------------TKCYFAMKVMDKTSLASRK----------KLLRAQTEREILQSL---------DHPFLPTLYTHFETE---------KFSCLVMEFCPG--GDLHTLRQRQPGKH---------------------------FSEQAVKFYIAESLLALEYLHML---------------GIVYRDLKPENVLVREDG---------HIMLSDFDLSLRCLVSPTLVKSAAIESDPL{67}RSMSFVGTHEYLAPEII------KGEGHGS-AVDWWTFGI-FLYELLF-GRTPFKGS------GNRQTLFNVVGQPLR---FPETPV-------------------------------------VSFAARD-LIRGLLMKEPQQRLGFKRGAT-E--VKQHPFF
ATPK7      FKLIKKLGGGDIGNVYLAELIG--------------TGVSFAVKVMEKAAIAARK----------KLVRAQTEKEILQSL---------DHPFLPTLYSHFETE---------MNSCLVMEFCPG--GDLHSLRQKQRGKY---------------------------FPEQAARFYVAEVLLAMEYLHML---------------GIIYRDLKPENVLVREDG---------HIMLSDFDLSLRCAVSPTLVRFAAITLESK{62}RSMSFVGTHEYLAPEII------KGEGHGS-AVDWWTFGI-FLYELLF-GITPFRGG------DNRATLFNVVGQPLR---FPEHPN-------------------------------------VSFAARD-LIRGLLVKEPQHRLAYRRGAT-E--IKQHPFF
ATPK64     FRLLKRLGCGDIGTVHLAELNG--------------TRCYFAMKVMDKTALASRK----------KLLRAQTEREILQCL---------DHPFLPTLYSHFETE---------KFSCLVMEFCPG--GDLHTLRQRQPGKR---------------------------FTEQAAKFYVAEVLLAMEYLHML---------------GIIYRDLKPENVLVRDDR---------HVMLSDFDLSLRCTVSLSIVRSANVGSEGL{65}RSMSFVGTHEYLAPEII------KGEGHGS-AVDWWTFGI-FLYELLF-GKTPFKGS------GNRATLFNVVGQPLR---FPESPV-------------------------------------VSFAARD-LIRSLLVKEPQHRLAYKRGAT-E--IKQHPFF
PsPK5      FKPIKPLGSGDTGSVHLVELCG--------------TDHQFAMKAMDKGVILNRN----------KEHRACTEREILDML---------DHPFLPALYASFQTK---------THICLITDYCPG--GELFMLLDRQPAKV---------------------------LKEDAVRFYATEVVVALEYLHCQ---------------GIIYRDLKPENVLLQSTG---------HVSLTDFDLSCLTSCKPQLLVPSTNDKKKG{12}ASNSFVGTEEYIAPEII------TGSGHTS-AVDWWALGI-LLYEMFY-GYTPFRG-------KNRQRTFANILHKDLK--FPKSKQ-------------------------------------VSLGAKQ-LIYYLLQRDPTSRLGSKGGAN-D--IKNHSFF


AGC Group Other

DM         FEILKVIGRGAFSEVAVVKMKQ--------------TGQVYAMKIMNKWDMLKRG----------EVSCFREERDVLVNG---------DRRWITQLHFAFQDE---------NYLYLVMEYYVG--GDLLTLLSKFGER----------------------------IPAEMARFYLAEIVMAIDSVHRL---------------GYVHRDIKPDNILLDRCG---------HIRLADFGSCLKLRADGTV---------------RSLVAVGTPDYLSPEILQAV{4}GTGSYGP-ECDWWALGV-FAYEMFY-GQTPFYA-------DSTAETYGKIVHYKEHLSLPLVDEG------------------------------------VPEEARD-FIQRLLC-PPETRLGRG-GA-GD--FRTHPFF
Sgk        FHFLKVIGKGSFGKVLLARHKA--------------EEAFYAVKVLQKKAILKKK----------EEKHIMSERNVLLKNV--------KHPFLVGLHFSFQTA---------DKLYFVLDYING--GELFYHLQRERC-----------------------------FLEPRARFYAAEIASALGYLHSL---------------NIVYRDLKPENILLDSQG---------HIVLTDFGLCKENIEHNG----------------TTSTFCGTPEYLAPEVL------HKQPYDR-TVDWWCLGA-VLYEMLY-GLPPFYS-------RNTAEMYDNILNK-PL-QLKN----------------------------------------ITNSARH-LLEGLLQKDRTKRLGAKDDFM-E--IKSHIFF
Mast205    FETIKLISNGAYGAVFLVRHKS--------------TRQRFAMKKINKQNLILRN----------QIQQAFVERDILTFA---------ENPFVVSMFCSFETK---------RHLCMVMEYVEG--GDCATLLKNIGA-----------------------------LPVDMVRLYFAETVLALEYLHNY---------------GIVHRDLKPDNLLITSMG---------HIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREF-LDKQVCGTPEYIAPEVI------LRQGYGK-PVDWWAMGI-ILYEFLV-GCVPFFG-------DTPEELFGQVISD-EI-VWPEGDDA------------------------------------LPPDAQD-LTSKLLHQNPLERLGTSSAY--E--VKQHPFF
cot-1      YQTIKIIGKGAFGEVKLVQKKA--------------DGKVYAMKSLIKTEMFKKD----------QLAHVRAERDILAES---------DSPWVVKLYTTFQDA---------NFLYMLMEFLPG--GDLMTMLIKYEI-----------------------------FSEDITRFYIAEIVLAIDAVHKL---------------GFIHRDIKPDNILLDRGG---------HVKLTDFGLSTGFHKLHDNNYYTQLLQGKS{34}MAYSTVGTPDYIAPEIF------TGHGYSF-DCDWWSLGT-IMFECLV-GWPPFCA-------EDSHDTYRKIVNWRHSLYFPDDIT-------------------------------------LGVDAEN-LIRSLIC-NTENRLGRG-GA-HE--IKSHAFF
DdK2       FELLNVIGKGSFGKVMQVKKKG--------------EDKIFAMKVLRKDAIIARK----------QVNHTKSEKTILQCI---------SHPFIVNLHYAFQTK---------DKLYMVLDFVNG--GELFFHLKREGR-----------------------------FSEPRVKIYAAEIVSALDHLHKQ---------------DIVYRDLKPENILLDSEG---------HICITDFGLSKKIETTD-----------------GTFTFCGTPEYLAPEVL------NGHGHGC-AVDWWSLGT-LLYEMLT-GLPPFYS-------ENVSTMYQKILNGEL--KIPTY---------------------------------------ISPEAKS-LLEGLLTREVDKRLGTK-GG-GE--VKQHPWF
SPK1       SIIDEVVGQGAFATVKKAIERT--------------TGKTFAVKIISKRKVIG------------NMDGVTRELEVLQKL---------NHPRIVRLKGFYEDT---------ESYYMVMEFVSG--GDLMDFVAAHGA-----------------------------VGEDAGREISRQILTAIKYIHSM---------------GISHRDLKPDNILIEQDDPV-------LVKITDFGLAKVQGNGS-----------------FMKTFCGTLAYVAPEVIRG{11}ERNEYSS-LVDMWSMGC-LVYVILT-GHLPFSG-------STQDQLYKQIGRGSYHEGPLKDFR-------------------------------------ISEEARD-FIDSLLQVDPNNRSTAAKALN-------HPWI

CaMK Group I

[Current Alignment (10-97) with Viewer]

Kinases regulated by Ca2+/CaM and close relatives family


CaMKIIa    YQLFEELGKGAFSVVRRCVKVL--------------AGQEYAAKIINTKKLSAR-----------DHQKLEREARICRLL---------KHPNIVRLHDSISEE---------GHHYLIFDLVTG--GELFEDIVAREY-----------------------------YSEADASHCIQQILEAVLHCHQM---------------GVVHRDLKPENLLLASKLKGA------AVKLADFGLAIEVEGEQQ----------------AWFGFAGTPGYLSPEVL------RKDPYGK-PVDLWACGV-ILYILLV-GYPPFWD-------EDQHRLYQQIKAGAYDFPSPEWDT-------------------------------------VTPEAKD-LINKMLTINPSKRITAAEALK-------HPWI
CaMKIIb    YQLYEDIGKGAFSVVRRCVKLC--------------TGHEYAAKIINTKKLSAR-----------DHQKLEREARICRLL---------KHSNIVRLHDSISEE---------GFHYLVFDLVTG--GELFEDIVAREY-----------------------------YSEADASHCIQQILEAVLHCHQM---------------GVVHRDLKPENLLLASKCKGA------AVKLADFGLAIEVQGDQQ----------------AWFGFAGTPGYLSPEVL------RKEAYGK-PVDIWACGV-ILYILLV-GYPPFWD-------EDQHKLYQQIKAGAYDFPSPEWDT-------------------------------------VTPEAKN-LINQMLTINPAKRITAHEALK-------HPWV
CaMKIIg    YQLFEELGKGAFSVVRRCVKKT--------------STQEYAAKIINTKKLSAR-----------DHQKLEREARICRLL---------KHPNIVRLHDSISEE---------GFHYLVFDLVTG--GELFEDIVAREY-----------------------------YSEADASHCIHQILESVNHIHQH---------------DIVHRDLKPENLLLASKCKGA------AVKLADFGLAIEVQGEQQ----------------AWFGFAGTPGYLSPEVL------RKDPYGK-PVDIWACGV-ILYILLV-GYPPFWD-------EDQHKLYQQIKAGAYDFPSPEWDT-------------------------------------VTPEAKN-LINQMLTINPAKRITADQALK-------HPWV
CaMKIId    YQLFEELGKGAFSVVRRCMKIP--------------TGQEYAAKIINTKKLSAR-----------DHQKLEREARICRLL---------KHPNIVRLHDSISEE---------GFHYLVFDLVTG--GELFEDIVAREY-----------------------------YSEADASHCIQQILESVNHCHLN---------------GIVHRDLKPENLLLASKSKGA------AVKLADFGLAIEVQGDQQ----------------AWFGFAGTPGYLSPEVL------RKDPYGK-PVDMWACGV-ILYILLV-GYPPFWD-------EDQHRLYQQIKAGAYDFPSPEWDT-------------------------------------VTPEAKD-LINKMLTINPAKRITASEALK-------HPWI
DmCamKII   YDIKEELGKGAFSIVKRCVQKS--------------TGFEFAAKIINTKKLTAR-----------DFQKLEREARICRKL---------HHPNIVRLHDSIQEE---------NYHYLVFDLVTG--GELFEDIVAREF-----------------------------YSEADASHCIQQILESVNHCHQN---------------GVVHRDLKPENLLLASKAKGA------AVKLADFGLAIEVQGDHQ----------------AWFGFAGTPGYLSPEVL------KKEPYGK-SVDIWACGV-ILYILLV-GYPPFWD-------EDQHRLYSQIKAGAYDYPSPEWDT-------------------------------------VTPEAKN-LINQMLTVNPNKRITAAEALK-------HPWI

CamKI      YDFRDVLGTGAFSEVILAEDKR--------------TQKLVAIKCIAKKALEG------------KEGSMENEIAVLHKI---------KHPNIVALDDIYESG---------GHLYLIMQLVSG--GELFDRIVEKGG-----------------------------YTERDRSRLIFQVLDAVKYLHDL---------------GIVHRDLKPENLLYYSLDEDS------KIMISDFGLSKMEDPGS-----------------VLSTACGTPGYVAPEVL------AQKPYSK-AVDCWSIGV-IAYILLC-GYPPFYD-------ENDAKLFEQILKAEYEFDSPYWDD-------------------------------------ISDSAKD-FIRHLMEKDPEKRFTCEQALQ-------HPWI
CaMKIV     FEVESELGRGATSIVYRCKQKG--------------TQKPYALKVLKKTV---------------DKKIVRTEIGVLLRL---------SHPNIIKLKEIFETP---------TEISLVLELVTG--GELFDRIVEKGY-----------------------------YSERDAADAVKQILEAVAYLHEN---------------GIVHRDLKPENLLYATPAPEA------PLKIADFGLSKIVEHQV-----------------LMKTVCGTPGYCAPEIL------RGCAYGP-EVDMWSVGI-ITYILLC-GFEPFYDE------RGDQFMFRRILNCEYYFISPWWDE-------------------------------------VSLNAKD-LVKKLIVLDPKKRLTTFQALQ-------HPWV
DdMLCK     YEFKEELGRGAFSIVYLGENKQ--------------TKQRYAIKVINKSELGKD-----------YEKNLKMEVDILKKV---------NHPNIIALKELFDTP---------EKLYLVMELVTG--GELFDKIVEKGS-----------------------------YSEADAANLVKKIVSAVGYLHGL---------------NIVHRDLKPENLLLKSKENHL------EVAIADFGLSKIIGQTL-----------------VMQTACGTPSYVAPEVL------NATGYDK-EVDMWSIGV-ITYILLC-GFPPFYG-------DTVPEIFEQIMEVNYEFPEEYWGG-------------------------------------ISKEAKD-FIGKLLVVDVSKRLNATNALN-------HPWL
DUN1       YLLGKELGAGHYALVKEAKNKK--------------TGQQVAVKIFHAQQNDDQK----------KNKQFREETNILMRV---------QHPNIVNLLDSFVEPISKSQ----IQKYLVLEKIDD--GELFERIVRKTC-----------------------------LRQDESKALFKQLLTGLKYLHEQ---------------NIIHRDIKPENILLNITRRENPS{14}QVKIADFGLAKFTGEMQ-----------------FTNTLCGTPSYVAPEVL------TKKGYTS-KVDLWSAGV-ILYVCLC-GFPPFSDQ------LGPPSLKEQILQAKYAFYSPYWDK-------------------------------------IDDSVLH-LISNLLVLNPDERYNIDEALN-------HPWF
PSK-H1     YDIKALIGRGSFSRVVRVEHRA--------------TRQPYAIKMIETKYRE-------------GREVCESELRVLRRV---------RHANIIQLVEVFETQ---------ERVYMVMELATG--GELFDRIIAKGS-----------------------------FTERDATRVLQMVLDGVRYLHAL---------------GITHRDLKPENLLYYHPGTDS------KIIITDFGLASARKKGDDC---------------LMKTTCGTPEYIAPEVL------VRKPYTN-SVDMWALGV-IAYILLS-GTMPFED-------DNRTRLYRQILRGKYSYSGEPWPS-------------------------------------VSNLAKD-FIDRLLTVDPGARMTALQALR-------HPWV

CMKI       YVFGKTLGAGTFGVVRVRKNTE--------------TGEDVAVKILIKKALKGNKV---------QLEALYDELDILQRL---------HHPNIVAFKDWFESK---------DKFYIITQLAKG--GELFDRILKKGK-----------------------------FTEEDAVRILVEILSAVKYMHSQ---------------NIVHRDLKPENLLTIDKSDES------PLVVADFGIAKRLKSDEE----------------LLYKAGTALGYVAPEVL------TQDGHGK-PCDIWSIGV-ITYTLLC-GYATIDRK------VQDFLDECTTGEYPVKFHRPYWDS-------------------------------------VSNQAKQ-FILKALNLDPSKRPTAAELLE-------DPWI
CMK2       YIFGRTLGAGSFGVVRQARKLS--------------TNEDVAIKILLKKALQGNNV---------QLQMLYEELSILQKL---------SHPNIVSFKDWFESK---------DKFYIVTQLATG--GELFDRILSRGK-----------------------------FTEVDAVEIIVQILGAVEYMHSK---------------NVVHRDLKPENVLYVDKSENS------PLVIADFGIAKQLKGEED----------------LIYKAAGSLGYVAPEVL------TQDGHGK-PCDIWSIGV-ITYTLLC-GYSPFIAES-----VEGFMEECTASRYPVTFHMPYWDN-------------------------------------ISIDAKR-FILKALRLNPADRPTATELLD-------DPWI
ACMPK      YRFGRTLGAGTYGIVREADC----------------SSGKVAVKIILKRNVRG------------NERMVYDELDLLQKL---------NHPHIVHFVDWFESK---------DKFYIVTQLATG--GELFDRICEYGK-----------------------------FTEKDASQTIRQVLDAVNYLHQR---------------NIVHRDLKPENLLYLTRDLDS------QLVLADFGIAKMLDNPAE----------------VLTSMAGSFGYAAPEVM------LKQGHGK-AVDIWSLGV-ITYTLLC-GYSPFRSEN-----LTDLIEECRSGR--VVFHERYWKD-------------------------------------VSKDAKD-FILSLLQVDPAQRPTSEEALK-------HPWL

MLCK-K     MNSKEALGGGKFGAVCTCTEKS--------------TGLKLAAKVIKKQTPK-------------DKEMVMLEIEVMNQL---------NHRNLIQLYAAIETP---------HEIVLFMEYIEG--GELFERIVDEDYH----------------------------LTEVDTMVFVRQICDGILFMHKM---------------RVLHLDLKPENILCVNTTGH-------LVKIIDFGLARRYNPNE-----------------KLKVNFGTPEFLSPEVV------NYDQISD-KTDMWSLGV-ITYMLLS-GLSPFLG-------DDDTETLNNVLSGNWYFDEETFEA-------------------------------------VSDEAKD-FVSNLIVKEQGARMSAAQCLA-------HPWL
MLCK-M     YDIEERLGSGKFGQVFRLVEKK--------------TGKVWAGKFFKAYSAK-------------EKENIRQEIGIMNCL---------HHPKLVQCVDAFEEK---------ANIVMVLEIVSG--GELFERIIDEDFE----------------------------LTERECIKYMRQISEGVEYIHKQ---------------GIVHLDLKPENIMCVNKTGT-------RIKLIDFGLARRLENAG-----------------SLKVLFGTPEFVAPEVI------NYEPISY-ATDMWSIGV-ICYILVS-GLSPFMG-------DNDNETLANVTSATWDFDDEAFDE-------------------------------------ISDDAKD-FISNLLKKDMKNRLDCTQCLQ-------HPWL
Titen      YMIAEDLGRGEFGIVHRCVETS--------------SKKTYMAKFVKVKGT--------------DQVLVKKEISILNIA---------RHRNILHLHESFESM---------EELVMIFEFISG--LDIFERINTSAFE----------------------------LNEREIVSYVHQVCEALQFLHSH---------------NIGHFDIRPENIIYQTRRSS-------TIKIIEFGQARQLKPGD-----------------NFRLLFTAPEYYAPEVH------QHDVVST-ATDMWSLGT-LVYVLLS-GINPFLA-------ETNQQIIENIMNAEYTFDEEAFKE-------------------------------------ISIEAMD-FVDRLLVKERKSRMTASEALQ-------HPWL
TWITCH     YDIHEELGTGAFGVVHRVTERA--------------TGNNFAAKFVMTPHES-------------DKETVRKEIQTMSVL---------RHPTLVNLHDAFEDD---------NEMVMIYEFMSG--GELFEKVADEHNK----------------------------MSEDEAVEYMRQVCKGLCHMHEN---------------NYVHLDLKPENIMFTTKRSN-------ELKLIDFGLTAHLDPKQ-----------------SVKVTTGTAEFAAPEVA------EGKPVGY-YTDMWSVGV-LSYILLS-GLSPFGG-------ENDDETLRNVKSCDWNMDDSAFSG-------------------------------------ISEDGKD-FIRKLLLADPNTRMTIHQALE-------HPWL
MRE4       EITNRIVGNGTFGHVLITHNSKERDEDVCY------HPENYAVKIIKL-----------------KPNKFDKEARILLRL---------DHPNIIKVYHTFCDRN--------NHLYIFQDLIPG--GDLFSYLAKGDCLTS--------------------------MSETESLLIVFQILQALNYLHDQ---------------DIVHRDLKLDNILLCTPEPCT------RIVLADFGIAKDLNSNKE----------------RMHTVVGTPEYCAPEVGFR{15}EQRGYDS-KCDLWSLGV-ITHIMLT-GISPFYGD------GSERSIIQNAKIGKLNFKLKQWDI-------------------------------------VSDNAKS-FVKDLLQTDVVKRLNSKQGLK-------HIWI

PhKgM      YEPKEILGRGVSSVVRRCIHKP--------------TCKEYAVKIIDVTGGGSFSAEEVQE----LREATLKEVDILRKVS--------GHPNIIQLKDTYETN---------TFFFLVFDLMKK--GELFDYLTEKVT-----------------------------LSEKETRKIMRALLEVICALHKL---------------NIVHRDLKPENILLDDDM---------NIKLTDFGFSCQLDPGE-----------------KLREVCGTPSYLAPEIIECSMNDNHPGYGK-EVDMWSTGV-IMYTLLA-GSPPFWH-------RKQMLMLRMIMSGNYQFGSPEWDD-------------------------------------YSDTVKD-LVSRFLVVQPQKRYTAEEALA-------HPFF
PhKgT      YDPKDVIGRGVSSVVRRCVHRA--------------TGHEFAVKIMEVTAERLSPEQLEE-----VREATRRETHILRQVA--------GHPHIITLIDSYESS---------SFMFLVFDLMRK--GELFDYLTEKVA-----------------------------LSEKETRSIMRSLLEAVSFLHAN---------------NIVHRDLKPENILLDDNM---------QIRLSDFGFSCHLEPGE-----------------KLRELCGTPGYLAPEILKCSMDETHPGYGK-EVDLWACGV-ILFTLLA-GSPPFWH-------RRQILMLRMIMEGQYQFSSPEWDD-------------------------------------RSSTVKD-LISRLLQVDPEARLTAEQALQ-------HPFF
RSK1C      YVVKETIGVGSYSVCKRCVHKA--------------TNMEYAVKVIDK-----------------SKRDPSEEIEILLRYG--------QHPNIITLKDVYDDG---------KHVYLVTELMRG--GELLDKILRQF------------------------------FSEREASFVLHTISKTVEYLHSQ---------------GVVHRDLKPSNILYVDESGNPE-----CLRICDFGFAKQLRAENG----------------LLMTPCYTANFVAPEVL------KRQGYDE-GCDIWSLGI-LLYTMLA-GYTPFANGPS----DTPEEILTRIGSGKFTLSGGNWNT-------------------------------------VSETAKD-LVSKMLHVDPHQRLTAKQVLQ-------HPWI
RSK2C      YEVKEDIGVGSYSVCKRCIHKA--------------TNMEFAVKIIDK-----------------SKRDPTEEIEILLRYG--------QHPNIITLKDVYDDG---------KYVYVVTELMKG--GELLDKILRQF------------------------------FSEREASAVLFTITKTVEYLHAQ---------------GVVHRDLKPSNILYVDESGNPE-----SIRICDFGFAKQLRAENG----------------LLMTPCYTANFVAPEVL------KRQGYDA-ACDIWSLGV-LLYTMLT-GYTPFANGPD----DTPEEILARIGSGKFSLSGGYWNS-------------------------------------VSDTAKD-LVSKMLHVDPHQRLTAALVLR-------HPWI

ASK1       YELVKDIGAGNFGVARLMKVKN--------------SKELVAMKYIERGPK--------------IDENVAREIINHRSL---------RHPNIIRFKEVVLTP---------THLAIAMEYAAG--GELFERICSAGR-----------------------------FSEDEARYFFQQLISGVSYCHAM---------------QICHRDLKLENTLLDGSPAP-------RLKICDFGYSKSSLLHS-----------------RPKSTVGTPAYIAPEVLS-----RREYDGK-MADVWSCGV-TLYVMLV-GAYPFED-------QEDPKNFRKTIQKIMAVQYKIPDYVH-----------------------------------ISQDCKN-LLSRIFVANSLKRITIAEIKK-------HSWF
ASK2       YDVVKDLGAGNFGVARLLRHKD--------------TKELVAMKYIERGRK--------------IDENVAREIINHRSF---------KHPNIIRFKEVILTP---------THLAIVMEYASG--GELFDRICTAGR-----------------------------FSEAEARYFFQQLICGVDYCHSL---------------QICHRDLKLENTLLDGAPAP-------LLKICDFGYSKSSILHS-----------------RPKSTVGTPAYIAPEVLS-----RREYDGK-HADVWSCGV-TLYVMLV-GAYPFED-------PNDPKNFRKTIQRIMAVQYKIPDYVH-----------------------------------ISQECKH-LLSRIFVTNSAKRITLKEIKN-------HPWY

CDPK       YEVGRKLGQGQFGTTFECTRRA--------------SGGKFACKSIPKRKLLCKE----------DYEDVWREIQIMHHLS--------EHANVVRIEGTYEDS---------TAVHLVMELCEG--GELFDRIVQKGH-----------------------------YSERQAARLIKTIVEVVEACHSL---------------GVMHRDLKPENFLFDTIDEDA------KLKATDFGLSVFYKPGE-----------------SFCDVVGSPYYVAPEVL------RK-LYGP-ESDVWSAGV-ILYILLS-GVPPFWA-------ESEPGIFRQILLGKLDFHSEPWPS-------------------------------------ISDSAKD-LIRKMLDQNPKTRLTAHEVLR-------HPWI
AK1        YSLGRKLGQGQFGTTFLCVEKT--------------TGKEFACKSIAKRKLLTDE----------DVEDVRREIQIMHHLA--------GHPNVISIKGAYEDV---------VAVHLVMECCAG--GELFDRIIQRGH-----------------------------YTERKAAELTRTIVGVVEACHSL---------------GVMHRDLKPENFLFVSKHEDS------LLKTIDFGLSMFFKPDD-----------------VFTDVVGSPYYVAPEVL------RK-RYGP-EADVWSAGV-IVYILLS-GVPPFWA-------ETEQGIFEQVLHGDLDFSSDPWPS-------------------------------------ISESAKD-LVRKMLVRDPKKRLTAHQVLC-------HPWV
OsSPK      YTLGRELGQGQFGKTYLCTEIS--------------TGCQYACKTILKSNLRCVS----------DIEDVRREIQIMHHLS--------GQKNIVTIKDTYEDE---------QAVHIVMELCAG--GELFSKIQKRGH-----------------------------YSERKAAELIKIIVGIIETCHSH---------------GVMHRDLKPENFLLLDADDEF------SVKAIDFGLSVFFRPGQ-----------------VFREVVGSPYYIAPEVL------EK-RYGP-EADIWTAGV-ILYVLLT-GVPPFWA-------DTQSGIYEKVLDGRIDFKSNRWPR-------------------------------------ISDSAKD-LIKKMLCPYPLERLKAHEVLK-------HPWI


CaMK Group II

[Current Alignment (10-97) with Viewer]

KIN1/SNF1/Nim1 family


KIN1       WEFVETVGAGSMGKVKLAKHRY--------------TNEVCAVKIVNRATKAFLHKEQMLP{20}RDKRTIREASLGQIL---------YHPHICRLFEMCTLS---------NHFYMLFEYVSG--GQLLDYIIQHGS-----------------------------IREHQARKFARGIASALIYLHAN---------------NIVHRDLKIENIMISDSS---------EIKIIDFGLSNIYDSRK-----------------QLHTFCGSLYFAAPELL------KANPYTGPEVDVWSFGV-VLFVLVC-GKVPFDD-------ENSSVLHEKIKQGKV--EYPQH---------------------------------------LSIEVIS-LLSKMLVVDPKRRATLKQVVE-------HHWM
KIN2       WEFLETVGAGSMGKVKLVKHRQ--------------TKEICVIKIVNRASKAYLHKQHSLP{20}RDKRTVREASLGQIL---------YHPHICRLFEMCTMS---------NHFYMLFEYVSG--GQLLDYIIQHGS-----------------------------LKEHHARKFARGIASALQYLHAN---------------NIVHRDLKIENIMISSSG---------EIKIIDFGLSNIFDYRK-----------------QLHTFCGSLYFAAPELL------KAQPYTGPEVDIWSFGI-VLYVLVC-GKVPFDD-------ENSSILHEKIKKGKV--DYPSH---------------------------------------LSIEVIS-LLTRMIVVDPLRRATLKNVVE-------HPWM
kin1+      YVLGKTIGAGSMGKVKDAHHLK--------------TGEQFAIKIVTR-----LHPDITKA{17}KEIRTVREAALSTLL---------RHPYICEARDVYITN---------SHYYMVFEFVDG--GQMLDYIISHGK-----------------------------LKEKQARKFERQIGSALSYLHQN---------------SVVHRDLKIENILISKTG---------DIKIIDFGLSNLYRRQS-----------------RLRTFCGSLYFAAPELL------NAQPYIGPEVDVWSFGI-VLYVLVC-GKVPFDD-------QNMSALHAKIKKGTV--EYPRY---------------------------------------LSSDCKG-LLSRMLVTDPLKRATLEEVLN-------HPWM
p78        YRLLKTIGKGNFAKVKLARHIL--------------TGREVAIKIIDKTQLNPT-----------SLQKLFREVRIMKIL---------NHPNIVKLFEVIETQ---------KTLYLIMEYASG--GKVFDYLVAHGR-----------------------------MKEKEARSKFRQIVSAVQYCHQK---------------RIVHRDLKAENLLLDADM---------NIKIADFGFSNEFTVGG-----------------KLDTFCGSPPYAAPELF------QGKKYDGPEVDVWSLGV-ILYTLVS-GSLPFDG-------QNLKELRERVLRGKY--RIPFY---------------------------------------MSTDCEN-LLKRFLVLNPIKRGTLEQIMK-------DRWI
SNF1       YQIVKTLGEGSFGKVKLAYHTT--------------TGQKVALKIINKKVLAKSD----------MQGRIEREISYLRLL---------RHPHIIKLYDVIKSK---------DEIIMVIEYIAG--NELFDYIVQRDK-----------------------------MSEQEARRFFQQIISAVEYCHRH---------------KIVHRDLKPENLLLDEHL---------NVKIADFGLSNIMTDGN-----------------FLKTSCGSPNYAAPEVI------SGKLYAGPEVDVWSCGV-ILYVMLC-RRLPFDD-------ESIPVLFKNISNGVY--TLPKF---------------------------------------LSPGAAG-LIKRMLIVNPLNRISIHEIMQ-------DDWF
RKIN1      YYLGKILGVGTFAKVIIAEHKH--------------TRHKVAIKVLNRRQMRAPE----------MEEKAKREIKILRLFIDL------IHPHIIRVYEVIVTP---------KDIFVVMEYCQN--GDLLDYILEKRR-----------------------------LQEDEARRTFQQIISAVEYCHRN---------------KVVHRDLKPENLLLDSKY---------NVKLADFGLSNVMHDGH-----------------FLKTSCGSLNYAAPEVI------SGKLYAGPEIDVWSCGV-ILYALLC-GAVPFDD-------DNIPNLFKKIKGGTY--ILPIY---------------------------------------LSDLVRD-LISRMLIVDPMKRITIGEIRK-------HSWF
AKIN10     YKLGRTLGIGSFGRVKIAEHAL--------------TGHKVAIKILNRRKIKNME----------MEEKVRREIKILRLF---------MHPHIIRLYEVIETP---------TDIYLVMEYVNS--GELFDYIVEKGR-----------------------------LQEDEARNFFQQIISGVEYCHRN---------------MVVHRDLKPENILLDSKC---------NVKIADFGLSNIMRDGH-----------------FLKTSCGSPNYAAPEVI------SGKLYAGPEVDVWSCGV-ILYALLC-GTLPFDD-------ENIPNLFKKIKGGIY--TLPSH---------------------------------------LSPGARD-LIPRMLVVDPMKRVTIPEIRQ-------HPWF
BKIN12     YNLGKTLGLGTFGDVKVAEHKL--------------TGQRVAIKILNRRKMETME----------MEEKANREIKIMRLFIDF------IHPHIIRVYQVIETP---------KDIFIVMEYCNN--GELLDYIIENGR-----------------------------LQEDEARRIFQQILAGVEYCHRI---------------MVVHRDLKPENLLLDSKY---------NVKLADFGLSNVMRDGH-----------------FLKTSCGSLNYAAPEII------SSKLYAGPEVDVWSCGV-ILYALLC-GSVPFDD-------DNIPSLFRKIKGGTY--ILPSY---------------------------------------LSDSARD-LIPKLLNIDPMKRITIHEIRV-------HPWF
WPK4       YELGRVLGKGTFAKVYHARHVQ--------------TGESVAIKVLDREKAVRSG----------LVSHIKREIAVLRRV---------RHPNIVHLFEVMATK---------TKIYFVMELVVA--A-LLRF--SKGR-----------------------------LKEDIARRYFQHLISAVGFCHTR---------------GVFHRDLKPENLLVDEAG---------NLKVSDFGLSAVAEPFQPEG--------------LLHTFCGTRAYVAPEVL------ARRGYEGAKADIWSCGV-ILFVLMA-GYLPFHD-------QNLMAMYRKFTRESS---MSRW---------------------------------------FSKDLTS-LIMRFLDTNPSTRITLPESWR-------AGGS
nim1+      WRLGKTLGTGSTSCVRLAKHAK--------------TGDLAAIKIIPI-----------------RYASIGMEILMMRLL---------RHPNILRLYDVWTDH---------QHMYLALEYVPD--GELFHYIRKHGP-----------------------------LSEREAAHYLSQILDAVAHCHRF---------------RFRHRDLKLENILIKVNEQ--------QIKIADFGMATVEPNDS-----------------CLENYCGSLHYLAPEIV------SHKPYRGAPADVWSCGV-ILYSLLS-NKLPFGG-------QNTDVIYNKIRHGAY--DLPSS---------------------------------------ISSAAQD-LLHRMLDVNPSTRITIPEFFS-------HPFL
YKL453     WKLGKTLGKGSSGRVRLAKNME--------------TGQLAAIKIVPKKKAFVHCSNNGTV{29}NPYGIEREIVIMKLI---------SHTNVMALFEVWENK---------SELYLVLEYVDG--GELFDYLVSKGK-----------------------------LPEREAIHYFKQIVEGVSYCHSF---------------NICHRDLKPENLLLDKKNR--------RIKIADFGMAALELPNK-----------------LLKTSCGSPHYASPEIV------MGRPYHGGPSDVWSCGI-VLFALLT-GHLPFND-------DNIKKLLLKVQSGKY--QMPSN---------------------------------------LSSEARD-LISKILVIDPEKRITTQEILK-------HPLI
YCL24      WKLGETLGFGSTGKVQLAQHER--------------TGHRTAVKVISKSIFNNNGNHSNDDSV--LPYNIEREIVIMKLL---------SHPNVLSLYDVWETN---------NNLYLILEYAEK--GELFNLLVDHGP-----------------------------LPEREAINCFRQIIIGISYCHAL---------------GIVHRDLKPENLLLDSFY---------NIKIADFGMAALQTDAD-----------------LLETSCGSPHYAAPEIV------SGLPYEGFASDVWSCGV-ILFALLT-GRLPFDEEN-----GNVRDLLLKVQKGQF--EMPNDTE-------------------------------------ISRDAQD-LIGKILVVDPRQRIKIRDILS-------HPLL

CaMK Other


MAPKAP2    KVTSQVLGLGINGKVLQIFNKR--------------TQEKFALKMLQ------------------DCPKARREVELHWRAS--------QCPDIVRIVDVYENLYAGR-----KCLLIVMECLDG--GELFSRIQDRGDQA---------------------------FTEREASEIMKSIGEAIQYLHSI---------------NIAHRDVKPENLLYTSKRPNA------ILKLTDFGFAKETTSHN-----------------SLTTPCYTPYYVAPEVL------GPEKYDK-SCDMLVLGV-IMYILLC-GYPPFYSNHGL---AISPGMKTRIRMGQYEFPNPEWSE-------------------------------------VSEEVKM-LIRNLLKTEPTQRMTITEFMN-------HPWI
PfCPK      YFKVRKLGSGAYGEVLLCREKH--------------GHGEKAIKVIKKSQFDKMKYSITNKIE--CDDKIHEEIYNEISLLKSL-----DHPNIIKLFDVFEDK---------KYFYLVTEFYEG--GELFEQIINRHK-----------------------------FDECDAANIMKQILSGICYLHKH---------------NIVHRDIKPENILLENKHSLL------NIKIVDFGLSSFFSKDN-----------------KLRDRLGTAYYIAPEVL------RK-KYNE-KCDVWSCGV-ILYILLC-GYPPFGG-------QNDQDIIKKVEKGKYYFDFNDWKN-------------------------------------ISEEAKE-LIKLMLTYDYNKRITAKEALN-------SKWI
PfPK2      YVLNKKIGKGSFSTAYIGTNIL--------------YGNRVVVKEVDKSKV--------------KESNVYTEIEVLRKV---------MHKYIIKLISAYEQE---------GFVYLVLEYLKG--GELFEYLNNNGP-----------------------------YTEQVAKKAMKRVLIALEALHSN---------------GVVHRDLKMENLMLENPNDPS------SLKIIDFGLASFLNSP------------------SMNMRCGSPGYVAPEIL------KCASYGT-KVDIFSLGV-ILFNILC-GYPPFRG-------NNVKEIFKKNMRCHISFNTKHWIN-------------------------------------KSESVKE-IILWMCCKNPDDRCTALQALG-------HQWF


CMGC Group I

Cyclin-dependent kinases (CDKs) and close relatives family


CDC2Hs     YTKIEKIGEGTYGVVYKGRHKT--------------TGQVVAMKKIRLESEEEG-----------VPSTAIREISLLKEL---------RHPNIVSLQDVLMQD---------SRLYLIFEFLSM---DLKKYLDSIPPGQY--------------------------MDSSLVKSYLYQILQGIVFCHSR---------------RVLHRDLKPQNLLIDDKG---------TIKLADFGLARAFGIPIR----------------VYTHEVVTLWYRSPEVLL-----GSARYST-PVDIWSIGT-IFAELAT-KKPLFHGDSEI---DQLFRIFRALGTPNNE-VWPEVESLQD------------YKN-TFPKWKPGSLASHVKN--LDENGLD-LLSKMLIYDPAKRISGKMALN-------HPYF
Cdk2       FQKVEKIGEGTYGVVYKARNKL--------------TGEVVALKKIRLDTETEG-----------VPSTAIREISLLKEL---------NHPNIVKLLDVIHTE---------NKLYLVFEFLHQ---DLKKFMDASALTG---------------------------IPLPLIKSYLFQLLQGLAFCHSH---------------RVLHRDLKPQNLLINTEG---------AIKLADFGLARAFGVPVR----------------TYTHEVVTLWYRAPEILL-----GCKYYST-AVDIWSLGC-IFAEMVT-RRALFPGDSEI---DQLFRIFRTLGTPDEE-VWPGVTSMPD------------YKP-SFPKWARQDFSKVVPP--LDEDGRS-LLSQMLHYDPNKRISAKAALA-------HPFF
Cdk3       FQKVEKIGEGTYGVVYKAKNRE--------------TGQLVALKKIRLDLEMEG-----------VPSTAIREISLLKEL---------KHPNIVRLLDVVHNE---------RKLYLVFEFLSQ---DLKKYMDSTPGSE---------------------------LPLHLIKSYLFQLLQGVSFCHSH---------------RVIHRDLKPQNLLINELG---------AIKLADFGLARAFGVPLR----------------TYTHEVVTLWYRAPEILL-----GSKFYTT-AVDIWSIGC-IFAEMVT-RKALFPGDSEI---DQLFRIFRMLGTPSED-TWPGVTQLPD------------YKG-SFPKWTRKGLEEIVPN--LEPEGRD-LLMQLLQYDPSQRITAKTALA-------HPYF
Cdk4       YEPVAEIGVGAYGTVYKARDPH--------------SGHFVALKSVRVPNGGGGGGG--------LPISTVREVALLRRLEAF------EHPNVVRLMDVCATSRTDRE----IKVTLVFEHVDQ---DLRTYLDKAPPPG---------------------------LPAETIKDLMRQFLRGLDFLHAN---------------CIVHRDLKPENILVTSGG---------TVKLADFGLARIYSYQM-----------------ALTPVVVTLWYRAPEVLL------QSTYAT-PVDMWSVGC-IFAEMFR-RKPLFCGNSEA---DQLGKIFDLIGLPPED-DWPRDVSLP--------------RG-AFPPRGPRPVQSVVPE--MEESGAQ-LLLEMLTFNPHKRISAFRALQ-------HSYL
Cdk6       YECVAEIGEGAYGKVFKARDLKN-------------GGRFVALKRVRVQTGEEG-----------MPLSTIREVAVLRHLETF------EHPNVVRLFDVCTVSRTDRE----TKLTLVFEHVDQ---DLTTYLDKVPEPG---------------------------VPTETIKDMMFQLLRGLDFLHSH---------------RVVHRDLKPQNILVTSSG---------QIKLADFGLARIYSFQM-----------------ALTSVVVTLWYRAPEVLL------QSSYAT-PVDLWSVGC-IFAEMFR-RKPLFRGSSDV---DQLGKILDVIGLPGEE-DWPRDVALP--------------RQ-AFHSKSAQPIEKFVTD--IDELGKD-LLLKCLTFNPAKRISAYSALS-------HPYF
Cdk5       YEKLEKIGEGTYGTVFKAKNRE--------------THEIVALKRVRLDDDDEG-----------VPSSALREICLLKEL---------KHKNIVRLHDVLHSD---------KKLTLVFEFCDQ---DLKKYFDSCNGD----------------------------LDPEIVKSFLFQLLKGLGFCHSR---------------NVLHRDLKPQNLLINRNG---------ELKLADFGLARAFGIPVR----------------CYSAEVVTLWYRPPDVLF-----GAKLYST-SIDMWSAGC-IFAELANAGRPLFPGNDVD---DQLKRIFRLLGTPTEE-QWPSMTKLPD------------YKP--YPMYPATTSLVNVKPK-LNATGRD-LLQNLLKCNPVQRISAEEALQ-------HPYF
PCTAIRE1   YIKLDKLGEGTYATVYKGKSKL--------------TDNLVALKEIRLEHE-EG-----------APCTAIREVSLLKDL---------KHANIVTLHDIIHTE---------KSLTLVFEYLDK---DLKQYLDDCGNI----------------------------INMHNVKLFLFQLLRGLAYCHRQ---------------KVLHRDLKPQNLLINERG---------ELKLADFGLARAKSIPTK----------------TYSNEVVTLWYRPPDILL-----GSTDYST-QIDMWGVGC-IFYEMAT-GRPLFPGSTVE---EQLHFIFRILGTPTEE-TWPGILSNEE------------FKTYNYPKYRAEALLSHAPR--LDSDGAD-LLTKLLQFEGRNRISAEDAMK-------HPFF
PCTAIRE2   YIKLEKLGEGTYATVYKGRSKL--------------TENLVALKEIRLEHE-EG-----------APCTAIREVSLLKDL---------KHANIVTLHDIVHTD---------KSLTLVFEYLDK---DLKQYMDDCGNI----------------------------ISMHNVKLFLYQILRGLAYCHRR---------------KVLHRDLKPQNLLINEKG---------ELKLADFGLARAKSVPTK----------------TYSNEVVTLWYRPPDVLL-----GSSEYST-QIDMWGVGC-IFFEMAS-GRPLFPGSTVE---DELHLIFRLLGTPSQE-TWPGISSNEE------------FKNYNFPKYKPQPLINHAPR--LDSEGIE-LIRKFLQYESKKRVSAEEAMK-------HVYF
PCTAIRE3   YVKLDKLGEGTYATVFKGKSKL--------------TENLVALKEIRLEHE-EG-----------APCTAIREVSLLKNL---------KHANIVTLHDLIHTD---------RSLTLVFEYLDK---DLKQYLDHCGNL----------------------------ISMHNVKIFMFQLLRGLAYCHTR---------------KILHRDLKPQNLLINERG---------ELKLADFGLARAKSVPTK----------------TYSNEVVTLWYRPPDVLL-----GSTEYST-PIAMWGVGC-IHYEMAT-GRPLFPGSTVK---EELHLIFRLLGTPTEE-TWPGVTAFSE------------FRTYSFPCYLPQPLINHAPR--LDTDGIH-LLSSLLVYESKSRMSAEAALS-------HSYF
CAK/MO15   YEKLDFLGEGQFATVYKARDKN--------------TDRIVAIKKIKLGHRAEANDG--------INRTALREIKLLQEL---------SHPNIIGLLDAFGHK---------SNISLVFDFMET---DLEVIIKDTSLV----------------------------LTPAHIKSYMLMTLQGLEYLHHL---------------WILHRDLKPNNLLLDENG---------VLKLADFGLAKSFGSPNR----------------IYTHQVVTRWYRSPELLF-----GARMYGV-GVDMWAVGC-ILAELLL-RVPFLPGDSDL---DQLTRIFETLGTPTEE-QWPGMSSLPDYV-----------AFKSFP---GTPLHLIFIA--AGDDLLE-LLQGLFTFNPCARCTASQALR-------KRYF
Dm2        FEKIEKIGEGTYGVVYKGRNRL--------------TGQIVAMKKIRLESDDEG-----------VPSTAIREISLLKEL---------KHENIVCLEDVLMEE---------NRIYLIFEFLSM---DLKKYMDSLPVDKH--------------------------MESELVRSYLYQITSAILFCHRR---------------RVLHRDLKPQNLLIDKSG---------LIKVADFGLGRSFGIPVR----------------IYTHEIVTLWYRAPEVLL-----GSPRYSC-PVDIWSIGC-IFAEMAT-RKPLFQGDSEI---DQLFRMFRILKTPTED-IWPGVTSLPD------------YKN-TFPCWSTNQLTNQLKN--LDANGID-LIQKMLIYDPVHRISAKDILE-------HPYF
Dm2c       FQRAEKIGEGTYGIVYKARTNS--------------TGQDVALKKIRLEGETEG-----------VPSTAIREISLLKNL---------KHPNVVQLFDVVISG---------NNLYMIFEYLNM---DLKKLMDKKKDV----------------------------FTPQLIKSYMHQILDAVAFCHTN---------------RILHRDLKPQNLLVDTAG---------KIKLADFGLARAFNVPMR----------------AYTHEVVTLWYRAPEILL-----GTKFYST-GVDIWSLGC-IFSEMIM-RRSLFPGDSEI---DQLYRIFRTLSTPDET-NWPGVTGLPD------------FKT-KFPRWEGTNMPQ--PI--TEHEAHE-LIMSMLCYDPNLRISAKDALQ-------HAYF
Ddcdc2     YQKLEKLGEGTYGKVYKAKEKA--------------TGRMVALKKIRLE--DDG-----------VPSTALREISLLKEV---------PHPNVVSLFDVLHCQ---------NRLYLVFEYLDQ---DLKKYMDSVPA-----------------------------LCPQLIKSYLYQLLKGLAYSHGH---------------RILHRDLKPQNLLIDRQG---------ALKLADFGLARAVSIPVR----------------VYTHEIVTLWYRAPEVLL-----GSKSYSV-PVDMWSVGC-IFGEMLN-KKPLFSGDCEI---DQIFRIFRVLGTPDDS-IWPGVTKLPE------------YVS-TFPNWPGQPYNKIFPR--CEPLALD-LIAKMLQYEPSKRISAKEALL-------HPYF
DdPRK      YSKIEKLGEGTYGIVNKAKNRE--------------TGEIVALKRIRLDSEDEG-----------VPCTAIREISLLKEL---------KHPNIVRLHDVIHTE---------RKLTLVFEYLDQ---DLKKYLDECGGE----------------------------ISKPTIKSFMYQLLKGVAFCHDH---------------RVLHRDLKPQNLLINRKG---------ELKLADFGLARAFGIPVR----------------TYSHEVVTLWYRAPDVLM-----GSRKYST-PIDIWSALC-IFAEMAS--RPLFPGSGTS---DQLFRIFKILGTPNEE-SWPSITELPE------------YKT-DFPVHPAHQLSSIVHG--LDEKGLN-LLSKMLQYDPNQRITAAAALK-------HPYF
LmmCRK1    YERQEKIGEGTYGVVYKARDTS--------------TAATVALKRIRLDSEEEG-----------VPCTAIREISLLKEL---------RHENIVKLLDVCHSE---------HRLTIVFEYLDL---DLKKYLDRENGN----------------------------LDAATIQHFMRDLLRGVAFCHQR---------------SVLHRDLKPQNLLISREK---------ELKLGDFGLGRSFAIPVR----------------KFTNEVVTLWYRPPDVLL-----GSMQYGP-PVDVWSVGC-IFSEMAT-GTPLFAGKNDA---DQLMRIFRFLGTPNNR-VWPSMNQYPNSNNMLSQPE---FLQNFEPEWS-NVLGSVPGYEKLGCAGVD-LLERLLRYEPSERITAADALN-------HPYF
PfC2R      YHGLEKIGEGTYGVVYKAQNNY---------------GETFALKKIRLEKEDEG-----------IPSTTIREISILKEL---------KHSNIVKLYDVIHTK---------KRLVLVFEHLDQ---DLKKLLDVCEGG----------------------------LESVTAKSFLLQLLNGIAYCHDR---------------RVLHRDLKPQNLLINREG---------ELKIADFGLARAFGIPVR----------------KYTHEVVTLWYRAPDVLM-----GSKKYST-TIDIWSVGC-IFAEMVN-GTPLFPGVSEA---DQLMRIFRILGTPNSK-NWPNVTELPK------------YDP-NFTVYEPLPWESFLKG--LDESGID-LLSKMLKLDPNQRITAKQALE-------HAYF
EhC2R      YEKKQQLGEGTYGVVCKAWDTV--------------CNRYVALKKIKQEREDDG-----------IPVTSVREIAVLLEL---------KHPNVVDLYDIYLED---------KFLYLVFEFCDE---DLYQFMSRSSK-----------------------------IPINETRSIVYQILQGLAFCHYH---------------QILHRDMKPQNILINKNG---------TIKLGEFGLARLTTINDR----------------KYTSEVVTLWYRAPEILL-----GATQYGG-AIDIWSTAA-IFGELIN-KEELFKGRCKI---DQLFKIFSQLGTPTED-IWNGVTKLPF------------YLS-TFPKWKAKDLHTIFH---TDERAVD-LLQKMFIYTPEKRISAADALK-------HPFF
CfCdc2R    YRHVVKLGEGTYGMVYKGTEIQ--------------TGRVVAFKRMVVTSDDEG-----------IPGAAIREICLLKEL---------RHNNVVELFEVLFDP---------PKITMIFELCDC---DLKRYMESRPQRLL--------------------------DANTEMRPILKQIFLGLEYLHGR---------------CVVHRDMKPQNIFVNVRGPDFAA{61}IIKIGDFGLARVEEIPVK----------------KYSHEVVTLWYRSPDVLM-----SSALYSY-PVDIWSMGA-IFFEMAT-SKVLFSGRNED---EQLLRMFWLLGSPTKE-TWPSMMTYTGTMERLERS{75}YRL-PVELWFDRPLFKEYM{8}VSPEGID-LLRRCLMYEPNQRITAAEAVH-------HPYL
cdc2+      YQKVEKIGEGTYGVVYKARHKL--------------SGRIVAMKKIRLEDESEG-----------VPSTAIREISLLKEVNDEN-----NRSNCVRLLDILHAE---------SKLYLVFEFLDM---DLKKYMDRISETGATS------------------------LDPRLVQKFTYQLVNGVNFCHSR---------------RIIHRDLKPQNLLIDKEG---------NLKLADFGLARSFGVPLR----------------NYTHEIVTLWYRAPEVLL-----GSRHYST-GVDIWSVGC-IFAEMIR-RSPLFPGDSEI---DEIFKIFQVLGTPNEE-VWPGVTLLQD------------YKS-TFPRWKRMDLHKVVPN--GEEDAIE-LLSAMLVYDPAHRISAKRALQ-------QNYL
CDC28      YKRLEKVGEGTYGVVYKALDLRPGQ-----------GQRVVALKKIRLESEDEG-----------VPSTAIREISLLKEL---------KDDNIVRLYDIVHSDA--------HKLYLVFEFLDL---DLKRYMEGIPKDQP--------------------------LGADIVKKFMMQLCKGIAYCHSH---------------RILHRDLKPQNLLINKDG---------NLKLGDFGLARAFGVPLR----------------AYTHEIVTLWYRAPEVLL-----GGKQYST-GVDTWSIGC-IFAEMCN-RKPIFSGDSEI---DQIFKIFRVLGTPNEA-IWPDIVYLPD------------FKP-SFPQWRRKDLSQVVPS--LDPRGID-LLDKLLAYDPINRISARRAAI-------HPYF
PHO85      FKQLEKLGNGTYATVYKGLNKT--------------TGVYVALKEVKLDSE-EG-----------TPSTAIREISLMKEL---------KHENIVRLYDVIHTE---------NKLTLVFEFMDN---DLKKYMDSRTVANTPRG-----------------------LELNLVKYFQWQLLQGLAFCHEN---------------KILHRDLKPQNLLINKRG---------QLKLGDFGLARAFGIPVN----------------TFSSEVVTLWYRAPDVLM-----GSRTYST-SIDIWSCGC-ILAEMIT-GKPLFPGTNDE---EQLKLIFDIMGTPNES-LWPSVTKLPKYNPN---------IQQRPPRDLRQVLQPHTHEP-LDGNLMD-FLHGLLQLNPDMRLSAKQALH-------HPWF
KIN28      YTKEKKVGEGTYAVVYLGCQHS--------------TGRKIAIKEIKTSEFKDG-----------LDMSAIREVKYLQEM---------QHPNVIELIDIFMAY---------DNLNLVLEFLPT---DLEVVIKDKSIL----------------------------FTPADIKAWMLMTLRGVYHCHRN---------------FILHRDLKPNNLLFSPDG---------QIKVADFGLARAIPAPHE----------------ILTSNVVTRWYRAPELLF-----GAKHYTS-AIDIWSVGV-IFAELML-RIPYLPGQNDV---DQMEVTFRALGTPTDR-DWPEVSSFMTYNK----------LQIYPPPSRDELRKRFIA---ASEYALD-FMCGMLTMNPQKRWTAVQCLE-------SDYF
FpCdc2     YEKVEKIGEGTYGVVYKARDKV--------------TNETIALKKIRLEQEDEG-----------VPSTAIREISLLKEM---------QHSNIVKLQDVVHSE---------KRLYLVFEYLDL---DLKKHMDSTPDFS---------------------------KDLHMIKTYLYQILRGIAYCHSH---------------RVLHRDLKPQNLLIDRRTN--------SLKLADFGLARAFGIPVR----------------TFTHEVVTLWYRAPEILL-----GSHHYST-PVDIWSVGC-IFAEMIS-QKPLFPGDSEI---DQLFKIFRIMGTPYED-TWRGVTSLPD------------YKS-AFPKWKPTDLETFVPN--LDPDGVD-LLSKMLLMDPTKRINARAALE-------HEYF
MsCdc2B    YEKVEKIGEGTYGVVYKARDRA--------------TNETIALKKIRLEQEDEG-----------VPSTAIREISLLKEM---------QHRNIVRLQDVVHSE---------KRLYLVFEYLDL---DLKKFMDSSPEFA---------------------------KDQRQIKMFLYQILCGIAYCHSH---------------RVLHRDLKPQNLLIDRSSN--------AVKLADFGLARAFGIPVR----------------TFTHEVVTLWYRAPEILL-----GSRHYST-PVDVWSVGC-IFAEMIN-QRPLFPGDSEI---DELFKIFRITGTPNEE-TWPGVTSLPD------------FKS-AFPKWPAKDLATQVPN--LEPAGLD-LLSSTCRLDPTRRITARGALE-------HEYF
OsC2R      YLKREVLGEGTYGVVFKAVDTK--------------TGNTVAIKKIRLGKYKEG-----------VNFTALREIKLLKEL---------KDSNIIELIDAFPYK---------GNLHLVFEFMET---DLEAVIRDRNIV----------------------------LSPADTKSYIQMMLKGLAFCHKK---------------WVLHRDMKPNNLLIGADG---------QLKLADFGLARIFGSPER----------------NFTHQVFARWYRAPELLF-----GTKQYGS-AVDIWAAGC-IFAELLL-RRPFLQGSSDI---DQLGKIFAAFGTPKSS-QWPDMVYLPD------------YVEYQFV--SAPPLRSLFPM--ASDDALD-LLSRMFTYDPKARITAQQALE-------HRYF

CMGC Group II

ERK (MAP) kinase family


ERK1       YTQLQYIGEGAYGMVSSAYDHV--------------RKTRVAIKKISPFEHQT------------YCQRTLREIQILLGF---------RHENVIGIRDILRAPTLEAM----RDVYIVQDLMET---DLYKLLKSQQ------------------------------LSNDHICYFLYQILRGLKYIHSA---------------NVLHRDLKPSNLLINTTC---------DLKICDFGLARIADPEHDHTG-------------FLTEYVATRWYRAPEIML-----NSKGYTK-SIDIWSVGC-ILAEMLS-NRPIFPGKHYL---DQLNHILGILGSPSQE-DLN-CIINMKARN---------YLQ-SLPSKTKVAWAKLFPK--SDSKALD-LLDRMLTFNPNKRITVEEALA-------HPYL
ERK2       YTNLSYIGEGAYGMVCSAYDNL--------------NKVRVAIKKISPFEHQT------------YCQRTLREIKILLRF---------RHENIIGINDIIRAPTIEQM----KDVYIVQDLMET---DLYKLLKTQH------------------------------LSNDHICYFLYQILRGLKYIHSA---------------NVLHRDLKPSNSSLNTTC---------DLKICDFGLARVADPDHDHTG-------------FLTEYVATRWYRAPEIML-----NSKGYTK-SIDIWSVGC-ILAEMLS-NRPIFPGKHYL---DQLNHILGILGSPSQE-DLN-CIINLKARN---------YLL-SLPHKNKVPWNRLFPN--ADSKALD-LLDKMLTFNPHKRIEVEQALA-------HPYL
ERK3       YMDLKPLGCGGNGLVFSAVDND--------------CDKRVAIKKIVLTDPQS-------------VKHALREIKIIRRL---------DHDNIVKVFEILGPSGSQLTD{4}NSVLIVQEYMET---DLANVLEQGP------------------------------LLEEHARLFMYQLLRGLKYIHSA---------------NVLHRDLKPANLFINTEDL--------VLKIGDFGLARIMDPHYSHKG-------------HLSEGLVTKWYRSPRLLL-----SPNNYTK-AIDMWAAGC-IFAEMLT-GKTLFAGAHEL---EQMQLILESIPVVHEE-DRQ-ELLSV-IPV---------YIR-NDNTEPHKPLTQLLPG--ISREALD-FLEQILTFSPMDRLTAEEALS-------HPYM
Jnk1       YQNLKPIGSGAQGIVCAAYDAI--------------LERNVAIKKLSRPFQNQT-----------HAKRAYRELVLMKCV---------NHKNIIGLLNVFTPQKSLEEF---QDVYIVMELMDA---NLCQVIQME-------------------------------LDHERMSYLLYQMLCGIKHLHSA---------------GIIHRDLKPSNIVVKSDC---------TLKILDFGLARTAGTSF-----------------MMTPYVVTRYYRAPEVIL-----GM-GYKE-NVDLWSVGC-IMGEMVC-HKILFPGRDYI---DQWNKVIEQLGTPCPE-FMK--KLQPTVRT---------YVE-NRPKYAGYSFEKLF{14}KASQARD-LLSKMLVIDASKRISVDEALQ-------HPYI
DmERKa     YIKLAYIGEGAYGMVVSADDTL--------------TNQRVAIKKISPFEHQT------------YCQRTLREITILTRF---------KHENIIDIRDILRVDSIDQM----RDVYIVQCLMET---DLYKLLKTQR------------------------------LSNDHICYFLYQILRGLKYIHSA---------------NVLHRDLKPSNLLLNKTC---------DLKICDFGLARIADPEHDHTG-------------FLTEYVATRWYRAPEIML-----NSKGYTK-SIDIWSVGC-ILEAMLS-NRPIFPGKHYL---DQLNHILGVLGSPSRD-DLE-CIINEKARN---------YLE-SLPFKPNVPWAKLFPN--ADALALD-LLGKMLTFNPNKRIPVEEALA-------HPYL
CeMPK1     YVNLSYIGEGAYGMVASALDTI--------------TRDRVAIKKISPFEHQT------------FCQRTLREIKILNRF---------KHENIINIQEIIRSETVDSL----KDIYIVQCLMET---DLYKLLKTQK------------------------------LSNDHVCYFLYQILRGLKYIHSA---------------NVLHRDLKPSNLLLNTTC---------DLKICDFGLARVTDPQTDHTG-------------FLTEYVATRWYRAPEIML-----NSKGYTK-SIDVWSVGC-ILAEMLS-NRPLFPGKHYL---DQLNLILAVVGSPSNA-DLQ-CIINDKARS---------YLI-SLPHKPKQPWARLYPG--ADPRALD-LLDKMLTFNPHNRIDIEQALA-------HPYL
CaERK1     YQILEIVGEGAYGIVCSAIHKP--------------SQQKVAIKKIEPFERSM------------LCLRTLRELKLLKHF---------NHENIISILAIQRPINYESF----NEIYLIQELMET---DLHRVIRTQN------------------------------LSDDHIQYFIYQTLRALKAMHSA---------------NVLHRDLKPLNLLLNSNC---------DLKICDFGLARSIASQEDNYG-------------FMTEYVATRWYRAPEIML-----TFQEYTT-AIDVWSVGC-ILAEMLS-GRPLFPGRDYH---NQLWLIMEVLGTPNME-DYY-NIKSKRARE---------YIR-SLPFCKKIPFSELF{17}INPLALD-LLEKLLIFNPAKRITVEDALK-------HPYL
KSS1       YKLVDLIGEGAYGTVCSAIHKP--------------SGIKVAIKKIQPFSKKL------------FVTRTIREIKLLRYFH--------EHENIISILDKVRPVSIDKL----NAVYLVEELMET---DLQKVINNQNSGFST-------------------------LSDDHVQYFTYQILRALKSIHSA---------------QVIHRDIKPSNLLLNSNC---------DLKVCDFGLARCLASSSDSRETLVG---------FMTEYVATRWYRAPEIML-----TFQEYTT-AMDIWSCGC-ILAEMVS-GKPLFPGRDYH---HQLWLILEVLGTPSFE-DFN-QIKSKRAKE---------YIA-NLPMRPPLPWETVWSKTDLNPDMID-LLDKMLQFNPDKRISAAEALR-------HPYL
FUS3       FQLKSLLGEGAYGVVCSATHKP--------------TGEIVAIKKIEPFDKPL------------FALRTLREIKILKHF---------KHENIITIFNIQRPDSFENF----NEVYIIQELMQT---DLHRVISTQM------------------------------LSDDHIQYFIYQTLRAVKVLHGS---------------NVIHRDLKPSNLLINSNC---------DLKVCDFGLARIIDESAADNSEPTGQQS------GMTEYVATRWYRAPEVML-----TSAKYSR-AMDVWSCGC-ILAELFL-RRPIFPGRDYR---HQLLLIFGIIGTPHSD-NDLRCIESPRARE---------YIK-SLPMYPAAPLEKMFPR--VNPKGID-LLQRMLVFDPAKRITAKEALE-------HPYL
HOG1       YNDLNPVGMGAFGLVCSATDTL--------------TSQPVAIKKIMKPFSTAV-----------LAKRTYRELKLLKHL---------RHENLICLQDIFLSPL--------EDIYFVTELQGT---DLHRLLQTRP------------------------------LEKQFVQYFLYQILRGLKYVHSA---------------GVIHRDLKPSNILINENC---------DLKICDFGLARIQDP-------------------QMTGYVSTRYYRAPEIML-----TWQKYDV-EVDIWSAGC-IFAEMIE-GKPLFPGKDHV---HQFSIITDLLGSPPKD-VIN-TICSENTLK---------FVT-SLPHRDPIPFSERFKT--VEPDAVD-LLEKMLVFDPKKRITAADALA-------HPYS
SLT2       FQLIKEIGHGAYGIVCSARFAEAA------------EDTTVAIKKLTNVFSKTL-----------LCKRSLRELKLLRHFR--------GHKNITCLYDMDIVFYPDGS----INGLYLYEELMEC--DMHQIIKSGQP-----------------------------LTDAHYQSFTYQILCGLKYIHSA---------------DVLHRDLKPGNLLVNADC---------QLKICDFGLARGYSENPVENSQ------------FLTEYVATRWYRAPEIML-----SYQGYTK-AIDVWSAGC-ILAEFLG-GKPIFKGKDYV---NQLNQILQVLGTPPDE-TLR-RIGSKNVQD---------YIH-QLGFIPKVPFVNLYPN--ANSQALD-LLEQMLAFDPQKRITVDEALE-------HPYL
spk1+      YEMINLIGQGAYGVVCAALHKP--------------SGLKVAVKKIHPFNHPV------------FCLRTLREIKLLRHF---------RHENIISILDILPPPSYQEL----EDVYIVQELMET---DLYRVIRSQP------------------------------LSDDHCQYFTYQILRALKAMHSA---------------GVVHRDLKPSNLLLNANC---------DLKVADFGLARSTTAQGGNPG-------------FMTEYVATRWYRAPEIML-----SFREYSK-AIDLWSTGC-ILAEMLS-ARPLFPGKDYH---SQITLILNILGTPTMD-DFS-RIKSARARK---------YIK-SLPFTPKVSFKALFPQ--ASPDAID-LLEKLLTFNPDKRITAEEALK-------HPYV
FpERK1     KPPIMPIGKGAYGIVCSAHNSE--------------TNEHVAVKKIANAFDNKI-----------DAKRTLREIKLLRHM---------DHENVVAIRDIVPPPQREVF----NDVYIAYELMDT---DLHQIIRSNQA-----------------------------LSEEHCQYFLYQILRGLKYIHSA---------------NVLHRDLKPSNLLLNANC---------DLKICDFGLARVTSETD-----------------FMTEYVVTRWYRAPELLL-----NSSDYTA-AIDVWSVGC-IFMELMD-RKPLFPGRDHV---HQLRLLMELIGTPSED-DLG-FLNENAKR----------YIR-QLPPYRRQSFQEKFPH--VHPEAID-LVEKMLTFDPRKRITVEDALA-------HPYL
NTF3       YVPIKPIGRGAYGIVCSSVNRE--------------TNEKVAIKKINNAFENRI-----------DALRTLRELKLLRHL---------RHENVIALKDVMMPIHRRSF----KDVYLVYELMDT---DLHQIIKSSQT-----------------------------LSNDHCQYFLFQLLRGLKYLHSA---------------NILHRDLKPGNLLINANC---------DLKICDFGLARTSSGKDQ----------------FMTEYVVTRWYRAPELLL-----CCDNYGT-SIDVWSVGC-IFAELLG-RKPVFPGTECL---NQLKLIINILGSQREE-DIE-FIDNPKARK---------YIK-SLPYSPGTPFSRLYPH--AHPLAID-LLQRMLVFDPSKRISVIEALQ-------HPYM
FpMPK7     YVPIKPIGRGAYGVVCSSINRE--------------TNERVAIKKIHNVFENRV-----------DALRTLRELKLLRHV---------RHENVIALKDVMLPANRTSF----KDVYLVYELMDT---DLHQIIKSSQS-----------------------------LSDDHCKYFLFQLLRGLKYLHSA---------------NILHRDLKPGNLLVNANC---------DLKICDFGLARTSQGNEQ----------------FMTEYVVTRWYRAPELLL-----CCDNYGT-SIDVWSVGC-IFAEILG-RKPIFPGTECL---NQLKLIINVVGSQQES-DIR-FIDNPKARR---------FIK-SLPYSRGTHLSNLYPQ--ANPLAID-LLQRMLVFEPTKRISVTDALL-------HPYM
FpMPK6     KPPIMPIGKGAYGIVCSAMNSE--------------TNESVAIKKIANAFDNKI-----------DAKRTLREIKLLRHM---------DHENIVAIRDIIPPPLRNAF----NDVYIAYELMDT---DLHQIIRSNQA-----------------------------LSEEHCQYFLYQILRGLKYIHSA---------------NVLHRDLKPSNLLLNANC---------DLKICDFGLARVTSESD-----------------FMTEYVVTRWYRAPELLL-----NSSDYTA-AIDVWSVGC-IFMELMD-RKPLFPGRDHV---HQLRLLMELIGTPSEE-ELE-FLNENAKR----------YIR-QLPPYPRQSITDKFPT--VHPLAID-LIEKMLTFDPRRRITVLDALA-------HPYL
FpMPK5     VPPIRPIGRGAYGFVCPAVDSE--------------THEEIAIKKIGKAFDNKV-----------DAKRTLREIKLLRHL---------EHENVVVIKDIIRPPKKEDF----VDVYIVFELMDT---DLHQIIRSNQS-----------------------------LNDDHCQYFLYQILRGLKYIHSA---------------NVLHRDLKPSNLLLNSNC---------DLKITDFGLARTTSETE-----------------YMTEYVVTRWYRAPELLL-----NSSEYTS-AIDVWSVGC-IFAEIMT-REPLFPGKDYV---HQLKLITELIGSPDGA-SLE-FLRSANGGK---------YVK-ELPKFPRQNFSARFPS--MNSTAID-LLEKMLVFDPVKRITVEEALC-------YPYL
FpMPK4     VPPLRPIGRGAYGIVCAATNSE--------------TGEEVAIKKIGNAFDNII-----------DAKRTLREIKLLKHM---------DHENVIAVKDIIKPPQRENF----NDVYIVYELMDT---DLHQIIRSNQP-----------------------------LTDDHCRFFLYQLLRGLKYVHSA---------------NVLHRDLKPSNLLLNANC---------DLKLGDFGLARTKSETD-----------------FMTEYVVTRWYRAPELLL-----NCSEYTA-AIDIWSVGC-ILGETMT-REPLFPGKDYV---HQLRLITELIGSPDDS-SLG-FLRSDNARR---------YVR-QLPQYPRQNFAARFPN--MSAGAVD-LLEKMLVFEPSRRITVDEALC-------HPYL
FpMPK3     RPPIIPIGRGAYGIVCSVLDTE--------------TNELVAMKKIANAFDNHM-----------DAKRTLREIKLLRHL---------DHENIIAIRDVVPPPLRRQF----SDVYISTELMDT---DLHQIIRSNQS-----------------------------LSEEHCQYFLYQLLRGLKYIHSA---------------NIIHRDLKPSNLLLNANC---------DLKICDFGLARPTSEND-----------------FMTEYVVTRWYRAPELLL-----NSSDYTA-AIDVWSVGC-IFMELMN-RKPLFPGKDHV---HQMRLLTELLGTPTES-DLG-FTHNEDAKR---------YIR-QLPNFPRQPLAKLFSH--VNPMAID-LVDRMLTFDPNRRITVEQALN-------HQYL
FpMPK2     YMPIKPIGRGAYGVVCSSVNRE--------------SNERVAIKKIHNVFENRI-----------DALRTLRELKLLRHL---------RHENVVALKDVMMANHKRSF----KDVYLVYELMDT---DLHQIIKSSQV-----------------------------LSNDHCQYFLFQLLRGLKYIHSA---------------NILHRDLKPGNLLVNANC---------DLKICDFGLARTSNTKGQ----------------FMTEYVVTRWYRAPELLL-----CCDNYGT-SIDVWSVGC-IFAELLG-RKPVFPGTECL---NQIKLIINILGSQREE-DLE-FIDNPKAKR---------YIE-SLPYSPGISFSRLYPG--ANVLAID-LLQKILVLDPSKRISVTEALQ-------HPYM
FpMPK1     YMPIKPIGRGAYGVVCSSVNSD--------------TNEKVAIKKIHNVYENRI-----------DALRTLRELKLLRHL---------RHENVIALKDVMMPIHKMSF----KDVYLVYELMDT---DLHQIIKSSQR-----------------------------LSNDHCQYFLFQLLRGLKYIHSA---------------NILHRDLKPGNLLVNANC---------DLKICDFGLARASNTKGQ----------------FMTEYVVTRWYRAPELLL-----CCDNYGT-SIDVWSVGC-IFAELLG-RKPIFQGTECL---NQLKLIVNIIGSQREE-DLE-FIVNPKAKR---------YIR-SLPYSPGMSLSRLYPC--AHVLAID-LLQKMLVFDPSKRISASEALQ-------HPYM

CMGC Group III

Glycogen synthase kinase 3 (GSK3) family


GSK3a      YTDIKVIGNGSFGVVYQARLAE--------------TRELVAIKKVLQ-----------------DKRFKNRELQIMRKL---------DHCNIVRLRYFFYSSGEKKDE---LYLNLVLEYVPE---TVYRVARHFTKAKLI-------------------------IPIIYVKVYMYQLFRSLAYIHSQ---------------GVCHRDIKPQNLLVDPDTA--------VLKLCDFGSAKQLVRGE-----------------PNVSYICSRYYRAPELIF-----GATDYTS-SIDVWSAGC-VLAELLL-GQPIFPGDSGV---DQLVEIIKVLGTPTRE-QIR-EMNPNYTEFK--------FPQIKAHPWTKVFKSR------TPPEAIA-LCSSLLEYTPSSRLSPLEACA-------HSFF
GSK3b      YTDTKVIGNGSFGVVYQAKLCD--------------SGELVAIKKVLQ-----------------DKRFKNRELQIMRKL---------DHCNIVRLRYFFYSSGEKKDE---VYLNLVLDYVPE---TVYRVARHYSRAKQT-------------------------LPVIYVKLYMYQLFRSLAYIHSF---------------GICHRDIKPQNLLLDPDTA--------VLKLCDFGSAKQLVRGE-----------------PNVSYICSRYYRAPELIF-----GATDYTS-SIDVWSAGC-VLAELLL-GQPIFPGDSGV---DQLVEIIKVLGTPTRE-QIR-EMNPNYTEFK--------FPQIKAHPWTKVFRPR------TPPEAIA-LCSRLLEYTPTARLTPLEACA-------HSFF
Sgg/zw3    YTDTKVIGNGSFGVVFQAKLCD--------------TGELVAIKKVLQ-----------------DRRFKNRELQIMRKL---------EHCNIVKLLYFFYSSGEKRDE---VFLNLVLEYIPE---TVYKVARQYAKTKQT-------------------------IPINFIRLYMYQLFRSLAYIHSL---------------GICHRDIKPQNLLLDPETA--------VLKLCDFGSAKQLLHGE-----------------PNVSYICSRYYRAPELIF-----GAINYTT-KIDVWSAGC-ILAELLL-GQPIFPGDSGV---DQLVEVIKVLGTPTRE-QIR-EMNPNYTEFK--------FPQIKSHPWQKVFRIR------TPTEAIN-LVSLLLEYTPSARITPLKACA-------HPFF
MCK1       VKEYRKIGRGAFGTVVQAYLTQDKKN----------WLGPFAIKKVPA-----------------HTEYKSRELQILRIA---------DHPNIVKLQYFFTHLSPQDNK---VYQHLAMECLPE---TLQIEINRYVTNKLE-------------------------MPLKHIRLYTYQIARGMLYLHGL---------------GVCHRDIKPSNVLVDPETG--------VLKICDFGSAKKLEHNQ-----------------PSISYICSRFYRAPELII-----GCTQYTT-QIDIWGLGC-VMGEMLI-GKAIFQGQEPL---LQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPL-----FSGSSQQRFEKYF-GH------SGPDGID-LLMKILVYEPQQRLSPRRILA-------HQFF
MDS1       FPTTEVVGHGSFGVVFATVIQE--------------TNEKVAIKKVLQ-----------------DKRFKNRELEIMKML---------SHINIIDLKYFFYERDSQ-DE---IYLNLILEYMPQ---SLYQRLRHFVHQRTP-------------------------MSRLEIKYYMFQLFKSLNYLHHFA--------------NVCHRDIKPQNLLVDPETW--------SLKLCDFGSAKQLKPTE-----------------PNVSYICSRYYRAPELIF-----GATNYTN-QIDIWSSGC-VMAELLL-GQPMFPGESGI---DQLVEIIKILGTPSKQ-EIC-SMNPNYMEHK--------FPQIKPIPLSRVFK-K------EDDQTVE-FLADVLKYDPLERFNALQCLC-------SPYF
ASK-a      YMAERVVGHGSFGVVFQAKCLE--------------TGETVAIKKVLQ-----------------DRRYKNRELQTMRLL---------DHPNVVSLKHCFFSTTEK-DE---LYLNLVLEYVPE---TVHRVIKHYNKLNQR-------------------------MPLIYVKLYTYQIFRALSYIHRCI--------------GVCHRDIKPQNLLVNPHTH--------QVKLCDFGSAKVLVKGE-----------------PNISYICSRYYRAPELIF-----GATEYTT-AIDVWSAGC-VLAELLL-GQPLFPGESGV---DQLVHIIKVLGTPTRE-EIK-CMNPNYTEFK--------FPQIKAHPWHKIFHKR------MPPEAVD-LVSRLLQYSPNLRSAALDTLV-------HPFF
ASK-g      YMAERVVGHGSFGVVFQAKCLE--------------TGETVAIKKVLQ-----------------DRRYKNRELQTMRLL---------DHPNVVSLKHCFFSTTEK-DE---LYLNLVLEYVPE---TVHRVIKHYNKLNQR-------------------------MPLVYVKLYTYQIFRSLSYIHRCI--------------GVCHRDIKPQNLLVNPHTH--------QVKLCDFGSAKVLVKGE-----------------PNISYICSRYYRAPELIF-----GATEYTT-AIDVWSAGC-VLAELLL-GQPLFPGESGV---DQLVEIIKVLGTPTRE-EIK-CMNPNYTEFK--------FPQIKAHPWHKIFHKR------MPPEAVD-LVSRLLQYSPNLRCAALDSLV-------HPFF

CMGC Group IV

Casein kinase II family


CKIIa      YQLVRKLGRGKYSEVFEAINIT--------------NNEKVVVKILKPV----------------KKKKIKREIKILENLR--------GGPNIITLADIVKDPVS-------RTPALVFEHVNN--TDFKQLYQT--------------------------------LTDYDIRFYMYEILKALDYCHSM---------------GIMHRDVKPHNVMIDHEHR--------KLRLIDWGLAEFYHPGQ-----------------EYNVRVASRYFKGPELLV-----DYQMYDY-SLDMWSLGC-MLASMIFRKEPFFHGHDNY---DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI------LGRHSRKRWERFVHSENQHL--VSPEALD-FLDKLLRYDHQSRLTAREAME-------HPYF
CKIIa'     YQLVRKLGRGKYSEVFEAINIT--------------NNIRVVVKILKPV----------------KKKKIKREVKILENLR--------GGTNIIKLIDTVKDPVS-------KTPALVFEYINN--TDFKQLYQI--------------------------------LTDFDIRFYMYELLKALDYCHSK---------------GIMHRDVKPHNVMIDHQQK--------KLRLIDWGLAEFYHPAQ-----------------EYNVRVASRYFLGPELLV-----DYQMYDY-SLDMWSLGC-MLASMIFRREPFFHGQDNY---DQLVRIAKVLGTEELYGYLKKYGIDLDPHFNDI------LGQHSRKRWENFIHSENRHL--VSPEALD-LLDKLLRYDHQQRLTAKEAME-------HPYF
DmCKII     YQLVRKLGRGKYSEVFEAINIT--------------TTEKCVVKILKPV----------------KKKKIKREIKILENLR--------GGTNLA----VVKDPVS-------RTPALIFEHVNN--TDFKQLYQT--------------------------------LTDYEIRYYLFELLKALDYCHSM---------------GIMHRDVKPHNVMIDHENR--------KLRLIDWGLAEFYHPGQ-----------------EYNVRVASRYFKGPELLV-----DYQMYDY-SLDMWSLGC-MLASMIFRKEPFFHGHDNY---DQLVRIAKVLGTEELYAYLDKYNIDLDPRFHDI------LQRHSRKRWERFVHSDNQHL--VSPEALD-FLDKLLRYDHVDRLTAREAMA-------HPYF
CeCKII     YQLVRKLGRGKYSEVFEGFKMS--------------TDEKVVVKILIPV----------------KKKKIKREIKILENLR--------GGTNIITLLDVVKDPIS-------RTPALIFEHVNN--SDFKQLYQT--------------------------------LSDYDIRYYLYELLKALDFCHSQ---------------GIMHRDVKPHNVMIDAEKR--------ELRLIDWGLAEFYHPRQ-----------------DYNVRVASRYFKGPELLV-----DYQCYDY-SLDMWSLGC-MLASMIFRKEPFFHGHDNY---DQLVRIAKVLGTDELYEYIARYHIDLDPRFNDI------LGRHSRKRWERFIHAENQHL--VTPEALD-FLDKLLRYDHAERLTAQEAMG-------HEYF
TpCKII     YEIVRKIGRGKFSEVFEGINTV--------------TKDKCVIKILKPV----------------KKKKIKREIKILQNLR--------GGPNIIKLLDIVKDPQS-------RTPSLIFEHVNN--TDFKTLYPT--------------------------------LSIQDIKYYIYQLLKAMNYCHSQ---------------GIMHRDIKPHNVMIDHEKK--------ILRLIDWGLAEFYHPEQ-----------------EYSVRVATRYYKGPELLV-----DMRYYDY-SLDIWSIGC-MLAGIIFKKEPFFYGGDNY---DQLVKIAKVLGTEDLHRYFEKYGLKFAPAYQEI------LGNHSKKPWTKFVHHENQHL--VSPEVMD-LLDRMLVYDHTKRITPLEAME-------HPFF
DdCKIIa    YEIIRKIGRGKYSEVFEGANIK--------------NNEKCVIKVLKPV----------------KKKKIKREIKILQNLC--------GGPNIITLYDVVRDPQS-------KTPSLIFEYINN--TDFKHLSPT--------------------------------LTDFDVRYYIRELLHALDFCHSN---------------GIMHRDVKPSNVMIDHQKR--------KLYLIDWGLAEFYHPNQ-----------------DYNVRVASRPYKGPELLV-----DMEDYDY-SLDMWSLGC-MFAGMLFQKDPFFHGHDNI---DQLVKIVKILGTEEFYAYLDKYGIVVDHTILSI------IGKHPKKPWSRFITKENQHL--AVPEAID-FLEKLLRYDPAERLTTREAME-------HPYF
CKA1       YEIENKVGRGKYSEVFQGVKLD--------------SKVKIVIKMLKPV----------------KKKKIKREIKILTDLS--------GHANIIHLFDIIKDPIS-------KTPALVFEYVDN--VDFRILYPK--------------------------------LTDLEIRFYMFELLKALDYCHSM---------------GIMHRDVKPHNVMIDHKNK--------KLRLIDWGLAEFYHVNM-----------------EYNVRVASRFFKGPELLV-----DYRMYDY-SLDLWSFGT-MLASMIFKREPFFHGTSNT---DQLVKIVKVLGTSDFEKYLLKYEITLPREFYD-------MDQYSRKPWHRFINDGNKHLS-GNDEIID-LIDKLLRYDHQERLTAKEAMG-------HPWF
CKA2       YEIINKIGRGKYSEVFSGRCIV--------------NNQKCVIKVLKPV----------------KMKKIYRELKILTNLT--------GGPNVVGLYDIVQDADS-------KIPALIFEEIKN--VDFRTLYPT--------------------------------FKLPDIQYYFTQLLIALDYCHSM---------------GIMHRDVKPQNVMIDPTER--------KLRLIDWGLAEFYHPGV-----------------DYNVRVASRYHKGPELLV-----NLNQYDY-SLDLWSVGC-MLAAIVFKKEPFFKGSSNP---DQLVKIATVLGTKELLGYLGKYGLHLPSEYDNI------MRDFTKKSWTHLLTSETK-L--AVPEVVD-LIDNLLRYDHQERLTAKEAMD-------HKFF
SpCka1     YEIIRKVGRGKYSEVFEGLNVL--------------NNRKCIIKVLKPV----------------KYKKIKREIKILQNLA--------GGPNIISLLDIVRDPES-------KTPSLIFEFVDN--IDFRTLYPT--------------------------------LSDYDIRYYLYELLKALDFCHSR---------------GIMHRDVKPHNVIIVHKKR--------KLRLIDWGLAEFYHAGM-----------------EYNVRVASRYFKGPELLV-----DFREYDY-SLDIWSFGV-MFAALIFKKEPFFRGRDNY---DQLVKIAKVLGTDELFAYVQKYQIVLDRQYDNI------LGQYPKRDWYFVNRDNRS-L--ANDEAID-LLNRLLRYDHQERLTCQEAMA-------HPYF
FpCKII     YEVVRKVGRGKYSEVFEGINVN--------------NNEKCIIKILKPV----------------KKKKIKREIKILQNLC--------GGPNIVKLLDIVRDQHS-------KTPSLIFEYVNN--TDFKVLYPT--------------------------------LTDYDIRYYIYELLKALDYCHSQ---------------GIMDRDVKPHNVMIDHELR--------KLRLIDWGLAEFYHPGK-----------------EYNVRVASRYFKGPELLV-----DLQDYDY-SLDMWSLGC-MFAGMIFRKEPFFYGHDNH---DQLVKIAKVLGTDGLNVYLNKYRIELDPQLEAL------VGRHSRKPWLKFMNADNQHL--VSPEAID-FLDKLLRYDHQERLTALEAMT-------HPYF

CMGC Group V

Clk family


Clk        DEIVDTLGEGAFGKVVECADHKA-------------GGRHVAVKIVKNVDR--------------YCEAARSEIQVLEHLNT-------TDPNSTFRCVQMLEWFEHH-----GHICIVFELLGL---STYDFIKENGFLP---------------------------FRLDHIRKMAYQICKSVNFLHSN---------------KLTHTDLKPENILFVQSDYTEAY{14}DIKVVDFGSATYDDE-------------------HHSTLVSTRHYRAPEVIL------ALGWSQ-PCDVWSIGC-ILIEYYL-GFTVFPTHDSK---EHLAMMERILGPL-PKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFD-LIQKMLEYDPAKRITLREALK-------HPFF
PSK-G1     YEIVSTLGEGTFGRVVQSVDHRR-------------GGARVALKIIKNVEK--------------YKEAARLEINVLEKINE-------KDPDNKNLCVQMFDWFDYH-----GHMCISFELLGL---STFDFLKDNNYLP---------------------------YPIHQVRHMAFQLCQAVKFLHDN---------------KLTHTDLKPENILFVNSDYELTY{14}AARVVDFGSATFDHE-------------------HHSTIVSTRHYRAPEVIL------ELGWSQ-PCDVWSIGC-IIFEYYV-GFTLFQTHDNR---EHLAMMERILGPI-PSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAKRLTLGEALQ-------HPFF
Doa        YKIMATLGEGTFGRVVKVKDMER--------------DYCMALKIIKNVEK--------------YREAAKLEINALEKIAQ-------KDPHCDHLCVKMIDWFDYH-----GHMCIVFEMLGL---SVFDFLRENNYEP---------------------------YPLDQVRHMAYQLCYSVKFLHDN---------------RLTHTDLKPENILFVDSDYTSHY{14}DVRLIDFGSATFDHE-------------------HHSTIVSTRHYRAPEVIL------ELGWSQ-PCDVWSIGC-ILFELYL-GITLFQTHDNR---EHLAMMERILGQI-PYRMARKT-KTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFS-LIKKMLEYEPSSRITLGEALH-------HPFF
KNS1       FVVKDLLGQGTFGKVLKCIDNKY-------------EPNYVAVKVIRAVDR--------------YREAAKTELRILQTILN-------NDPQGQFQCLLLRECFDYK-----NHICLVTDLYGR---SIYDFMCSNGIAG----------------------------SPALISGHCRQLIRSVCFLHDL---------------GIIHTDLKPENILICDETHIAQK{27}EIKIIDFGSAIFHYE-------------------YHPPVISTRHYRAPEIVL------GLGWSF-PCDIWSIAC-VLVELVI-GESLYPIHENL---EHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNS{80}THSSSSSTTDELDKETFLFWYWFID-LLRKMFEFDPTKRITAKDALD-------HEWF
PSK-H2     YEVLKVIGKGSFGQVVKAYDHK--------------VHQHVALKMVRNEKR--------------FHRQAAEEIRILEHLRK-------QDKDNTMNVIHMLENFTFR-----NHICMTFELLSM---NLYELIKKNKFQG---------------------------FSLPLVRKFAHSILQCLDALHKN---------------RIIHCDLKPENILLKQQGRS-------GIKVIDFGSSCYEHQ-------------------RVYTYIQSRFYRAPEVIL------GPWYGM-PIDMWSLGC-ILAELLT-GYPLLPGEDEG---DQLACMIELLGMP-SQKLLDASKRAKNFVSSKGYP{19}SRRGKLRGPPESREWGNALKGCDDPLFLG-FLKQCLGWDPAVRMTPGQALR-------HPWL
YAK1       YLVLDILGQGTFGQVVKCQNLL--------------TKEILAVKVVKSRTE--------------YLTQSITEAKILELLNQK------IDPNKHHFLRMYDSFVHK------NHLCLVFELLSN---NLYELLKQNKFHG---------------------------LSIQLIRTFTTQILDSLCVLKES---------------KLIHCDLKPENILLCAPDKP-------ELKIIDFGSSCEEAR-------------------TVYTYIQSRFYRAPEIIL------GIPYST-SIDMWSLGC-IVAELFL-GIPIFPGASEY---NQLTRIIDTLGYP-PSWMIDMGKNSGKFMKKLAPE{41}RNYRYPKSIQNSQELID-QEMQNRECLIH-FLGGVLNLNPLERWTPQQAML-------HPFI
dsk1+      YVVERKLGWGHFSTVWLAYDRA--------------AKRRVALKVVRSAEH--------------YRETSIDEIRILQKIREGDE----KHLGKKHIISLLDYFVHRGPNG--AHVCMVFEVLGE---NLLSLIQSYGHRG---------------------------VPVGIVKQIAYQLLIALDYLHREC--------------GIIHTDLKPENVLICIDQDALQ{124}TVKIADLGNACWTRK-------------------HFTNDVQTRQYRSPEVIL------GCRWGA-SADCWSFAC-IIFELLT-GDYLFDPRNGN---DHIAQIIELLVNY-PKQMALSGKHSRDLFNRRGELRNIHKLKFWPLKDVLEQ-KYHFS-AELAQQISD-FLSPMLCFDPAKRTNAGYMSN-------SPWL
prp1+      YIVQSNLGKGMFSTVVSALDRN--------------RNQTFAIKIIRNNEV--------------MYKEGLKEVSILERLQAA------DREGKQHIIHYERHFMHK------NHLCMVFEMLSL---NLRDILKKFGRNVG--------------------------LSIKAVRLYAYQMFMALDLLKQC---------------NVIHSDIKPDNMLVNEKRN--------ILKICDLGSASDASEN------------------EITPYLVSRFYRAPEIIL------GFPYSC-PIDTWSVGC-SLYELYT-GQILFPGRTNN---QIASLYDGM

CMGC Group Other


GTAp58     FQCLNRIEEGTYGVVYRAKDKK--------------TDEIVALKRLKMEKEKEG-----------FPITSLREINTILKA---------QHPNIVTVREIVVGSNM-------DKIYIVMNYVEH---DLKSLMETMKQP----------------------------FLPGEVKTLMIQLLRGVKHLHDN---------------WILHRDLKTSNLLLSHAG---------ILKVGDFGLAREYGSPLK----------------AYTPVVVTLWYRAPELLL-----GAKEYST-AVDMWSVGC-IFGELLT-QKPLFPGKSEI---DQINKVFKDLGTPSEK-IWPGYSELPAVKK----------MTFSEHPYNNLRKRFGAL---LSDQGFD-LMNKFLTYFPGRRISAEDGLK-------HEYF
Dcdrk      FEKLNRVGEGSYGIVYRARDTR--------------SNEIVALKKVRMDQEKDG-----------LPISGLREIMILKQC---------HHENIVRLREVVVGKSL-------DSIFLVMDFCEQ---DLASVLDNMSQP----------------------------FTESEVKCITLQVLKALKYLHSR---------------FMIHRDLKVSNLLMTDKG---------CIKVADFGLARMFSNPPK----------------PMTPQMVTLWYRAPELLL-----GCRTHTT-AVDMWAFGC-ILGELLL-GKPLLPGNSEI---AQLDMIIDLLGAPSES-IWPGFADLPAVQN----------FTLSQQPYNNLTPKFHM----IGQSGRN-LLNILFIYNPKTRATAEECLK-------SKYF
CHED       FDIIGIIGEGTYGQVYKARDKD--------------TGEMVALKKVRLDNEKEG-----------FPITAIREIKILRQL---------THQSIINMKEIVTDKEDALDF{4}GAFYVAFEYMDH---DLMGLLESGLVH----------------------------FYENHIKSFMRQLMEGLDYCHKK---------------NFLHRDIKCSNILLNNRG---------QIKLADFGLARLYSSEESR---------------PYTNKVITLWYRPPELLL-----GEERYTP-AIDVWSCGC-ILGELFT-KKPIFQANQEL---AQLELISRICGSPCPA-VWPDVIKLPY-------------FNTMKPKKQYRRKLREEFVF-IPAAALD-LFDYMLALDPSKRCTAEQALQ-------CEFL
CTK1       YLRIMQVGEGTYGKVYKAKNTN--------------TEKLVALKKLRLQGEREG-----------FPITSIREIKLLQSF---------DHPNVSTIKEIMVESQ--------KTVYMIFEYADN---DLSGLLLNKEVQ----------------------------ISHSQCKHLFKQLLLGMEYLHDN---------------KILHRDVKGSNILIDNQG---------NLKITDFGLARKMNSRA-----------------DYTNRVITLWYRPPELLL-----GTTNYGT-EVDMWGCGC-LLVELFN-KTAIFQGSNEL---EQIESIFKIMGTPTIN-SWPTLYDMPWFFM---------IMPQQTTKYVNNFSEKFKSVL-PSSKCLQ-LAINLLCYDQTKRFSATEALQ-------SDYF
SGV1       YREDEKLGQGTFGEVYKGIHLE--------------TQRQVAMKKIIVSVEKDL-----------FPITAQREITILKRL---------NHKNIIKLIEMVYDHSPDITN{7}KSFYMILPYMVA---DLSGVLHNPRIN----------------------------LEMCDIKNMMLQILEGLNYIHCA---------------KFMHRDIKTANILIDHNG---------VLKLADFGLARLYYGCPPNLKYPGGAGSGA----KYTSVVVTRWYRAPELVL-----GDKQYTT-AVDIWGVGC-VFAEFFE-KKPILQGKTDI---DQGHVIFKLLGTPTEE-DWAVARYLPG-------------AELTTTNYKPTLRERFGKY--LSETGLD-FLGQLLALDPYKRLTAMSAKH-------HPWF
KKIALRE    YEKIGKIGEGSYGVVFKCRNRD--------------TGQIVAIKKFLESEDDPV-----------IKKIALREIRMLKQL---------KHPNLVNLLEVFRRK---------RRLHLVFEYCDH---TVLHELDRYQRG----------------------------VPEHLVKSITWQTLQAVNFCHKH---------------NCIHRDVKPENILITKHS---------VIKLCDFGFARLLTGPSD----------------YYTDYVATRWYRSPELLV-----GDTQYGP-PVDVWAIGC-VFAELLS-GVPLWPGKSDV---DQLYLIRKTLGDLIPR-HQQVFSTNQYFSG---------VKI--PDPEDMEPLELKFPN--ISYPALG-LLKGCLHMDPTERLTCEQLLH-------HPYF
MAK        YTTMRQLGDGTYGSVLMGKSNE--------------SGELVAIKRMKRKFYSW------------DECMNLREVKSLKKL---------NHANVIKLKEVIREN---------DHLYFIFEYMKE---NLYQLMKD--RNKL--------------------------FPESVIRNIMYQILQGLAFIHKH---------------GFFHRDMKPENLLCMGPE---------LVKIADFGLARELRSQP-----------------PYTDYVSTRWYRAPEVLL-----RSSVYSS-PIDVWAVGS-IMAELYT-FRPLFPGTSEV---DEIFKICQVLGTPKKS-DWPEGYQLASSMN---------FR---FPQCIPINLKTLIPN--ASSEAIQ-LMTEMLNWDPKKRPTASQALK-------HPYF
SME1       YQLIEKLGAGSFGCVTLAKAQFPLSNILGKQH{20}TQGVVAIKTMMTKLHTL------------QDYTRVREIKFILAIP--------ANDHLIQIFEVFIDSEN-------YQLHIVMECMEQ---NLYQMMKHR-RRRV--------------------------FSIPSLKSILSQILAGLKHIHEH---------------NFFHRDLKPENILITPSTQYFEK{12}VIKLADFGLARHVENKN-----------------PYTAYVSTRWYRSPEILL-----RSGYYSK-PLDIWAFGC-VAVEVTV-FRALFPGANEI---DQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDD{5}HKLNLKLPYVEGSSLDHLLSSSQLSDLSE-VVKKCLRWDPNERATAQELCE-------MPFF
csk1+      LTDIRHLTDGTISEVFVGERKN--------------SKKLYVIKVQGLVFKR-------------PPHDAMRGKLILESI---------GHPHIERIVDSFIDNEA-------GSVYLITSFKSF---VLSDVMDE--------------------------------ISIDTKCKIVLQISSALEYLEKH---------------GILHRDIHPNNILLDSMNG--------PAYLSDFSIAWSKQHPGEEVQ-------------ELIPQIGTGHYRAIETLF-----GCHSYGH-EVDRWTFGI-LIAELFS-NQALFDDGSSE{6}RLTSSIIQTLGTPNPS-MWPELSTFPDWNK---------FI---FHEYPPKPWSEILP---SVDTSIQ-YIVSHLVTYSN-RASPSFVIE-------SFPK
MHK        YKILEELGDGTCGSVYKAVNLE--------------TYEVVAVKKMKRKFYYW------------EECVNLREVKALRKL---------KHPHIIKLKEIVREH---------NELFFIFECMDH---NLYHIMKE--RERP--------------------------FSEGEIRSFMSQMLQGLAHMHKN---------------GYFHRDLKPENLLVTNN----------ILKIADFGLAREVASMP-----------------PYTEYVSTRWYRAPEVLL-----QSSLYTP-AVDMWAVGA-ILAELYA-LTPLFPGESEI---DQLYKICCVLGKPDWT-TFPEAKSISRIMS---------ISHTEFPQTRIAD---LLPN--AAPEAID-LINRLCSWDPLKRPTADEALN-------HPFF


PTK - `Conventional' protein-tyrosine kinases

Group I-IX Non-membrane spanning protein-tyrosine kinases
Group IX-XXI membrane spanning protein-tyrosine kinases


PTK group I

Src family


c-Src      LRLEVKLGQGCFGEVWMGTWNG---------------TTRVAIKTLKPGTM--------------SPEAFLQEAQVMKKL---------RHEKLVQLYAVVSE----------EPIYIVTEYMSK--GSLLDFLKGETGKY---------------------------LRLPQLVDMAAQIASGMAYVERM---------------NYVHRDLRAANILVGENL---------VCKVADFGLARLIEDN-----------EYTARQ--GAK--FPIKWTAPEAA------LYGRFTI-KSDVWSFGI-LLTELTTKGRVPYPG-------MVNREVLDQVERGYRMPCPPE----------------------------------------CPESLHD-LMCQCWRKEPEERPTFEYL---------QAFL
c-Yes      LRLEVKLGQGCFGEVWMGTWNG---------------TTKVAIKTLKPGTM--------------MPEAFLQEAQIMKKL---------RHDKLVPLYAVVSE----------EPIYIVTEFMSK--GSLLDFLKEGDGKY---------------------------LKLPQLVDMAAQIADGMAYIERM---------------NYIHRDLRAANILVGENL---------VCKIADFGLARLIEDN-----------EYTARQ--GAK--FPIKWTAPEAA------LYGRFTI-KSDVWSFGI-LQTELVTKGRVPYPG-------MVNREVLEQVERGYRMPCPQG----------------------------------------CPESLHE-LMNLCWKKDPDERPTFEYI---------QSFL
FYN        LQLIKRLGNGQFGEVWMGTWNG---------------NTKVAIKTLKPGTM--------------SPESFLEEAQIMKKL---------KHDKLVQLYAVVSE----------EPIYIVTEYMNK--GSLLDFLKDGEGRA---------------------------LKLPNLVDMAAQVAAGMAYIERM---------------NYIHRDLRSANILVGNGL---------ICKIADFGLARLIEDN-----------EYTARQ--GAK--FPIKWTAPEAA------LYGRFTI-KSDVWSFGI-LLTELVTKGRVPYPG-------MNNREVLEQVERGYRMPCPQD----------------------------------------CPISLHE-LMIHCWKKDPEERPTFEYL---------QSFL
YRK        LQLLQKLGNGQFGEVWMGTWNG---------------TTKVAVKTLKPGTM--------------SPEAFLEEAQIMKRL---------RHDKLVQLYAVVSE----------EPIYIVTEFMSQ--GSLLDFLKDGDGRY---------------------------LKLPQLVDMAAQIAAGMAYIERM---------------NYIHRDLRAANILVGDNL---------VCKIADFGLARLIEDN-----------EYTARQ--GAK--FPIKWTAPEAA------LFGKFTI-KSDVWSFGI-LLTELVTKGRVPYPG-------MNNREVLEQVERGYRMQCPGG----------------------------------------CPPSLHD-VMVQCWKREPEERPTFEYL---------QSFL
c-Fgr      ITLERRLGTGCFGDVWLGTWNG---------------STKVAVKTLKPGTM--------------SPKAFLEEAQVMKLL---------RHDKLVQLYAVVSE----------EPIYIVTEFMCH--GSLLDFLKNPEGQD---------------------------LRLPQLVDMAAQVAEGMAYMERM---------------NYIHRDLRAANILVGERL---------ACKIADFGLARLIKDD-----------EYNPCQ--GSK--FPIKWTAPEAA------LFGRFTI-KSDVWSFGI-LLTELITKGRIPYPG-------MNKREVLEQVEQGYHMPCPPG----------------------------------------CPASLYE-AMEQTWRLDPEERPTFEYL---------QSFL
LYN        IKLVKRLGAGQFGEVWMGYYNN---------------STKVAVKTLKPGTM--------------SVQAFLEEANLMKTL---------QHDKLVRLYAVVTRE---------EPIYIITEYMAK--GSLLDFLKSDEGGK---------------------------VLLPKLIDFSAQIAEGMAYIERK---------------NYIHRDLRAANVLVSESL---------MCKIADFGLARVIEDN-----------EYTARE--GAK--FPIKWTAPEAI------NFGCFTI-KSDVWSFGI-LLYEIVTYGKIPYPG-------RTNADVMTALSQGYRMPRVEN----------------------------------------CPDELYD-IMKMCWKEKAEERPTFDYL---------QSVL
HCK        LKLEKKLGAGQFGEVWMATYNK---------------HTKVAVKTMKPGSM--------------SVEAFLAEANVMKTL---------QHDKLVKLHAVVTK----------EPIYIITEFMAK--GSLLDFLKSDEGSK---------------------------QPLPKLIDFSAQIAEGMAFIEQR---------------NYIHRDLRAANILVSASL---------VCKIADFGLARVIEDN-----------EYTARE--GAK--FPIKWTAPEAI------NFGSFTI-KSDVWSFGI-LLMEIVTYGRIPYPG-------MSNPEVIRALERGYRMPRPEN----------------------------------------CPEELYN-IMMRCWKNRPEERPTFEYI---------QSVL
LCK        LKLVERLGAGQFGRCGWGTTTG---------------TTKVAVKSLKQGSM--------------SAGRLPAEANLMKQL---------QHQRLVRLYAVVTQ----------EPIYIITEYMEN--GSLVDFLKTPSGIK---------------------------LTINKLLDMAAQIAEGMAFIEER---------------NYIHRDLRAANILVSDTL---------SCKIADFGLARLIEDN-----------EYTARE--GAK--FPIKWTAPEAI------NYGTFTI-KSDVWSFGI-LLTEIVTHGRIPYPG-------MTNPEVIQNLERGYRMVRPDN----------------------------------------CPEELYQ-LMRLCWKERPEDRPTFDYL---------RSVL
BLK        LKLVRKLGSGQFGEVWMGYYKN---------------NMKVAIKTLKEGTM--------------SPEAFLGEANVMKTL---------QHERLVRLYAVVTR----------EPIYIVTEYMAR--GCLLDFLKTDEGSR---------------------------LSLPRLIDMSAQVAEGMAYIERM---------------NSIHRDLRAANILVSETL---------CCKIADFGLARII-DS-----------EYTAQE--GAK--FPIKWTAPEAI------HFGVFTI-KADVWSFGV-LLMVIVTYGRVPYPG-------MSNPEVIRSLEHGYRMPCPET----------------------------------------CPPELYNDIITECWRGRPEERPTFEFL---------QSVL
TorFYK     LQLIKKLGNGQFGEVWMGTWNG---------------TTKVAVKTLKPGTM--------------SPEAFLEEAQIMKRL---------RHDKLVQLYAVVSE----------EPIYIVTEFMTQ--GSLLDFLKDGDGRI---------------------------LKLPQLVDMAAQIAAGMAYIERM---------------NYIHRDLRAANILVGENL---------VCKIADFGLARLIEDN-----------EYTARQ--GAK--FPIKWTAPEAA------LYGKFTI-KSDVWSFGI-LLTELATKGRVPYPG-------MNNREVLEQVERGYRMPCPNA----------------------------------------CPVSLHE-LMIQCWKKDPEERHTFEYL---------QSFL
Dsrc64     IQLLRKLGRGNFGEVFYGKWRN---------------SIDVAVKTLREGTM--------------STAAFLQEAAIMKKF---------RHNRLVALYAVCSQE---------EPIYIVQEYMSK--GSLLDFLREGDGRY---------------------------LHFEDLIYIATQVASGMEYLESK---------------QLIHRDLAARNVLIGENN---------VAKICDFGLARVIADD-----------EYCPKQ--GSR--FPVKWTAPEAI------IYGKFSI-KSDVWSYGI-LLMELFTYGQVPYPG-------MHSREVIENIERGFRMPKPTNHY--------------------------------------FPDNIYQ-LLLQCWDAVPEKRPTFEFL---------NHYF
STK        LRLNRKLGAGQFGEVWAGVWNN---------------TTQVAVKTLKPGTM--------------SPASFLDEAGVMKKL---------RHKHLVQLTAICSDR---------EPIYIVTEYMSG--GSLLDYLSKGEGVN---------------------------LQLPTLIDMAAQVASGMAFLEAQ---------------GIYHRDLAARNILVGENY---------ICKVADFGLARLIEDD-----------EYTAHE--GAK--FPIKWTAPEAA------LYNRFTI-KADVWSFGV-LLMVIVTYGRVPYPG-------MTNAQTIAEVEKGYRMPIMPG----------------------------------------CPEPLYN-IMLQTWNKDPENRPTFDYL---------QGVL
SRK1       IKLLRRLGAGQFGEVWEGLWNG---------------TTSVAVKTLKPGTM--------------SVEEFLQEASIMKRL---------RHPKLIQLYAVCTKE---------EPIYIVTELMKY--GSLLEYLRGEDGV----------------------------LKIEQLVDYAAQVASGMSYLEQQ---------------NYIHRDLAARNILVGEHG---------ICKVADFGLARVIDEE-----------IYEAHT--GAK--FPIKWTAPEAA------MYNRFTI-KSDVWSFGV-VLYEIITYGRFPYPG-------MTWPEVLEKIQQNYRMPCPAN----------------------------------------CPKQFHD-IMLDCWREDPASRPTFETL---------QWQL
SRK2       ITLIRKLGAGQFGEVYQGLWNN---------------STPVAVKTLKAGTM--------------QPAAFLAEAQIMKKL---------RHPKLIQLYAVCTQG---------EPVYIITELMSK--GSLLDYLQGEAGA----------------------------LKLPQLIDMAAQVAAGMAYLELH---------------NYIHRDLAARNILVGDNN---------ICKVADFGLARLIVDD-----------DYNATE--GAK--FPIKWTAPEAA------LFNRFSI-KSDVWSFGI-LITELVTYGRIPYPG-------MSNAEVLQNLDKGYRMPCPVT----------------------------------------TPESLYQ-IMLDCWKRNPADRPTFEAL---------QWRL
SRK3       IQLQRKLGQGNFGEVWAGVWNG---------------TTAVAVKTLKPDTM--------------EVKDFVQEAQVMKKI---------HHPNLLQLYAVCTIG---------EPIYIVTELMKY--GSMLEYLKHGEDGKN--------------------------ITIHQMVDMSAQIASGMTYLEAH---------------SYIHRDLAARNILVGEGN---------VCKVADFGLARVIKED-----------IYNPRE--GTK--FPIKWTAPEAA------LYNRFTI-KSDVWSFGV-LISEIVTHGRMPYPG-------MTNRQVLEAVDRGYRMPCPEG----------------------------------------CPDPLYK-IMLSCWKHEPDDRPTFESL---------KNLL
SRK4       IKLLRGLGAGQFGEVWEGLWNG---------------TTSVAVKTLKPGTM--------------SIEEFLEEASIMKRL---------RHPKLIQLYAVCTKE---------EPIYIVTELMKH--GSLLEYLRGEDGRS---------------------------LKLPDLVDMCSQVATGMSYLEQQ---------------NYIHRDLAARNILVGEHK---------ICKVADFGLARVIDEE-----------IYEAKL--GAK--FPIKWTAPEAA------MYSRFTI-KSDVWSFGI-VLYEVITYGRFPYPG-------MTNAQVLEQIQQSYRMPRPMG----------------------------------------CPEKLYA-IMMDCWREDPASRPTFETL---------SWQL

PTK Group II

Tec/Atk family


Tec        LTFMRELGSGLFGVVRLGKWRA---------------QYKVAIKAIREGAM--------------CEEDFIEEAKVMMKL---------THPKLVQLYGVCTQQ---------KPIYIVTEFMER--GCLLNFLRQRQGH----------------------------FSRDMLLSMCQDVCEGMEYLERN---------------SFIHRDLAARNCLVNEAG---------VVKVSDFGMARYVLDD-----------QYTSSS--GAK--FPVKWCPPEVF------NYSRFSS-KSDVWSFGV-LMWEIFTEGRMPFEK-------NTNYEVVTMVTRGHRLHDPKL----------------------------------------ATKYLYE-VMLRCWQERPEGRPSFEDL---------LRTI
Itk/Tsk    LTFVQEIGSGQFGLVHLGYWLN---------------KDKVAIKTIQEGAM--------------SEEDFIEEAEVMMKL---------SHPKLVQLYGVCLEQ---------APICLVFEFMEH--GCLSDYLRSQRGL----------------------------FAAETLLGMCLDVCEGMAYLEKA---------------CVIHRDLAARNCLVGENQ---------VIKVSDFGMTRFVLDD-----------QYTSST--GTK--FPVKWASPEVF------SFSRYSS-KSDVWSFGV-LMWEVFSEGKIPYEN-------RSNSEVVEDISTGFRLYKPRL----------------------------------------ASCHVYQ-IMNHCWKEKPEDRPPFSQL---------LSQL
Btk        LTFLKELGTGQFGVVKYGKWRG---------------QYDVAIKMIKEGSM--------------SEDEFIEEAKVMMNL---------SHEKLVQLYGVCTKQ---------RPIFIITEYMAN--GCLLNYLREMRHR----------------------------FQTQQLLEMCKDVCEAMEYLESK---------------QFLHRDLAARNCLVNDQG---------VVKVSDFGLSRYVLDD-----------EYTSSV--GSK--FPVRWSPPEVL------MYSKFSS-KSDIWAFGV-LMWEIYSLGKMPYER-------FTNSETAEHIAQGLRLYRPHL----------------------------------------ASEKVYT-IMYSCWHEKADERPTKKIL---------LSNI
Dsrc28     LMLMEELGSGQFGVVRRGKWRG---------------SIDTAVKMMKEGTM--------------SEDDFIEEAKVMTKL---------QHPNLVQLYGVCTKH---------RPIYIVTEYMKH--GSLLNYLRRHEKTLI--------------------------GNMGLLLDMCIQVSKGMTYLERH---------------NYIHRDLAARNCLVGSEN---------VVKVADFGLARYVLDD-----------QYTSSG--GTK--FPIKWAPPEVL------NYTRFSS-KSDVWAYGV-LMWEIFTCGKMPYGR-------LKNTEVVERVQRGIILEKPKS----------------------------------------CAKEIYD-VMKLCWSHGPEERPAFRVL---------MDQL

DtSpk-1    IEILNEIGRGFFGSVHRAKWGR---------------SYEVAAKMLQSSKA--------------EREKFVLEAKIMHKL---------RHRKIVELLGVCTEPQD-------MPMLIIVEYMKN--GSLKEYLKTPDGKK---------------------------TNLNQMVHMMAEISEGMAYLESE---------------KVVHRDLRADNILVANDL---------TRKVADFGLTELTDGS-----------LGDQEKK-TLR--FPYKWTAPEAA------KSKVFTS-KSDVWSYGI-VMFEILTWASSPYPD-------IPAKEVIEKVSKGYRMPNPEKFITGVC----------------------------------CPDEIYK-IMIWCWDANPEKRPTFLVL---------QEKM

PTK Group III

Csk family


Csk        LKLLQTIGKGEFGDVMLGDYRG----------------NKVAVKCIKNDA---------------TAQAFLAEASVMTQL---------RHSNLVQLLGVIVEEK--------GGLYIVTEYMAK--GSLVDYLRSRGRSV---------------------------LGGDCLLKFSLDVCEAMEYLEGN---------------NFVHRDLAARNVLVSEDN---------VAKVSDFGLTKEASST-----------QDT------GK--LPVKWTAPEAL------REKKFST-KSDVWSFGI-LLWEIYSFGRVPYPR-------IPLKDVVPRVEKGYKMDAPDG----------------------------------------CPPAVYE-VMKNCWHLDAAMRPSFLQL---------REQL
Matk       LTLGAQIGEGEFGAVLQGEYLG----------------QKVAVKNIKCDV---------------TAQAFLDETAVMTKM---------QHENLVRLLGVILH----------QGLYIVMEHVSK--GNLVNFLRTRGRAL---------------------------VNTAQLLQFSLHVAEGMEYLESK---------------KLVHRDLAARNILVSEDL---------VAKVSDFGLAKAERKG-----------LDS------SR--LPVKWTAPEAL------KHG-FTS-KSDVWSFGV-LLWEVFSYGRAPYPK-------MSLKEVSEAVEKGYRMEPPEG----------------------------------------CPGPVHV-LMSSCWEAEPPAGHPSANW---------PRSW

PTK Group IV

Fes (Fps) family


c-Fes      LVLGEQIGRGNFGEVFSGRLRAD--------------NTLVAVKSCRETLPPD------------IKAKFLQEAKILKQY---------SHPNIVRLIGVCTQK---------QPIYIVMELVQG--GDFLTFLRTEGAR----------------------------LRVKTLLQMVGDAAAGMEYLESK---------------CCIHRDLAARNCLVTEKN---------VLKISDFGMSREEADG-----------VYAASG--GLRQ-VPVKWTAPEAL------NYGRYSS-ESDVWSFGI-LLWETFSLGASPYPN-------LSNQQTREFVEKGGRLPCPEL----------------------------------------CPDAVFR-LMEQCWAYEPGQRPSFSTI---------YQEL
FER        VILGELLGKGNFGEVYKGTLKD---------------KTSVAVKTCKEDLPQE------------LKIKFLQEAKILKQY---------DHPNIVKLIGVCTQR---------QPVYIIMELVSG--GDFLTFLRRKKDE----------------------------LKLKQLVKFSLDAAAGMLYLESK---------------NCIHRDLAARNCLVGENN---------VLKISDFGMSRQEDGG-----------VYSSS---GLKQ-IPIKWTAPEAL------NYGRYSS-ESDVWSFGI-LLWETFSLGVCPYPG-------MTNQQAREQVERGYRMSAPQH----------------------------------------CPEDISK-IMMKCWDYKPENRPKFSEL---------QKEL
Dfps       VVLLERIGRGNFGDVYKAKLKST--------------KLDVAVKTCRMTLPDE------------QKRKFLQEGRILKQY---------DHPNIVKLIGICVQK---------QPIMIVMELVLG--GSLTLYLRKNSNG----------------------------LTTREQMGMCRDAAAGMRYLESK---------------NCIHRDLAARNCLVDLEH---------SVKISDFGMSREEEE-------------YIVSD--GMKQ-IPVQWTAPEAL------NFGKYTS-LCDVWSYGI-LMWEIFSKGDTPYSG-------MTNSRARERIDTGYRMPTPKS----------------------------------------TPEEMYR-LMLQCWAADAESRPHFDEI---------YNVV

PTK Group V

Abl family


c-Abl      ITMKHKLGGGQYGEVYEGVWKKY--------------SLTVAVKTLKEDTM--------------EVEEFLKEAAVMKEI---------KHPNLVQLLGVCTRE---------PPFYIITEFMTY--GNLLDYLRECNRQE---------------------------VNAVVLLYMATQISSAMEYLEKK---------------NFIHRDLAARNCLVGENH---------LVKVADFGLSRLMTGD-----------TYTAHA--GAK--FPIKWTAPESL------AYNKFSI-KSDVWAFGV-LLWEIATYGMSPYPG-------IDPSQVYELLEKDYRMERPEG----------------------------------------CPEKVYE-LMRACWQWNPSDRPSFAEI---------HQAF
ARG        ITMKHKLGGGQYGEVYVGVWKKY--------------SLTVAVKTLKEDTM--------------EVEEFLKEAAVMKEI---------KHPNLVQLLGVCTLE---------PPFYIVTEYMPY--GNLLDYLRECNREE---------------------------VTAVVLLYMATQISSAMEYLEKK---------------NFIHRDLAARNCLVGENH---------VVKVADFGLSRLMTGD-----------TYTAHA--GAK--FPIKWTAPESL------AYNTFSI-KSDVWAFGV-LLWEIATYGMSPYPG-------IDLSQVYDLLEKGYRMEQPEG----------------------------------------CPPKVYE-LMRACWKWSPADRPSFAET---------HQAF
Dabl       IMMKHKLGGGQYGEVYEAVWKRY--------------GNTVAVKTLKEDTM--------------ALKDFLEEAAIMKEM---------KHPNLVQLIGVCTRE---------PPFYIITEFMSH--GNLLDFLRSAGRET---------------------------LDAVALLYMATQIASGMSYLESR---------------NYIHRDLAARNCLVGDNK---------LVKVADFGLARLMRDD-----------TYTAHA--GAK--FPIKWTAPEGL------AYNKFST-KSDVWAFGV-LLWEIATYGMSPYPA-------IDLTDVYHKLDKGYRMERPPG----------------------------------------CPPEVYD-LMRQCWQWDATDRPTFKSI---------HHAL
Nabl       IIMHNKLGGGQYGDVYEGYWKRH--------------DCTIAVKALKEDAM--------------PLHEFLAEAAIMKDL---------HHKNLVRLLGVCTHE---------APFYIITEFMCN--GNLLEYLRRTDKSL---------------------------LPPIILVQMASQIASGMSYLEAR---------------HFIHRDLAARNCLVSEHN---------IVKIADFGLARFMKED-----------TYTAHA--GAK--FPIKWTAPEGL------AFNTFSS-KSDVWAFGV-LLWEIATYGMAPYPG-------VELSNVYGLLENGFRMDGPQG----------------------------------------CPPSVYR-LMLQCWNWSPSDRPRFRDI---------HFNL

PTK Group VI

Syk/ZAP70 family


Syk2       TLEDKELGSGNFGTVKKGYYQMKKV------------VKTVAVKILKNEANDPA-----------LKDELLAEANVMQQL---------DNPYIVRMIGICEA----------ESWMLVMEMAEL--GPLNKYLQQNRH-----------------------------VKDKNIIELVHQVSMGMKYLEEC---------------NFVHRDLAARNVLLVTQH---------YAKISDFGLSKALRAD---------ENYYKAQT--HGK--WPVKWYAPECI------NYYKFSS-KSDVWSFGV-LMWEAFSYGQKPYRG-------MKGSEVSAMLEKGERMGCPPG----------------------------------------CPREMYE-LMTLCWTYDVENRPGFVAV---------ELRL
ZAP70      LIADIELGCGNFGSVRQGVYRMRKK------------QIDVAIKVLKQGTEKA------------DTEEMMREAQIMEQL---------DNPYIVRLIGVCQA----------EALMLVMEMAGG--GPLHKFL-VGKREE---------------------------IPVSNVAELLHQVSMGMKYLEEK---------------NFVHRDLAARNVLLVNRH---------YAKISDFGLSKALGAD---------DSYYTARS--AGK--WPLKWYAPECI------NFRKFSS-RSDVWSYGV-TMWEALSYGQKPYKK-------MKGPEVMAFIEQGKRMECPPE----------------------------------------CPPELYA-LMSDCWIYKWEDRPDFLTV---------EQRM
Htk16      ISFGKELGVGEFGSVIKGIWLSPGGK-----------EINVAMKTLHKDKMVQ------------GEKEFLREALVMSQL---------NHPCIVSLLGVCLG----------PPMILVQELVEM--GALLDYLMDYQPE----------------------------IQEVDLKLWASQIAFGMMYLELK---------------RFVHRDLAARNILLANKK---------QVKISDFGLSRAVGTG---------SDYYQAKQ--GGR--WPVRWYAPESI------NYGTFST-KSDVWSYGI-TLWEMFTFGDLPYGE-------MTGNEVVSFLEHCGRLEKPDE----------------------------------------CPIHTYS-IMLSCWHIDPNKRPTFNEL---------HSTF

PTK Group VII

Tyk2/Jak1 family


TYK2       LKKIRDLGEGHFGKVSLYCYDPTNDG----------TGEMVAVKALKADCGPQ------------HRSGWKQEIDILRTL---------YHEHIIKYKGCCEDQGE-------KSLQLVMEYVPL--GSLRDYLPRHS------------------------------IGLAQLLLFAQQICEGMAYLHAH---------------DYIHRDLAARNVLLDNDR---------LVKIGDFGLAKAVPEG---------HEYYRVRE--DGD--SPVFWYAPECL------KEYKFYY-ASDVWSFGV-TLYELLTHCDSSQSPPTK{11}MTVLRLTELLERGERLPRPDK----------------------------------------CPCEVYH-LMKNCWETEASFRPTFENL---------IPIL
JAK1       LKRIRDLGEGHFGKVELCRYDPE-DN----------TGEQVAVKSLKPESGGN------------HIADLKKEIEILRNL---------YHENIVKYKGICTEDGG-------NGIKLIMEFLPS--GSLKEYLPKNKNK----------------------------INLKQQLKYAVQICKGMDYLGSR---------------QYVHRDLAARNVLVESEH---------QVKIGDFGLTKAIETD---------KEYYTVKD--DRD--SPVFWYAPECL------MQSKFYI-ASDVWSFGV-TLHELLTYCDSDSSPMAL{11}MTVTRLVNTLKEGKRLPCPPN----------------------------------------CPDEVYQ-LMRKCWEFQPSNRTSFQNL---------IEGF
JAK2       LKFLQQLGKGNFGSVEMCRYDPLQDN----------TGEVVAVKKLQHSTEE-------------HLRDFEREIEILKSL---------QHDNIVKYKGVCYSAGR-------RNLRLIMEYLPY--GSLRDYLQKHKER----------------------------IDHKKLLQYTSQICKGMEYLGTK---------------RYIHRDLATRNILVENEN---------RVKIGDFGLTKVLPQD---------KEYYKVKE--PGE--SPIFWYAPESL------TESKFSV-ASDVWSFGV-VLYELFTYIEKSKSPPVE{12}MIVFHLIELLKSNGRLPRPEG----------------------------------------CPDEIYV-IMTECWNNNVSQRPSFRDL---------SFGW
HOP        YNMENMIGRGHYGTVYKGHLEFNDKDQ---------PREQVAIKMLNTMQ---------------VSTDFHREIGIMRTL---------SHPNIVKFKYWAE-----------KSHCIIMEYLQS--GSFDIYLRFTAPN----------------------------LNNPRLVSFALDIANGMKYLSDM---------------GLIHRDLAARNILVDHNGDGD------CVKISDFGLAQFANSD----------GYYYAKS--KRD--IPIRWYSPEAI------STCRFSS-YSDVWSYGV-TLFEMFSRGEEPNLVPIQ----TSQEDFLNRLQSGERLNRPAS----------------------------------------CPDFIYD-LMQLCWHATPRSRPSFATI---------VDII

PTK Group VIII

Ack family


ACK        LRLLEKLGDGSFGVVRRGEWDAPSG-----------KTVSVAVKCLKPDVLSQPE----------AMDDFIREVNAMHSL---------DHRNLIRLYGVVLT----------PPMKMVTELAPL--GSLLDRLRKHQGH----------------------------FLLGTLSRYAVQVAEGMGYLESK---------------RFIHRDLAARNLLLATRD---------LVKIGDFGLMRALPQN---------DDHYVMQE--HRK--VPFAWCAPESL------KTRTFSH-ASDTWMFGV-TLWEMFTYGQEPWIGL------NGSQILHKIDKEGERLPRPED----------------------------------------CPQDIYN-VMVQCWAHKPEDRPTFVAL---------RDFL

PTK Group IX

Focal adhesion kinase family


FAK        IELGRCIGEGQFGDVHQGVYLSPEN-----------PALAVAIKTCKNCTSDS------------VREKFLQEALTMRQF---------DHPHIVKLIGVITE----------NPVWIIMELCTL--GELRSFLQVRKYS----------------------------LDLASLILYAYQLSTALAYLESK---------------RFVHRDIAARNVLVSSND---------CVKLGDFGLSRYMED----------STYYKAS---KGK--LPIKWMAPESI------NFRRFTS-ASDVWMFGV-CMWEILMHGVKPFQG-------VKNNDVIGRIENGERLPMPPN----------------------------------------CPPTLYS-LMTKCWAYDPSRRPRFTEL---------KAQL

PTK Group X

Epidermal growth factor receptor family


EGFR       FKKIKVLGSGAFGTVYKGLWIPEGEK----------VKIPVAIKELREATSPK------------ANKEILDEAYVMASV---------DNPHVCRLLGICLT----------STVQLITQLMPF--GCLLDYVREHKDN----------------------------IGSQYLLNWCVQIAKGMNYLEDR---------------RLVHRDLAARNVLVKTPQ---------HVKITDFGLAKLLGAE---------EKEYHAE---GGK--VPIKWMALESI------LHRIYTH-QSDVWSYGV-TVWELMTFGSKPYDG-------IPASEISSILEKGERLPQPPI----------------------------------------CTIDVYM-IMVKCWMIDADSRPKFREL---------IIEF
ErbB2      LRKVKVLGSGAFGTVYKGIWIPDGEN----------VKIPVAIKVLRENTSPK------------ANKEILDEAYVMAGV---------GSPYVSRLLGICLT----------STVQLVTQLMPY--GCLLDHVRENRGR----------------------------LGSQDLLNWCMQIAKGMSYLEDV---------------RLVHRDLAARNVLVKSPN---------HVKITDFGLARLLDID---------ETEYHAD---GGK--VPIKWMALESI------LRRRFTH-QSDVWSYGV-TVWELMTFGAKPYDG-------IPAREIPDLLEKGERLPQPPI----------------------------------------CTIDVYM-IMVKCWMIDSECRPRFREL---------VSEF
ErbB3      LRKLKVLGSGVFGTVHKGVWIPEGES----------IKIPVCIKVIEDKSGRQ------------SFQAVTDHMLAIGSL---------DHAHIVRLLGLCPG----------SSLQLVTQYLPL--GSLLDHVRQHRGA----------------------------LGPQLLLNWGVQIAKGMYYLEEH---------------GMVHRNLAARNVLLKSPS---------QVQVADFGVADLLPPD---------DKQLLYS---EAK--TPIKWMALESI------HFGKYTH-QSDVWSYGV-TVWELMTFGAEPYAG-------LRLAEVPDLLEKGERLAQPQI----------------------------------------CTIDVYM-VMVKCWMIDENIRPTFKEL---------ANEF
ErbB4      LKRVKVLGSGAFGTVYKGIWVPEGET----------VKIPVAIKILNETTGPK------------ANVEFMDEALIMASM---------DHPHLVRLLGVCLS----------PTIQLVTQLMPH--GCLLEYVHEHKDN----------------------------IGSQLLLNWCVQIAKGMMYLEER---------------RLVHRDLAARNVLVKSPN---------HVKITDFGLARLLEGD---------EKEYNAD---GGK--MPIKWMALECI------HYRKFTH-QSDVWSYGV-TIWELMTFGGKPYDG-------IPTREIPDLLEKGERLPQPPI----------------------------------------CTIDVYM-VMVKCWMIDADSRPKFKEL---------AAEF
DER        LRKGGVLGMGAFGRVYKGVWVPEGEN----------VKIPVAIKELLKSTGAE------------SSEEFLREAYIMASE---------EHVNLLKLLAVCMS----------SQMMLITQLMPL--GCLLDYVRNNRDK----------------------------IGSKALLNWSTQIAKGMSYLEEK---------------RLVHRDLAARNVLVRLL----------AGEDHDFGLAKLLSSD---------SNEYKAA---GGK--MPIKWLALECI------RNRVFTS-KSDVWAFGV-TIWELLTFGQRPHEN-------IPAKDIPDLIEVGLKLEQPEI----------------------------------------CSLDIYC-TLLSCWHLDAAMRPTFKQL---------TTVF
let-23     TKLDKKLGAGAFGTVFAGIYYPKRAKN---------VKIPVAIKVFQTDQS--------------QTDEMLEEATNMFRL---------RHDNLLKIIGFCMH----------DDGLKIVTIYRPL-GNLQNFLKLHKEN----------------------------LGAREQVLYCYQIASGMQYLEKQ---------------RVVHRDLATRNVLVKKFN---------HVEITDFGLSKILKHD---------ADSITIK---SGK--VAIKWLAIEIF------SKHCYTH-ASDVWAFGV-TCWEIITFGQSPYQG-------MSTDSIHNFLKDGNRLSQPPN----------------------------------------CSQDLYQ-ELLRCWMADPKSRPGFEIL---------YERF
SER        DFNSAPLGTGSFGAVYKGVWKVPKHALLRYNWHRG-AQLDVAIKVILNDSPECSVTANPSS{21}NIEELLQEAKIMASV---------MHRHCLPLIGICLSS---------ERHCLVSIFVEL--GALDRYVKQHADE----------------------------LNSLTLLSWAEQIADGMSYLEMR---------------GIIHRDLAARNVLVQTRE---------HVQITDFGLAKMLERRD--------EDSVIVK---AGR--VPIRWLAIETL------QYGIYSH-KTDVWSYGV-TLWEIFTFGKRPYED-------VDTVDIKDHVIKGGRLTQPDI----------------------------------------CTLDVYM-VLVKCWMEDYESRPTFIEL---------MRTF

PTK Group XI

Eph/Elk/Eck orphan receptor family


ECK        VTRQKVIGAGEFGEVYKGMLKTSSGK----------KEVPVAIKTLKAGYTEK------------QRVDFLGEAGIMGQF---------SHHNIIRLEGVISKY---------KPMMIITEYMEN--GALDKFLREKDGE----------------------------FSVLQLVGMLRGIAAGMKYLANM---------------NYVHRDLAARNILVNSNL---------VCKVSDFGLSRVLEDD--------PEATYTTS---GGK--IPIRWTAPEAI------SYRKFTS-ASDVWSFGI-VMWEVMTYGERPYWE-------LSNHEVMKAINDGFRLPTPMD----------------------------------------CPSAIYQ-LMMQCWQQERARRPKFADI---------VSIL
EEK        IHIEKIIGSGESGEVCYGRLQVPGQ-----------RDVPVAIKALKAGYTER------------QRQDFLREAAIMGQF---------DHPNIIRLEGVVTRG---------RLAMIVTEYMEN--GSLDAFLRTHDGQ----------------------------FTILQLVGMLKGVGAGMRYLSDL---------------GYIHRDLAARNILVDGRL---------VCKVSDFGLSRALEDD--------PEAAYTTA---GGK--IPIRWTAPEAI------AFRTFSS-ASDVWSFGV-VMWEVLAYGERPYWN-------MTNQDVISSVEEGYRLPAPMG----------------------------------------CPRALHQ-LMLDCWHKDRAQRPRFSHV---------VSVL
HEK        ISIDKVVGAGEFGEVCSGRLKLPSK-----------KEISVAIKTLKVGYTEK------------QRRDFLGEASIMGQF---------DHPNIIRLEGVVTKS---------KPVMIVTEYMEN--GSLDSFLRKHDAQ----------------------------FTVIQLVGMLRGIASGMKYLSDM---------------GYVHRDLAARNILINSNL---------VCKVSDFGLSRVLEDD--------PEAAYTTR---GGK--IPIRWTSPEAI------AYRKFTS-ASDVWSYGI-VLWEVMSYGERPYWE-------MSNQDVIKAVDEGYRLPPPMD----------------------------------------CPAALYQ-LMLDCWQKDRNNRPKFEQI---------VSIL
Ehk-1      ITIERVIGAGEFGEVCSGCLKLPGK-----------RELPVAIKTLKVGYTEK------------QRRDFLGEASIMGQF---------DHPNIIHLEGVVTKS---------KPVMIVTEYMEN--GSLDTFLKKNDGQ----------------------------FTVIQLVGMLRGIAAGMKYLSDM---------------GYVHRDLAARNILINSNL---------VCKVSDFGLSRVLEDD--------PEAAYTTR---GGK--IPIRWTAPEAI------AFRKFTS-ASDVWSYGI-VMWEVVSYGERPYWE-------MTNQDVIKAVEEGYRLPSPMD----------------------------------------CPAALYQ-LMLDCWQKDRNSRPKFDEI---------VNML
Ehk-2      IRIERVIGAGEFGEVCSGRLKTPGK-----------REIPVAIKTLKGGHMDR------------QRRDFLREASIMGQF---------DHPNIIRLEGVVTKRSFPAI{37}RPVMIVVEYMEN--GSLDSFLRKHDGH----------------------------FTVIQLVGMLRGIASGMKYLSDM---------------GYVHRDLAARNILVNSNL---------VCKVSDFGLSRVLEDD--------PEAAYTTT---GGK--IPIRWTAPEAI------AYRKFSS-ASDVWSYGI-VMWEVMSYGERPYWE-------MSNQDVILSIEEGYRLPAPMG----------------------------------------CPPSLHQ-LMLHCWQKERNHRPKFTDI---------VSFL
SEK        IKIEKVIGVGEFGEVCSGRLKVPGK-----------REICVAIKTLKAGYTDK------------QRRDFLSEASIMGQF---------DHPNIIHLEGVVTKC---------KPVMIITEYMEN--GSLDAFLRKNDGR----------------------------FTVIQLVGMLRGIGSGMKYLSDM---------------SYVHRDLAARNILVNSNL---------VCKVSDFGMSRVLEDD--------PEAAYTTR---GGK--IPIRWTAPEAI------AYRKFTS-ASDVWSYGI-VMWEVMSYGERPYWD-------MSNQDVIKAIEEGYRLPPPMD----------------------------------------CPIALHQ-LMLDCWQKERSDRPKFGQI---------VNML
ELK        VKIEEVIGAGEFGEVYKGRLKLPGK-----------REIYVAIKTLKAGYSEK------------QRRDFLSEASIMGQF---------DHPNIIRLEGVVTKS---------RPVMIITEFMEN--GALDSFLRQNDGQ----------------------------FTVIQLVGMLRGIAAGMKYLSEM---------------NYVHRDLAARNILVNSNL---------VCKVSDFGLSRYLQDD-------TSDPTYTSSL--GGK--IPVRWTAPEAI------AYRKFTS-ASDVWSYGI-VMWEVMSFGERPYWD-------MSNQDVINAIEQDYRLPPPMD----------------------------------------CPAALHQ-LMLDCWQKDRNSRPRFAEI---------VNTL
Cek10      VKIEEVIGAGEFGEVCRGRLKLPGR-----------REIFVAIKTLKVGYTER------------QRRDFLSEASIMGQF---------DHPNIIHLEGVVTKS---------RPVMIITEFMEN--CALDSFLRLNDGQ----------------------------FTVIQLVGMLRGIAAGMKYLSEM---------------NYVHRDLAARNILVNSNL---------VCKVSDFGLSRFLEDD-------PADPTYTSSL--GGK--IPIRWTAPEAI------AYRKFTS-ASDVWSYGI-VMWEVMSYGERPYWD-------MSNQDVINAVEQDYRLPPPMD----------------------------------------CPTALHQ-LMLDCWVRDRNLRPKFAQI---------VNTL
Cek9       IKIEEVIGSGEFGEVCFGRLKHPGK-----------REYTVAIKTLKSGYTDE------------QRREFLSEASIMGQF---------EHPNVIHLEGVVTKS---------RPVMIVTEFMEN--GSLDSFLREKEGQ----------------------------FSVLQLVGMLRGIAAGMRYLSDM---------------NYVHRDLAARNILVNSNL---------VCKVSDFGLSRFLEDD-------ASNPTYTGAL--GCK--IPIRWTAPEAV------QYRKFTS-SSDVWSYGI-VMWEVMSYGERPYWD-------MSNQDVINAIDQDYRLPPPPD----------------------------------------CPTVLHL-LMLDCWQKDRVQRPKFEQI---------VSAL
HEK2       VKIEEVIGAGEFGEVCRGRLKQPGR-----------REVFVAIKTLKVGYTER------------QRRDFLSEASIMGQF---------DHPNIIRLEGVVTKS---------RPVMILTEFMEN--CALDSFLRLNDGQ----------------------------FTVIQLVGMLRGIAAGMKYLSEM---------------NYVHRDLAARNILVNSNL---------VCKVSDFGLSRFLEDD-------PSDPTYTSSL--GGK--IPIRWTAPEAI------AYRKFTS-ASDVWSYGI-VMWEVMSYGERPYWD-------MSNQDVINAVEQDYRLPPPMD----------------------------------------CPTALHQ-LMLDCWVRDRNLRPKFSQI---------VNTL
Nuk        VKIEQVIGAGEFGEVCSGHLKLPGK-----------REIFVAIKTLKSGYTEK------------QRRDFLSEASIMGQF---------DHPNVIHLEGVVTKS---------TPVMIITEFMEN--GSLDSFLRQNDGQ----------------------------FTVIQLVGMLRGIAAGMKYLADM---------------NYVHRDLAARNILVNSNL---------VCKVSDFGLSRFLEDD-------TSDPTYTSAL--GGK--IPIRWTAPEAI------QYRKFTS-ASDVWSYGI-VMWEVMSYGERPYWD-------MTNQDVINAIEQDYRLPPPMD----------------------------------------CPSALHQ-LMLDCWQKDRNHRPKFGQI---------VNTL
EPH        LMVDTVIGEGEFGEVYRGTLRLPSQ-----------DCKTVAIKTLKDTSPGG------------QWWNFLREATIMGQF---------SHPHILHLEGVVTKR---------KPIMIITEFMEN--GALDAFLREREDQ----------------------------LVPGQLVAMLQGIASGMNYLSNH---------------NYVHRDLAARNILVNQNL---------CCKVSDFGLTRLLDDF---------DGTYETQ---GGK--IPIRWTAPEAI------AHRIFTT-ASDVWSFGI-VMWEVLSFGDKPYGE-------MSNQEVMKSIEDGYRLPPPVD----------------------------------------CPAPLYE-LMKNCWAYDRARRPHFQKL---------QAHL

PTK Group XII

Axl family


Axl        VALGKTLGEGEFGAVMEGQLNQDD------------SILKVAVKTMKIAICTRS-----------ELEDFLSEAVCMKEF---------DHPNVMRLIGVCFQGSERESF---PAPVVILPFMKH--GDLHSFLLYSRLGDQPVY-----------------------LPTQMLVKFMADIASGMEYLSTK---------------RFIHRDLAARNCMLNENM---------SVCVADFGLSKKIYNG----------DYYRQGR--IAK--MPVKWIAIESL------ADRVYTS-KSDVWSFGV-TMWEIATRGQTPYPG-------VENSEIYDYLRQGNRLKQPAD----------------------------------------CLDGLYA-LMSRCWELNPQDRPSFTEL---------REDL
Ark        VALGKTLGEGEFGAVMEGQLNQDD------------SILKVAVKTMKIVICTRS-----------ELEDFLSEAVCMKEF---------DHPNVMRLIGVCFQGSDREGF---PEPVVILPFMKH--GDLHSFLLYSRLGDQPVF-----------------------LPTQMLVKFMADIASGMEYLSTK---------------RFIHRDLAARNCMLNENM---------SVCVADFGLSKKIYNG----------DYYAKGR--IAK--MPVKWIAIESL------ADRVYTS-KSDVWLFGV-TMWEIATRGQTPYPG-------VENSEIYDYLRKGNRLKQPVD----------------------------------------CLDGLYA-LMSRCWELNPRDRPSFAEL---------REDL
c-Eyk      LSLGKVLGEGEFGSVMEGRLSQPEG-----------TPQKVAVKTMKLDNFSHR-----------EIEEFLSEAACMKDF---------DHPNVIKLLGVCIELSSQQI----PKPMVVLPFMKY--GDLHSFLLRSRLEMAPQF-----------------------VPLQMLLKFMVDIALGMEYLSSR---------------QFLHRDLAARNCMLRDDM---------TVCVADFGLSKKIYSG----------DYYRQGR--IAK--MPVKWIAIESL------ADRVYTT-KSDVWAFGV-TMWEIATRGMTPYPG-------VQNHEIYEYLFHGQRLKKPEN----------------------------------------CLDELYD-IMSSCWRAEPADRPTFSQL---------KVHL
Brt/Sky    FTLGRMLGKGEFGSVREAQLKQEDG-----------SFVKVAVKMLKADIIASS-----------DIEEFLREAACMKEF---------DHPHVAKLVGVSLRSRAKGRL---PIPMVILPFMKH--GDLHAFLLASRIGENPFN-----------------------LPLQTLIRFMVDIACGMEYLSSR---------------NFIHRDLAARNCMLAEDM---------TVCVADFGLSRKIYSG----------DYYRQGC--ASK--LPVKWLALESL------ADNLYTV-QSDVWAFGV-TMWEIMTRGQTPYAG-------IENAEIYNYLIGGNRLKQPPE----------------------------------------CMEDVYD-LMYQCWSADPKQRPSFTCL---------RMEL

PTK Group XIII

Tie/Tck family


Tie        ITFEDLIGEGNFGQVIRAMIKKDG------------LKMNAAIKMLKEYASEN------------DHRDFAGELEVLCKLG--------HHPNIINLLGACKNR---------GYLYIAIEYAPY--GNLLDFLRKSRVLETDPAFAREHGTAST-------------LSSRQLLRFASDAANGMQYLESK---------------QFIHRDLAARNVLVGENL---------ASKIADFGLSRGE-------------EVYVKKT--MGR--LPVRWMAIESL------NYSVYTT-KSDVWSFGV-LLWEIVSLGGTPYCG-------MTCAELYEKLPQADRMEQPRN----------------------------------------CDDEVYE-LMRQCWRDRPYERPPFAQI---------ALQL
Tek        IKFQDVIGEGNFGQVLKARIKKDG------------LRMDAAIKRMKEYASKD------------DHRDFAGELEVLCKLG--------HHPNIINLLGACEHR---------GYLYLAIEYAPH--GNLLDFLRKSRVLETDPAFAIANSTAST-------------LSSQQLLHFAADVARGMDYLSQK---------------QFIHRDLAARNILVGENY---------VAKIADFGLSRGQ-------------EVYVKKT--MGR--LPVRWMAIESL------NYSVYTT-NSDVWSYGV-LLWEIVSLGGTPYCG-------MTCAELYEKLPQGYRLEKPLN----------------------------------------CDDEVYD-LMRQCWREKPYERPSFAQI---------LVSL

PTK Group XIV

Platelet-derived growth factor receptor family


PDGFR-b    LVLGRTLGSGAFGQVVEATAHGLSHSQ---------ATMKVAVKMLKSTARSS------------EKQALMSELKIMSHLG--------PHLNVVNLLGACTKG---------GPIYIITEYCRY--GDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVG{74}LSYMDLVGFSYQVANGMEFLASK---------------NCVHRDLAARNVLICEGK---------LVKICDFGLARDIMRD----------SNYISKG--STF--LPLKWMAPESI------FNSLYTT-LSDVWSFGI-LLWEIFTLGGTPYPEL------PMNEQFYNAIKRGYRMAQPAH----------------------------------------ASDEIYE-IMQKCWEEKFEIRPPFSQL---------VLLL
PDGFR-a    LVLGRVLGSGAFGKVVEGTAYGLSRSQ---------PVMKVAVKMLKPTARSS------------EKQALMSELKIMTHLG--------PHLNIVNLLGACTKS---------GPIYIITEYCFY--GDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADES{73}LTLLDLLSFTYQVARGMEFLASK---------------NCVHRDLAARNVLLAQGK---------IVKICDFGLARDIMHD----------SNYVSKG--STF--LPVKWMAPESI------FDNLYTT-LSDVWSFGI-LLWEIFSLGGTPYPGM------MVDSTFYNKIKSGYRMAKPDH----------------------------------------ATSEVYE-IMVKCWNSEPEKRPSFYHL---------SEIV
CSF1R      LQFGKTLGAGAFGKVVEATAFGLGKED---------AVLKVAVKMLKSTAHAD------------EKEALMSELKIMSHLG--------QHENIVNLLGACTHG---------GPVLVITEYCCY--GDLLNFLRRKAEAMLGPSLSPGQDPEPGVDYKNIHLE{44}LELRDLLHFSSQVAQGMAFLASK---------------NCIHRDVAARNVLLTNGH---------VAKIGDFGLARDIMND----------SNYIVKG--NAR--LPVKWMAPESI------FDCVYTV-QSDVWSYGI-LLWEIFSLGLNPYPGI------LVNSKFYKLVKDGYQMAQPAF----------------------------------------APKNIYS-IMQACWALEPTHRPTFQQI---------CSFL
c-kit      LSFGKTLGAGAFGKVVEATAYGLIKSD---------AAMTVAVKMLKPSAHLT------------EREALMSELKVLSYLG--------NHMNIVNLLGACTIG---------GPTLVITEYCCY--GDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKES{51}LDLEDLLSFSYQVAKGMAFLASK---------------NCIHRDLAARNILLTHGR---------ITKICDFGLARDIKND----------SNYVVKG--NAR--LPVKWMAPESI------FNCVYTF-ESDVWSYGI-FLWELFSLGSSPYPGM------PVDSKFYKMIKEGFRMLSPEH----------------------------------------APAEMYD-IMKTCWDADPLKRPTFKQI---------VQLI
Flk2       LEFGKVLGSGAFGRVMNATAYGISKTG---------VSIQVAVKMLKEKADSC------------EKEALMSELKMMTHLG--------HHDNIVNLLGACTLS---------GPVYLIFEYCCY--GDLLNYLRSKREKFHRTWTEIFKEHNFSSYPTFQAHS{51}LTFEDLLCFAYQVAKGMEFLEFK---------------SCVHRDLAARNVLVTHGK---------VVKICDFGLARDILSD----------SSYVVRG--NAR--LPVKWMAPESL------FEGIYTI-KSDVWSYGI-LLWEIFSLGVNPYPGI------PVDANFYKLIQSGFKMEQPFY----------------------------------------ATEGIYF-VMQSCWAFDSRKRPSFPNL---------TSFL

Flt1       LKLGKSLGRGAFGKVVQASAFGIKKSP---------TCRTVAVKMLKEGATAS------------EYKALMTELKILTHIG--------HHLNVVNLLGACTKQG--------GPLMVIVEYCKY--GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQ{42}ITMEDLISYSFQVARGMEFLSSR---------------KCIHRDLAARNILLSENN---------VVKICDFGLARDIYKN----------PDYVRKG--DTR--LPLKWMAPESI------FDKIYST-KSDVWSYGV-LLWEIFSLGGSPYPGV------QMDEDFCSRLREGMRMRAPEY----------------------------------------STPEIYQ-IMLDCWHRDPKERPRFAEL---------VEKL
Flt4       LHLGRVLGYGAFGKVVEASAFGIHKGS---------SCDTVAVKMLKEGATAS------------EQRALMSELKILIHIG--------NHLNVVNLLGACTKPQ--------GPLMVIVEFCKY--GNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARL{39}LTMEDLVCYSFQVARGMEFLASR---------------KCIHRDLAARNILLSESD---------VVKICDFGLARDIYKD----------PDYVRKG--SAR--LPLKWMAPESI------FDKVYTT-QSDVWSFGV-LLWEIFSLGASPYPGV------QINEEFCQRVRDGTRMRAPEL----------------------------------------ATPAIRH-IMLNCWSGDPKARPAFSDL---------VEIL
Flk1       LKLGKPLGRGAFGQVIEADAFGIDKTA---------TCKTVAVKMLKEGATHS------------EHRALMSELKILIHIG--------HHLNVVNLLGACTKPG--------GPLMVIVEFSKF--GNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVD{41}LTLEHLICYSFQVAKGMEFLASR---------------KCIHRDLAARNILLSEKN---------VVKICDFGLARDIYKD----------PDYVRKG--DAR--LPLKWMAPETI------FDRVYTI-QSDVWSFGV-LLWEIFSLGASPYPGV------KIDEEFCRRLKEGTRMRAPDY----------------------------------------TTPEMYQ-TMLDCWHEDPNQRPSFSEL---------VEHL

PTK Group XV

Fibroblast growth factor receptor family


Flg        LVLGKPLGEGCFGQVVLAEAIGLDKDKPN-------RVTKVAVKMLKSDATEK------------DLSDLISEMEMMKMIG--------KHKNIINLLGACTQD---------GPLYVIVEYASK--GNLREYLQARRPPGLEYCYNPSHNPEEQ-------------LSSKDLVSCAYQVARGMEYLASK---------------KCIHRDLAARNVLVTEDN---------VMKIADFGLARDIHHI----------DYYKKTT--NGR--LPVKWMAPEAL------FDRIYTH-QSDVWSFGV-LLWEIFTLGGSPYPG-------VPVEELFKLLKEGHRMDKPSN----------------------------------------CTNELYM-MMRDCWHAVPSQRPTFKQL---------VEDL
Bek        LTLGKPLGEGCFGQVVMAEAVGIDKDKPK-------EAVTVAVKMLKDDATEK------------DLSDLVSEMEMMKMIG--------KHKNIINLLGACTQD---------GPLYVIVEYASK--GNLREYLRARRPPGMEYSYDINRVPEEQ-------------MTFKDLVSCTYQLARGMEYLASQ---------------KCIHRDLAARNVLVTENN---------VMKIADFGLARDINNI----------DYYKKTT--NGR--LPVKWMAPEAL------FDRVYTH-QSDVWSFGV-LMWEIFTLGGSPYPG-------IPVEELFKLLKEGHRMDKPAN----------------------------------------CTNELYM-MMRDCWHAVPSQRPTFKQL---------VEDL
FGFR-3     LTLGKPLGEGCFGQVVMAEAIGIDKDAA--------KPVTVAVKMLKDDATDK------------DLSDLVSEMEMMKMIG--------KHKNIINLLGACTQG---------GPLYVLVEYAAK--GNLREFLRARRPPGLDYSFDTCKPPEEQ-------------LTFKDLVSCAYQVARGMEYLASQ---------------KCIHRDLAARNVLVTEDN---------VMKIADFGLARDVHNL----------DYYKKTT--NGR--LPVKWMAPEAL------FDRVYTH-QSDVWSFGV-LLWEIFTLGGSPYPG-------IPVEELFKLLKEGHRMDKPAN----------------------------------------CTHDLYM-IMRECWHAAPSQRPTFKQL---------VEDL
FGFR-4     LVLGKPLGEGCFGQVVRAEAFGMDPARPD-------QASTVAVKMLKDNASDK------------DLADLVSEMEVMKLIG--------RHKNIINLLGVCTQE---------GPLYVIVECAAK--GNLREFLRARRPPGPDLSPDGPRSSEGP-------------LSFPVLVSCAYQVARGMQYLESR---------------KCIHRDLAARNVLVTEDN---------VMKIADFGLARGVHHI----------DYYKKTS--NGR--LPVKWMAPEAL------FDRVYTH-QSDVWSFGI-LLWEIFTLGGSPYPG-------IPVEELFSLLREGHRMDRPPH----------------------------------------CPPELYG-LMRECWHAAPSQRPTFKQL---------VEAL
DFGFR      LSLGSILGEGAFGRVVMAEAEGLPRSPQL-------AETIVAVKMVKEEHTDT------------DMASLVREMEVMKMIG--------KHINIINLLGCCSQG---------GPLWVIVEYAPH--GNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQH------LGEKELTKFAFQIARGMEYLASR---------------RCIHRDLAARNVLVSDGY---------VMKIADFGLARDIQDT----------EYYRKNT--NGR--LPIKWMAPESR------CRRRSTT-HSDVWSYGV-LLWEIMTYGDQPYPHI------LSAEELYSYLITGQRMEKPAK----------------------------------------CSLNIYV-VMRQCWHFQSCARPTFAEL---------VESF


PTK Group XVI

Insulin receptor family


INS.R      ITLLRELGQGSFGMVYEGNARDIIKGE---------AETRVAVKTVNESASLR------------ERIEFLNEASVMKGF---------TCHHVVRLLGVVSKG---------QPTLVVMELMAH--GDLKSYLRSLRPEAENNPGRPP-------------------PTLQEMIQMAAEIADGMAYLNAK---------------KFVHRDLAARNCMVAHDF---------TVKIGDFGMTRDIYET----------DYYRK----GGKGLLPVRWMAPESL------KDGVFTT-SSDMWSFGV-VLWEITSLAEQPYQG-------LSNEQVLKFVMDGGYLDQPDN----------------------------------------CPERVTD-LMRMCWQFNPNMRPTFLEI---------VNLL
IRR        ISIIRELGQGSFGMVYEGLARGLEAGE---------ESTPVALKTVNELASPR------------ECIEFLKEASVMKAF---------KCHHVVRLLGVVSQG---------QPTLVIMELMTR--GDLKSHLRSLRPEAENNPGLPQ-------------------PALGEMIQMAGEIADGMAYLAAN---------------KFVHRDLAARNCMVSQDF---------TVKIGDFGMTRDVYET----------DYYRK----GGKGLLPVRWMAPESL------KDGIFTT-HSDVWSFGV-VLWEIVTLAEQPYQG-------LSNEQVLKFVMDGGVLEELEG----------------------------------------CPLQLQE-LMSRCWQPNPRLRPSFTHI---------LDSI
IGF1R      ITMSRELGQGSFGMVYEGVAKGVVKDE---------PETRVAIKTVNEAASMR------------ERIEFLNEASVMKEF---------NCHHVVRLLGVVSQG---------QPTLVIMELMTR--GDLKSYLRSLRPEMENNPVLAP-------------------PSLSKMIQMAGEIADGMAYLNAN---------------KFVHRDLAARNCMVAEDF---------TVKIGDFGMTRDIYET----------DYYRK----GGKGLLPVRWMSPESL------KDGVFTT-YSDVWSFGV-VLWEIATLAEQPYQG-------LSNEQVLRFVMEGGLLDKPDN----------------------------------------CPDMLFE-LMRMCWQYNPKMRPSFLEI---------ISSI
DILR       IIQLAPLGQGSFGMVYEGILKSFPPNG---------VDRECAIKTVNENATDR------------ERTNFLSEASVMKEF---------DTYHVVRLLGVCSRG---------QPALVVMELMKK--VFLKSYLRAHRPRSGMRPDDVSLIAWMTGNVQP--------PTYGRIYQVAIEIADGMAYLAAK---------------KFVHRDLAARNCMVADDL---------TVKIGDFGMTRDIYET----------DYYRK----GTKGLLPVRWMPPESL------RDGVYSS-ASDVFSFGV-VLWEMATLAAQPYQG-------LSNEQVLRYVIDGGVMERPEN----------------------------------------CPDFLHK-LMQRCWHHRSSARPSFLDI---------IAYL

PTK Group XVII

LTK/ALK family


LTK        VTLLRALGHGAFGEVYEGLVIGLPGDS---------SPLQVAIKTLPELCSPQ------------DELDFLMEALIISKF---------RHQNIVRCVGLSLRA---------TPRLILLELMSG--GDMKSFLRHSRPHLGQPSP----------------------LVMRDLLQLAQDIAQGCHYLEEN---------------HFIHRDIAARNCLLMR-GPSR------VAKIGDFGMARDIYRA----------SYYRR----GDRALLPVKWMPPEAF------LEGIFTS-KTDSWSFGV-LLWEIFSLGYMPYPG-------RTNQEVLDFVVGGGRMDPPRG----------------------------------------CPGPVYR-IMTQCWQHEPELRPSFASI---------LERL
ALK        ITLIRGLGHGAFGEVYEGQVSGMPNDP---------SPLQVAVKTLPEVCSEQ------------DELDFLMEALIISKF---------NHQNIVRCIGVSLQS---------LPRFILLELMAG--GDLKSFLRETRPRPSQPSS----------------------LAMLDLLHVARDIACGCQYLEEN---------------HFIHRDIAARNCLLTCPGPGR------VAKIGDFGMARDIYRA----------SYYRK----GGCAMLPVKWMPPEAF------MEGIFTS-KTDTWSFGV-LLWEIFSLGYMPYPS-------KSNQEVLEFVTSGGRMDPPKN----------------------------------------CPGPVYR-IMTQCWQHQPEDRPNFAII---------LERI

PTK Group XVIII

Ros/Sevenless family


c-ros      LTLRLLLGSGAFGEVYEGTAVDILGVGS--------GEIKVAVKTLKKGSTDQ------------EKIEFLKEAHLMSKF---------NHPNILKQLGVCLLN---------EPQYIILELMEG--GDLLTYLRKARMATFYGPL----------------------LTLVDLVDLCVDISKGCVYLERM---------------HFIHRDLAARNCLVSVKDYTSPR----IVKIGDFGLARDIYKN----------DYYRK----RGEGLLPVRWMAPESL------MDGIFTT-QSDVWSFGI-LIWEILTLGHQPYPA-------HSNLDVLNYVQTGGRLEPPRN----------------------------------------CPDDLWN-LMTQCWAQEPDQRPTFHRI---------QDQL
7LESS      LKLLRFLGSGAFGEVYEGQLKTEDSE----------EPQRVAIKSLRKGAS--------------EFAELLQEAQLMSNF---------KHENIVRLVGICFDT---------ESISLIMEHMEA--GDLLSYLRAARATSTQEPQPTAG------------------LSLSELLAMCIDVANGCSYLEDM---------------HFVHRDLACRNCLVTESTGSTDRRR--TVKIGDFGLARDIYKS----------DYYRK----EGEGLLPVRWMSPESL------VDGLFTT-QSDVWAFGV-LCWEILTLGQQPYAA-------RNNFEVLAHVKEGGRLQQPPM----------------------------------------CTEKLYS-LLLLCWRTDPWERPSFRRC---------YNTL

PTK Group XIX

Trk/Ror family


Trk        IVLKWELGEGAFGKVFLAECHNLLPEQ---------DKMLVAVKALKEASES-------------ARQDFQREVELLTML---------QHQHIVRFFGVCTEG---------RPLLMVFEYMRH--GDLNRFLRSHGPDAKLLAGGEDVAPGP--------------LGLGQLLAVASQVAAGMVYLAGL---------------HFVHRDLATRNCLVGQGL---------VVKIGDFGMSRDIYST----------DYYRV----GGRTMLPIRWMPPESI------LYRKFTT-ESDVWSFGV-VLWEIFTYGKQPWYQ-------LSNTEAIDCITQGRELERPRA----------------------------------------CPPEVYA-IMRGCWQREPQQRHSIKDV---------HARL
TrkB       IVLKRELGEGAFGKVFLAECYNLCPEQ---------DKILVAVKTLKDASDN-------------ARKDFHREAELLTNL---------QHEHIVKFYGVCVEG---------DPLIMVFEYMKH--GDLNKFLRAHGPDAVLMAEGNPPTE----------------LTQSQMLHIAQQIAAGMVYLASQ---------------HFVHRDLATRNCLVGENL---------LVKIGDFGMSRDVYST----------DYYRV----GGHTMLPIRWMPPESI------MYRKFTT-ESDVWSLGV-VLWEIFTYGKQPWYQ-------LSNNEVIECITQGRVLQRPRT----------------------------------------CPQEVYE-LMLGCWQREPHTRKNIKNI---------HTLL
TrkC       IVLKRELGEGAFGKVFLAECYNLSPTK---------VKMLVAVKALKDPTLA-------------ARKDFQREAELLTNL---------QHEHIVKFYGVCGDG---------DPLIMVFEYMKH--GDLNKFLRAHGPDAMILVDGQPRQAKGE-------------LGLSQMLHIASQICSGMVYLASQ---------------HFVHRDLATRNCLVGANL---------LVKIGDFGMSRDVYST----------DYYRV----GGHTMLPIRWMPPESI------MYRKFTT-ESDVWSFGV-ILWEIFTYGKQPWFQ-------LSNTEVIECITQGRVLERPRV----------------------------------------CPKEVYD-VMLGCWQREPQQRLNIKEI---------YKIL
TorRTK     IEYVRDIGEGAFGRVFQARAPHLLPQE---------TSTMVAVKMLKEEASPD------------MQADFRREAALMAEF---------NHPNIVKLLGVCAVG---------KPMCLLFEYMAH--GDLNEYLRKRSPITARTLRPANCVGWSSGWGKGLTA-----LSCADQLNIAKQISAGMTYLSER---------------KFVHRDLATRNCLVGEKL---------VVKIADFGLSRNIYSA----------DYYKA----NENDAIPIRWMPPESI------FFNRYTT-ESDVWAYGV-VLWEIFSSGMQPYYG-------MAHEEVIYYVRDGNILSCPEN----------------------------------------CPPELYN-LMRLCWSNMPSDRPTFASI---------HRIL
Ror1       VRFMEELGECAFGKIYKGHLYLPGMD----------HAQLVAIKTLKDYNNPQ------------QWMEFQQEASLMAEL---------HHPNIVCLLGAVTQE---------QPVCMLFEYINQ--GDLHEFLIMRSPHSDVGCSSDEDGTVKSS------------LDHGDFLHIAIQIAAGMEYLSSH---------------FFVHKDLAARNILIGEQL---------HVKISDLGLSREIYSA----------DYYRV----QSKSLLPIRWMPPEAI------MYGKFSS-DSDIWSFGV-VLWEIFSFGLQPYYG-------FSNQEVIEMVRKRQLLPCSED----------------------------------------CPPRMYS-LMTECWNEIPSRRPRFKDI---------HVRL
Ror2       VRFMEELGEDRFGKVYKGHLFGPAPGE---------QTQAVAIKTLKDKAEGP------------LREEFRHEAMLRARL---------QHPNVVCLLGVVTKD---------QPLSMIFSYCSH--GDLHEFLVMRSPHSDVG-STDDDRTVKSA------------LEPPDFVHLVAQIAAGMEYLSSH---------------HVVHKDLATRNVLVYDKL---------NVKISDLGLFREVYAA----------DYYKL----LGNSLLPIRWMPPEAI------MYGKFSI-DSDIWSYGV-VLWEVFSYGLQPYCG-------YSNQDVVEMIRNRQVLPCPDD----------------------------------------CPAWVYA-LMIECWNEFPSRRPRFKDI---------HSRL
Dror       VEFLEELGEGAFGKVYKGQLLQPNK-----------TTITVAIKALKENASVK------------TQQDFKREIELISDL---------KHQNIVCILGVVLNK---------EPYCMLFEYMAN--GDLHEFLISNSPTEGKS------------------------LSQLEFLQIALQISEGMQYLSAH---------------HYVHRDLAARNCLVNEGL---------VVKISDFGLSRDIYSS----------DYYRV----QSKSLLPVRWMPSESI------LYGKFTT-ESDVWSFGV-VLWEIYSYGMQPYYG-------FSNQEVINLIRSRQLLSAPEN----------------------------------------CPTAVYS-LMIECWHEQSVKRPTFTDI---------SNRL

PTK Group XX

DDR/TKT family


DDR        LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPL{5}HPLLVAVKILRPDATKN------------ARNDFLKEVKIMSRL---------KDPNIIRLLGVCVQD---------DPLCMITDYMEN--GDLNQFLSAHQLEDKAAEGAPGDGQAAQGPT----------ISYPMLLHVAAQIASGMRYLATL---------------NFVHRDLATRNCLVGENF---------TIKIADFGMSRNLYAG----------DYYRV----QGRAVLPIRWMAWECI------LMGKFTT-ASDVWAFGV-TVWEVLMLCRAQPFGQ------LTDEQVIENAGEFFRDQGRQVYLSRPPA---------------------------------CPQGLYE-LMLRCWSRESEQRPPFSQL---------HRFL
TKT        LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFAL{5}QPVLVAVKMLRADANKN------------ARNDFLKEIKIMSRL---------KDPNIIHLLSVCITD---------DPLCMITEYMEN--GDLNQFLSRHEPPNSSSSDVRT-------------------VSYTNLKFMATQIASGMKYLSSL---------------NFVHRDLATRNCLVGKNY---------TIKIADFGMSRNLYSG----------DYYRI----QGRAVLPIRWMSWESI------LLGKFTT-ASDVWAFGV-TLWETFTFCQEQPYSQ------LSDEQVIENTGEFFRDQGRQTYLPQPAI---------------------------------CPDSVYK-LMLSCWRRDTKNRPSFQEI---------HLLL

PTK Group XXI

Hepatocyte growth factor family


MET        VHFNEVIGRGHFGCVYHGTLLDNDG-----------KKIHCAVKSLNRITDIG------------EVSQFLTEGIIMKDF---------SHPNVLSLLGICLRSE--------GSPLVVLPYMKH--GDLRNFIRNETHN----------------------------PTVKDLIGFGLQVAKAMKYLASK---------------KFVHRDLAARNCMLDEKF---------TVKVADFGLARDMYDK----------EYYSVHNKTGAK--LPVKWMALESL------QTQKFTT-KSDVWSFGV-VLWELMTRGAPPYPD-------VNTFDITVYLLQGRRLLQPEY----------------------------------------CPDPLYE-VMLKCWHPKAEMRPSFSEL---------VSRI
c-Sea      THRSRVIGRGHFGSVYHGTYMDPLL-----------GNLHCAVKSLHRITDLE------------EVEEFLREGILMKSF---------HHPQVLSLLGVCLPRH--------GLPLVVLPYMRH--GDLRHFIRAQERS----------------------------PTVKELIGFGLQVALGMEYLAQK---------------KFVHRDLAARNCMLDETL---------TVKVADFGLARDVFGK----------EYYSIRQHRHAK--LPVKWMALESL------QTQKFTT-KSDVWSFGV-LMWELLTRGASPYPE-------VDPYDMARYLLRGRRLPQPQP----------------------------------------CPDTLYG-VMLSCWAPTPEERPSFSGL---------VCEL
RON        THSDRVIGKGHFGVVYHGEYIDQAQ-----------NRIQCAIKSLSRITEMQ------------QVEAFLREGLLMRGL---------NHPNVLALIGIMLPPE--------GLPHVLLPYMCH--GDLLQFIRSPQRN----------------------------PTVKDLISFGLQVARGMEYLAEQ---------------KFVHRDLAARNCMLDESF---------TVKVADFGLARDILDR----------EYYSVQQHRHAR--LPVKWMALESL------QTYRFTT-KSDVWSFGV-LLWELLTRGAPPYRH-------IDPFDLTHFLAQGRRLPQPEY----------------------------------------CPDSLYQ-VMQQCWEADPAVRPTFRVL---------VGEV

PTK Group XXII

Nematode Kin15/16 family


Nkin15     EISEDKLGSGFFGEVCYGLLSMRTSNTETDTL----QKLSVAVKQSNDPTQEN------------QEKMIEDETKLMCAIG--------RNPNILAIIGAVTAN---------SGSARNLLIVEF--VECGDLLKFLEEKKSIFKDELVYEKNGYLLPKSIRRK{18}LCTSDLLSFSYQIAEGMEYLASI---------------PCVHRDLALRNVLLNKNK---------TIRIADFGLARKYQVD----------GYYRITKGVGTP--MPARWMAPEVM------REGKCTE-KSDVWSYGV-SLYEMFSLGELPYSN-------VSNSDVFEHVVQGNQLPMPQY----------------------------------------CHPKMYD-RMKQFWNFDATFRPSFSKC---------VEFF
Nkin16     LENKSILGSGNFGVVRKGILKMASPKNEEEKK----MRLTVAVKSAANCYDIS------------QTSMLAAELRLMCSIG--------RFPNVLALVGAVTS----------ELRKGRLLIVTEY-IDCGDIRKYLIDHRNVFQDHLIEDKTEPDSYLTPISA{24}LTTSDLLSFGLQIANGMQYLASI---------------PMVHRDLALRNVLLKKNK---------TIRIADFGMARTHENK----------SYYIPQKTKDAP--VPVRWMSPEAF------DTMKFTE-KSDVWSFGI-CLYEIFTLGQLPYPD-------VPSERIYEYMHSGRRCPQPQH----------------------------------------CHVELYD-LMKLCWHEKPELRPNFSNC---------VEYF

PTK Other membrane spanning kinases

RET        LVLGKTLGEGEFGKVVKATAFHLKGRA---------GYTTVAVKMLKENASPS------------ELRDLLSEFNVLKQV---------NHPHVIKLYGACSQD---------GPLLLIVEYAKY--GSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA-----LTMGDLISFAWQISQGMQYLAEM---------------KLVHRDLAARNILVAEGR---------KMKISDFGLSRDVYEE----------DSYVKRS--QGR--IPVKWMAIESL------FDHIYTT-QSDVWSFGV-LLWEIVTLGGNPYPG-------IPPERLFNLLKTGHRMERPDN----------------------------------------CSEEMYR-LMLQCWKQEPDKRPVFADI---------SKDL
KLG        LQTITTLGRGEFGEVFLAKAKGAEDAE---------GEALVLVKSLQ-TRDEQ------------LQLDFRREAEMFGKL---------NHVNVVRLLGLCREA---------EPHYMVLEYVDL--GDLKQFLRISKSKDESLKPQP--------------------LSTKHKVSLCTQVALGMEHLSNG---------------RFVHRDLAARNCLVSAQR---------QVKVSALSLSKDVYNS----------EYYHFR---QAW--IPLRWMPPEAV------LEDEFST-KSDVWSFGV-LMWEVFTQGEMPYAP-------LADDEVLAGLKSGKTKLPQPEG---------------------------------------CPSRLTK-LMQRCWAPSPKDRPSFSEL---------AAAL
Nyk/RYK    ITLKDVLQEGTFGRIFHGILIDEKDPN---------KEKQAFVKTVKDQASEI------------QVTMMLTESCKLRGL---------HHRNLLPITHVCIEEG--------EKPMVILPYMNW--GNLKLFLRQCKLVEANNPQA---------------------ISQQDLVHMAIQIACGMSYLARR---------------EVIHKDLAARNCVIDDTL---------QVKITDNALSRDLFPM-----------DYHCLG-DNEN--RPVRWMALESL------VNNEFSS-ASDVWAFGVNSLWELMTLGQTPYTLD------IDPFEMAAYLKDGYRIAQPIT----------------------------------------CPDELFA-VMACCWALDPEERPRFQQL---------VQCL
TORSO      VLLQDVLGEGAFGLVRRGVYK----------------KRQVAVKLLKDEPNDD------------EVYAFKCEIQMLKAVG--------KHPNIVGIVGYSTRFS--------NQMMLLIEYCSL--GSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFN{121}LKYADLLDIAQQVAVGMEFLAQN---------------KVVHRDLAARNVLISVDR---------SIKIADFGLSRDVYHE----------NVYRKSGG-SGK--LPIKWLALESL------THQVYTS-QSDVWSFGV-LLYEITTLGGMPYPS-------VSPSDLLQLLRQG-RMKRPEG----------------------------------------CTQEMFS-LMESCWSSVPSHRPTFSAL---------KHRL
Dtrk       LSELIQIGRGEFGDVFVGKLKATLVTSPSDKD{55}LEQLVLVKALNKVKDEQ------------ACQEFRRQLDLLRAI---------SHKGVVRLFGLCREK---------DPHYMVLEYTDW--GDLKQFLLATAGKVNTATAGSSSPPP---------------LTTSQVLAVAYQIARGMDAIYRA---------------RFTHRDLATRNCVISSEF---------IVKVSYPALCKDKYSR----------EYHKH-----RNTLLPIRWLAPECI------QEDEYTT-KSDIFAYGV-VVWELFNQATKLPHEE------LTNEQVVQRSQAGSLEWSVAE----------------------------------------ATPDSLREILLSCWVSNPKERPSFSQL---------GAAL

OPK - Other protein kinases (not falling in major groups)


OPK Group I

Polo family


Plk        YVRGRFLGKGGFAKCFEISDVD--------------TKEVFAGKIVPKSLLLKPH----------QREKMSMEISIHRSL---------AHQHVVGFHGFFEDN---------DFVFVVLELCRR--RSLLELHKRRKA-----------------------------LTEPEARYYLRQIVLGCQYLHRN---------------RVIHRDLKLGNLFLNEDL---------EVKIGDFGLATKVEYDGE----------------RKKTLCGTPNYIAPEVL------SKKGHSF-EVDVWSIGC-IMYTLLV-GKPPFET-------SCLKETYLRIKKNEY--SIPKH---------------------------------------INPVAAS-LIQKMLQTDPTARPTINELLG-------DEFF
SNK        YCRGKVLGKGGFAKCYEMTDLT--------------NNKVYAAKIIPHSRVAKPH----------QREKIDKEIELHRLL---------HHKHVVQFYHYFEDK---------ENIYILLEYCSR--RSMAHILKARKV-----------------------------LTEPEVRYYLRQIVSGLKYLHEQ---------------EILHRDLKLGNFFINEAM---------ELKVGDFGLAARLEPLEH----------------RRRTICGTPNYLSPEVL------NKQGHGC-ESDIWALGC-VMYTMLL-GRPPFET-------TNLKETYRCIREARY--TMPSS---------------------------------------LLAPAKH-LIASMLSKNPEDRPSLDDIIR-------HDFF
polo       YKRMRFFGKGGFAKCYEIIDVE--------------TDTVFAGKIVSKKLMIKHN----------QKEKTAQEITIHRSL---------NHPNIVKFHNYFEDS---------QNIYIVLELCKK--RSMMELHKRRKS-----------------------------ITEFECRYYIYQIIQGVKYLHDN---------------RIIHRDLKLGNLFLNDLL---------HVKIGDFGLATRIEYEGE----------------RKKTLCGTANYIAPEIL------TKKGHSF-EVDIWSIGC-VMYTLLV-GQPPFET-------KTLKDTYSKIKKCEY--RVPSY---------------------------------------LRKPAAD-MVIAMLQPNPESRPAIGQLLN-------FEFL
CDC5       YHRGHFLGEGGFARCFQIKDD---------------SGEIFAAKTVAKASIKSEK----------TRKKLLSEIQIHKSM---------SHPNIVQFIDCFEDD---------SNVYILLEICPN--GSLMELLKRRKV-----------------------------LTEPEVRFFTTQICGAIKYMHSR---------------RVIHRDLKLGNIFFDSNY---------NLKIGDFGLAAVLANESE----------------RKYTICGTPNYIAPEVLMG----KHSGHSF-EVDIWSLGV-MLYALLI-GKPPFQA-------RDVNTIYERIKCRDF--SFPRDKP-------------------------------------ISDEGKI-LIRDILSLDPIERPSLTEIMD-------YVWF

OPK Group II

MEK/STE7 family


MEK1       FEKISELGAGNGGVVFKVSHKP--------------SGLVMARKLIHLEIKPA------------IRNQIIRELQVLHEC---------NSPYIVGFYGAFYSD---------GEISICMEHMDG--GSLDQVLKKAGR-----------------------------IPEQILGKVSIAVIKGLTYLREKH--------------KIMHRDVKPSNILVNSRG---------EIKLCDFGVSGQLIDS------------------MANSFVGTRSYMSPERL------QGTHYSV-QSDIWSMGL-SLVEMAV-GRYPIPPPDA{36}RPPMAIFELLDYIVNEPPPKLPSGV------------------------------------FSLEFQD-FVNKCLIKNPAERADLKQLMV-------HAFI
MEK2       FERISELGAGNGGVVTKVQHRP--------------SGLIMARKLIHLEIKPA------------IRNQIIRELQVLHEC---------NSPYIVGFYGAFYSD---------GEISICMEHMDG--GSLDQVLKEAKR-----------------------------IPEQILGKVSIAVLRGLAYLREKH--------------QIMHRDVKPSNILVNSRG---------EIKLCDFGVSGQLIDS------------------MANSFVGTRSYMAPERL------QGTHYSV-QSDIWSMGL-SLVELAV-GRYPIPPPDA----RPAMAIFELLDYIVNEPPPKLPNGV------------------------------------FTPDFQE-FVNKCLIKNPAERADLKMLTN-------HTFI
Dsor1      LEKLGELGSGNGGVVMKVRHTH--------------THLIMARKLIHLEVKPA------------IKKQILRELKVLHEC---------NFPHIVGFYGAFYSD---------GEISICMEYMDG--GSLDLILKRAGR-----------------------------IPESILGRITLAVLKGLSYLRDNH--------------AIIHRDVKPSNILVNSSG---------EIKICDFGVSGQLIDS------------------MANSFVGTRSYMSPERL------QGTHYSV-QSDIWSLGL-SLVEMAI-GMYPIPPPNT{20}PRAMAIFELLDYIVNEPPPKLEHKI------------------------------------FSTEFKD-FVDICLKKQPDERADLKTLLS-------HPWI
PBS2       LEFLDELGHGNYGNVSKVLHKP--------------TNVIMATKEVRLELDEA------------KFRQILMELEVLHKC---------NSPYIVDFYGAFFIE---------GAVYMCMEYMDG--GSLDKIYDESSEIGG--------------------------IDEPQLAFIANAVIHGLKELKEQH--------------NIIHRDVKPTNILCSANQG--------TVKLCDFGVSGNLVAS------------------LAKTNIGCQSYMAPERIKSLNP-DRATYTV-QSDIWSLGL-SILEMAL-GRYPYPP-------ETYDNIFSQLSAIVQEPPPRLPSDK------------------------------------FSSDAQD-FVSLCLQKIPERRPTYAALTE-------HPWL
wis1+      IIKLEELGKGNYGVVYKALHQP--------------TGVTMALKEIRLSLEEA------------TFNQIIMELDILHKA---------VSPYIVDFYGAFFVE---------GSVFICMEYMDA--GSMDKLYAGGI------------------------------KDEGVLARTAYAVVQGLKTLKEEH--------------NIIHRDVKPTNVLVNSNG---------QVKLCDFGVSGNLVAS------------------ISKTNIGCQSYMAPERIRVGGPTNGVLTYT-QADVWSLGL-TILEMAL-GAYPYPP-------ESYTSIFAQLSAICDGDPPSLPDS-------------------------------------FSPEARD-FVNKCLNKNPSLRPDYHELAN-------HPEL
MKK1       IETLGILGEGAGGSVSKCKLKN--------------GSKIFALKVINTLNTDPE-----------YQKQIFRELQFNRSF---------QSEYIVRYYGMFTDDEN-------SSIYIAMEYMGG--RSLDAIYKNLLERGGR-------------------------ISEKVLGKIAEAVLRGLSYLHEK---------------KVIHRDIKPQNILLNENG---------QVKLCDFGVSGEAVNS------------------LATTFTGTSFYMAPERI------QGQPYSV-TSDVWSLGL-TILEVAN-GKFPCSSEKM----AANIAPFELLMWILTFTPELKDEPESNII--------------------------------WSPSFKS-FIDYCLKKDSRERPSPRQMIN-------HPWI
MKK2       ITTLGILGEGAGGSVAKCRLKN--------------GKKVFALKTINTMNTDSE-----------YQKQIFRELQFNKSF---------KSDYIVQYYGMFTDEQS-------SSIYIAMEYMGG--KSLEATYKNLLKRGGR-------------------------ISERVIGKIAESVLRGLSYLHER---------------KVIHRDIKPQNILLNEKG---------EIKLCDFGVSGEAVNS------------------LAMTFTGTSFYMAPERI------QGQPYSV-TCDVWSLGL-TLLEVAG-GRFPFESDKI----TQNVAPIELLTMILTFSPQLKDEPELDIS--------------------------------WSKTFRS-FIDYCLKKDARERPSPRQMLK-------HPWI
byr1+      LEVVRHLGEGNGGAVSLVKHRN----------------IFMARKTVYVGSDSK------------LQKQILRELGVLHHC---------RSPYIVGFYGAFQYK---------NNISLCMEYMDC--GSLDAILREGGP-----------------------------IPLDILGKIINSMVKGLIYLYNVL--------------HIIHRDLKPSNVVVNSRG---------EIKLCDFGVSGELVNS------------------VAQTFVGTSTYMSPERI------RGGKYTV-KSDIWSLGI-SIIELAT-QELPWSFSNI----DDSIGILDLLHCIVNEEPPRLPSS-------------------------------------FPEDLRL-FVDACLHKDPTLRASPQQLCA-------MPYF
STE7       LVQLGKIGAGNSGTVVKALHVP--------------DSKIVAKKTIPVEQNNST-----------IINQLVRELSIVKNVK--------PHENIITFYGAYYNQHIN------NEIIILMEYSDC--GSLDKILSVYKRFVQRGTVSSKKTW----------------FNELTISKIAYGVLNGLDHLYRQY--------------KIIHRDIKPSNVLINSKG---------QIKLCDFGVSKKLINS------------------IADTFVGTSTYMSPERI------QGNVYSI-KGDVWSLGL-MIIELVT-GEFPLGGHN-----DTPDGILDLLQRIPSPRLPKDRI--------------------------------------YSKEMTD-FVNRCCIKNERERSSIHELLH-------HDLI

OPK Group III

PAK/STE20 family


PAK        YTRFEKIGQGASGTVYTAMDVA--------------TGQEVAIKQMNLQQQP-------------KKELIINEILVMREN---------KNPNIVNYLDSYLVG---------DELWVVMEYLAG--GSLTDVVTETC------------------------------MDEGQIAAVCRECLQALEFLHSN---------------QVIHRDIKSDNILLGMDG---------SVKLTDFGFCAQITPEQS----------------KRSTMVGTPYWMAPEVV------TRKAYGP-KVDIWSLGI-MAIEMIE-GEPPYLNENPL---RALYLIATNGTPELQNPEK------------------------------------------LSAIFRD-FLNRCLEMDVEKRGSAKELLQ-------HQFL
STE20      YANLVKIGQGASGGVYTAYEIG--------------TNVSVAIKQMNLEKQP-------------KKELIINEILVMKGS---------KHPNIVNFIDSYVLK---------GDLWVIMEYMEG--GSLTDVVTHCI------------------------------LTEGQIGAVCRETLSGLEFLHSK---------------GVLHRDIKSDNILLSMEG---------DIKLTDFGFCAQINELNL----------------KRTTMVGTPYWMAPEVV------SRKEYGP-KVDIWSLGI-MIIEMIE-GEPPYLNETPL---RALYLIATNGTPKLKEPEN------------------------------------------LSSSLKK-FLDWCLCVEPEDRASATELLH-------DEYI

OPK Group IV

MEKK/STE11 family


MEKK       WLKGQQIGLGAFSSCYQAQDVG--------------TGTLMAVKQVTYVRNTSSEQEE-------VVEALREEIRMMGHL--------NHPNIIRMLGATCEK----------SNYNLFIEWMAG--GSVAHLL--SKYGA---------------------------FKESVVINYTEQLLRGLSYLHEN---------------QIIHRDVKGANLLIDSTGQ--------RLRIADFGAAARLASKGTGAGE------------FQGQLLGTIAFMAPEVL------RGQQYGR-SCDVWSVGC-AIIEMAC-AKPPWNAEKHS---NHLALIFKIASATTAPSIPSH----------------------------------------LSPGLRD-VAVRCLELQPQDRPPSRELLK-------HPVF
STE11      WLKGACIGSGSFGSVYLGMNAH--------------TGELMAVKQVEIKNNNIGVPTDNNK{35}MVDALQHEMNLLKEL---------HHENIVTYYGASQEG---------GNLNIFLEYVPG--GSVSSML--NNYGP---------------------------FEESLITNFTRQILIGVAYLHKK---------------NIIHRDIKGANILIDIKG---------CVKITDFGISKKLSPLNKKQN-------------KRASLQGSVFWMSPEVV------KQTATTA-KADIWSTGC-VVIEMFT-GKHPFPDF------SQMQAIFKIGTNTTPEIPSW-----------------------------------------ATSEGKN-FLRKAFELDYQYRPSALELLQ-------HPWL
byr2       WIRGALIGSGSFGQVYLGMNAS--------------SGELMAVKQVILDSVSEKDRHAK------LLDALAGEIALLQEL---------SHEHIVQYLGSNLNS---------DHLNIFLEYVPG--GSVAGLL--TMYGS---------------------------FEETLVKNFIKQTLKGLEYLHSR---------------GIVHRDIKGANILVDNKG---------KIKISDFGISKKLELNSTSTKTGG----------ARPSFQGSSFWMAPEVV------KQTMHTE-KTDIWSLGC-LVIEMLT-SKHPYPNC------DQMQAIFRIGENILPEFPSN-----------------------------------------ISSSAID-FLEKTFAIDCNLRPTASELLS-------HPFV
BCK1       WMKGEMIGKGSFGAVYLCLNVT--------------TGEMMAVKQVEVPKYSSQNEAILS-----TVEALRSEVSTLKDL---------DHLNIVQYLGFENKN---------NIYSLFLEYVAG--GSVGSLI--RMYGR---------------------------FDEPLIKHLTTQVLKGLAYLHSK---------------GILHRDMKADNLLLDQDG---------ICKISDFGISRKSKDIYSN---------------SDMTMRGTVFWMAPEMVD-----TKQGYSA-KVDIWSLGC-IVLEMFA-GKRPWSNL------EVVAAMFKIGKSKSAPPIPEDTLPL------------------------------------ISQIGRN-FLDACFEINPEKRPTANELLS-------HPFS
NPK1       WRKGEMIGCGAFGRVYMGMNVD--------------SGELLAIKEVSIAMNGASRERAQA-----HVRELEEEVNLLKNL---------SHPNIVRYLGTAREA---------GSLNILLEFVPG--GSISSLL--GKFGS---------------------------FPESVIRMYTKQLLLGLEYLHKN---------------GIMHRDIKGANILVDNKG---------CIKLADFGASKKVVELATMT--------------GAKSMKGTPYWMAPEVI------LQTGHSF-SADIWSVGC-TIIEMAT-GKPPWSQQY-----QEVAALFHIGTTKSHPPIPEH----------------------------------------LSAESKD-FLLKCLQKEPHLRHSASNLLQ-------HPFV

OPK Group V

NimA family


Nek1       YVRLQKIGEGSFGKAVLVKSTE--------------DGRHYVIKEINISRMSDK-----------ERQESRREVAVLANM---------KHPNIVQYKESFEEN---------GSLYIVMDYCEG--GDLFKRINAQKGAL---------------------------FQEDQILDWFVQICLALKHVHDR---------------KILHRDIKSQNIFLTKDG---------TVQLGDFGIARVLNSTVE----------------LARTCIGTPYYLSPEIC------ENKPYNN-KSDIWALGC-VLYELCT-LKHAFEA-------GNMKNLVLKIISGSFPPVSPH----------------------------------------YSYDLRS-LLSQLFKRNPRDRPSVNSILE-------KGFI
NrkA       YLNKGIVGLGSYGEAYVAESVE--------------DGSLCVAKVMDLSKMSQR-----------DKRYAQSEIKCLANC---------NHPNIIRYIEDHEEN---------DRLLIVMEFADS--GNLDEQIKLRGSGDARY------------------------FQEHEALFLFLQLCLALDYIHSH---------------KMLHRDIKSANVLLTSTG---------LVKLGDFGFSHQYEDTVSGV--------------VASTFCGTPYYLAPELW------NNKRYNK-KADVWSLGV-LLYEIMG-MKKPFSA-------SNLKGLMSKVLAGTYAPLPDS----------------------------------------FSSEFKR-VVDGILVADPNDRPSVREIFQ-------IPYI
nimA       YEVLEKIGCGSFGIIRKVKRKS--------------DGFILCRKEINYIKMSTK-----------EREQLTAEFNILSSL---------RHPNIVAYYHREHLKAS-------QDLYLYMEYCGG--GDLSMVIKNLKRTNKY-------------------------AEEDFVWRILSQLVTALYRCHYGTDPAEVGSNLL{16}TILHRDLKPENIFLGSDN---------TVKLGDFGLSKLMHSHD-----------------FASTYVGTPFYMSPEIC------AAEKYTL-RSDIWAVGC-IMYELCQ-REPPFNA-------RTHIQLVQKIREGKFAPLPDF----------------------------------------YSSELKN-VIASCLRVNPDHRPDTATLIN-------TPVI
KIN3       YQVLEEIGRGSFGSVRKVIHIP--------------TKKLLVRKDIKYGHMNSK-----------ERQQLIAECSILSQL---------KHENIVEFYNWDFDEQK-------ELLYLYMEYCSR--GDLSQMIKHYKQQHKY-------------------------IPEKIIWGILAQLLTALYKCHYGVELPTLTTIYD{10}IVIHRDLKPGNIFLSYDDSDYNI{34}VVKLGDFGLSQISETSIQ----------------FATTYVGTPYYMSPEVL------MDQPYSP-LSDIWSLGC-VIFEMCS-LHPPFQA-------KNYLELQTKIKNGKCDTVPEY----------------------------------------YSRGLNA-IIHSMIDVNLRTRPSTFELLQ-------DIQI
FUSED      YAVSSLVGQGSFGCVYKATRKD--------------DSKVVAIKVISKRGRATK-----------ELKNLRRECDIQARL---------KHPHVIEMIESFESK---------TDLFVVTEFALM---DLHRYLSYNGA-----------------------------MGEEPARRVTGHLVSALYYLHSN---------------RILHRDLKPQNVLLDKNM---------HAKLCDFGLARNMTLGTH----------------VLTSIKGTPLYMAPELL------ADEPYDH-HADMWSLGC-IAYESMA-GQPPFCA-------SSILHLVKMIKHEDVKW-PST----------------------------------------LTCECRS-FLQGLLEKDPGLRISWTQLLC-------HPFV

OPK Group VI

wee1/mik1 family


wee1+      FRNVTLLGSGEFSEVFQVEDPVE-------------KTLKYAVKKLKV---KFSGPK--------ERNRLLQEVSI-QRALK-------GHDHIVELMDSWEHG---------GFLYMQVELCEN--GSLDRFLEEQGQLSR--------------------------LDEFRVWKILVEVALGLQFIHHK---------------NYVHLDLKPANVMITFEG---------TLKIGDFGMASVWPVP------------------RGMEREGDCEYIAPEVL------ANHLYDK-PADIFSLGI-TVFEAAA--NIVLPDN------GQSWQKLRSGDLSPRLSSTD-------------------NGSSLTSSSRETPANSII----GQGGLDR-VVEWMLSPEPRNRPTIDQILATD-----EVCW
mik1+      FQQVKPIHESDFSFVYHVSSINPP------------TETVYVVKMLKKNAAKFTG-K--------ERHL--QEVSILQRLQ--------ACPFVVNLVNVWSYN---------DNIFLQLDYCEN--GDLSLFLSELGLLQV--------------------------MDPFRVWKMLFQLTQALNFIHLL---------------EFVHLDVKPSNVLITRDG---------NLKLGDFGLATSLPVS------------------SMVDLEGDRVYIAPEIL------ASHNYGK-PADVYSLGL-SMIEAAT--NVVLPEN------GVEWQRLRSGDYSNLP-----------------------NLKDLLLSKEKVQINKVR----CAESLQC-LLQRMTHPYVDCRPTTQDLLAMP-----EMIF
HsWee1     FHELEKIGSGEFGSVFKCVKRL--------------DGCIYAIKRSKKPLAGSV-----------DEQNALREVYAHAVLG--------QHSHVVRYFSAWAED---------DHMLIQNEYCNG--GSLADAI-SENYRIMSY------------------------FKEAELKDLLLQVGRGLRYIHSM---------------SLVHMDIKPSNIFISRTSIPNAA{14}MFKIGDLGHVTRIS--------------------SPQVEEGDSRFLANEVLQ-----ENYTHLP-KADIFALAL-TVVCAAG--AEPLPRN------GDQWHEIRQGRLPRIPQV-------------------------------------------LSQEFTE-LLKVMIHPDPERRPSAMALVK-------HSVL

OPK Group VII

Kinases involved in transcriptional control family


HRI        FEELSILGKGGYGRVYKVRNKL--------------DGQYYAIKKILIKGATKT-----------DCMKVLREVKVLAGL---------QHPNIVGYHTAWIEHVHVH{128}LMLHIQMQLCEL---SLWDWIAERNRRSRECVDESACPY----------------VMVSVATKIFQELVEGVFYIHNM---------------GIVHRDLKPRNIFLHGPDDQ-------QVKIGDFGLACADIIQKNAARTSRNGERAP----THTSRVGTCLYASPEQL------EGSEYDA-KSDMYSVGV-ILLELFQ----PFGTE------MERAEVLTGVRAGRIPDSLSK----------------------------------------RCPAQAK-YVQLLTRRNASQRPSALQLLQ-------SELF
PKR        FKEIELIGSGGFGQVFKAKHRI--------------DGKTYVIKRVKY-----------------NNEKAEREVKALAKL---------DHVNIVHYNGCWDGFDYDPE{24}KCLFIQMEFCDK--GTLEQWIEKRRGEK---------------------------LDKVLALELFEQITKGVDYIHSK---------------KLIHRDLKPSNIFLVDTK---------QVKIGDFGLVTSLKNDG-----------------KRTRSKGTLRYMSPEQI------SSQDYGK-EVDLYALGL-ILAELLH----VCDTA------FETSKFFTDLRDGIISDI-------------------------------------------FDKKEKT-LLQKLLSKKPEDRPNTSEILR-------TLTV
GCN2       LKRLNFSGQGAFGQVVKARNAL--------------DSRYYAIKKIRNTEE--------------KLSTMISEVMLLASL---------NHQYVVRYYAAWLEEDSMD{112}STLFIQMEYCEN--RTLYDLIHSENLN----------------------------QQRDEYWRLFRQILEALSYIHSQ---------------GIIHRDLKPKNIFIDESR---------NVKIGDFGLAKNVHRSLDILKDSQNLPGSSDN--LLTSAIGTAMYVATEVLD-----GTGHYNE-KIDMYSLGI-IFFEMIY----PFSTG------MERVNILKKLRSVSIEFPPDFDDN-------------------------------------KNKVEKK-IIRLLIDHDPNKRPGARTLLN-------SGWL

OPK Group VIII

Raf family


c-raf      VMLSTRIGSGSFGTVYKGKWHG-----------------DVAVKILKVVDPTPE-----------QFQAFRNEVAVLRKT---------RHVNILLFMGYMTK----------DNLAIVTQWCEG--SSLYKHLHVQETK----------------------------FQMFQLIDIARQTAQGMDYLHAK---------------NIIHRDMKSNNIFLHEGL---------TVKIGDFGLATVKSRWSGSQ--------------QVEQPTGSVLWMAPEVIR--MQ-DNNPFSF-QSDVYSYGI-VLYELMT-GELPYSHI------NNRDQIIFMVGRGYASPDLSKLYKN------------------------------------CPKAMKR-LVADCVKKVKEERPLFPQILSSIELLQ-HSLP
Araf       VQLLKRIGTGSFGTVFRGRWHG-----------------DVAVKVLKVSQPTAE-----------QAQAFKNEMQVLRKT---------RHVNILLFMGFMTR----------PGFAIITQWCEG--SSLYHHLHVADTR----------------------------FDMVQLIDVARQTAQGMDYLHAK---------------NIIHRDLKSNNIFLHEGL---------TVKIGDFGLATVKTRWSGAQ--------------PLEQPSGSVLWMAAEVIR--MQ-DPNPYSF-QSDVYAYGV-VLYELMT-GSLPYSHI------GCRDQIIFMVGRGYLSPDLSKISSN------------------------------------CPKAMRR-LLSDCLKFQREERPLFPQILATIELLQ-RSLP
Braf       ITVGQRIGSGSFGTVYKGKWHG-----------------DVAVKMLNVTAPTPQ-----------QLQAFKNEVGVLRKT---------RHVNILLFMGYSTK----------PQLAIVTQWCEG--SSLYHHLHIIETK----------------------------FEMIKLIDIARQTAQLMDYLHAK---------------SIIHRDLKSNNIFLHEDL---------TVKIGDFGLATVKSRWSGSH--------------QFEQLSGSILWMAPEVIR--MQ-DKNPYSF-QSDVYAFGI-VLYELMT-GQLPYSNI------NNRDQIIFMVGRGYLSPDLSKVRSN------------------------------------CPKAMKR-LMAECLKKKRDERPLFPQILASIELLA-RSLP
DmRaf      ILIGPRIGSGSFGTVYRAHWHG-----------------PVAVKTLNVKTPSPA-----------QLQAFKNEVAMLKKT---------RHCNILLFMGCVSK----------PSLAIVTQWCEG--SSLYKHVHVSETK----------------------------FKLNTLIDIGRQVAQGMDYLHAK---------------NIIHRDLKSNNIFLHEDL---------SVKIGDFGLATAKTRWSGEK--------------QANQPTGSILWMAPEVIR--MQ-ELNPYSF-QSDVYAFGI-VMYELLA-ECLPYGHI------SNKDQILFMVGRGLLRPDMSQVRSD------------------------------------ARRHSKR-LAEDCIKYTPKDRPLFRPLLNMLENML-RTLP
CeRaf      FIIQYKVGSGSFGTVYRGEFFG-----------------TVAIKKLNVVDPTPS-----------QMAAFKNEVAVLKKT---------RHLNVLLFMGWVRE----------PEIAIITQWCEG--SSLYRHIHVQEPRVE--------------------------FEMGAIIDILKQVSLGMNYLHSK---------------NIIHRDLKTNNIFLMDDMS--------TVKIGDFGLATVKTKWTVNGGQ------------QQQQPTGSILWMAPEVIR--MQ-DDNPYTP-QSDVYSFGI-CMYEILS-SHLPYSNI------NNRDQILFMVGRGYLRPDRSKIRHD------------------------------------TPKSMLK-LYDNCIMFDRNERPVFGEVLERLRDII-LPKL
Ctr1       LNIKEKIGAGSFGTVHRAEWHG----------------SDVAVKILMEQDFHAE-----------RVNEFLREVAIMKRL---------RHPNIVLFMGAVTQP---------PNLSIVTEYLSR--GSLYRLLHKSGAREQ--------------------------LDERRRLSMAYDVAKGMNYLHNRNP-------------PIVHRDLKSPNLLVDKKY---------TVKVCDFGLSRLKASTFL----------------SSKSAAGTPEWMAPEVLR-----D-EPSNE-KSDVYSFGV-ILWELAT-LQQPWGNL-------NPAQVVAAVGFKCKRLEIPRN---------------------------------------LNPQVAA-IIEGCWTNEPWKRPSFATIMDLLRPIK-SAVP

OPK Group IX

Activin/TGFb receptor family


TGFbRII    IELDTLVGKGRFAEVYKAKLKQNTSEQF----------ETVAVKIFPYDHY--------------ASWKDRKDIFSDINL---------KHENILQFLTAEERKTELG-----KQYWLITAFHAK--GNLQEYLTRHV------------------------------ISWEDLRNVGSSLARGLSHLHSDHTPCGRP------KMPIVHRDLKSSNILVKNDL---------TCCLCDFGLSLRLGPYSSVDDLAN------------SGQVGTARYMAPEVLESRMN-LENAESFKQTDVYSMAL-VLWEMT{13}PPFGS-------KVRDPVVESMKDNVLRDRGTRNSS-FWLNHQ------------------------------GIQMVCE-TLTECWDHDPEARLTAQCVAERFSE---LEHL
ActRIIA    LQLLEVKARGRFGQVWKAQLLN----------------EYVAVKIFPIQDK--------------QSWQNEYEVYSLPGM---------KHENILQFIGAEKRGTSVD-----VDLWLITAFHEK--GSLSDFLKANV------------------------------VSWNELCHIAETMARGLAYLHEDIPGLK-DGH----KPAISHRDIKSKNVLLKNNL---------TACIADFGLALKFAEGKSAGDT--------------HGQVGTRRYMAPEVLEGAIN-FQR-DAFLRIDMYAMGL-VLWELA{14}LPFEEE------IGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA------------------------------GMAMLCE-TIEECWDHDAEARLSAGCVGERITQ---MQRL
ActRIIB    LQLLEIKARGRFGQVWKAQLMN----------------DFVAVKIFPLQDK--------------QSWQSEREIFSTPGM---------KHENLLQFIAAEKRGSNLE-----VELWLITAFHDK--GSLTDYLKGNI------------------------------ITWNELCHVAETMSRGLSYLHEDVPWCRGEGH----KPSIAHRDFKSKNVLLKSDL---------TAVLADFGLAVRFEPGKPPGDT--------------HGQVGTRRYMAPEVLEGAIN-FQR-DAFLRIDMYAMGL-VLWELV{14}LPFEEE------IGQHPSLEELQEVVVHKKMRPTIKDHWLKHP------------------------------GLAQLCV-TIEECWDHDAEARLSAGCVEERVSL---IRRS
TSR-1      VALVECVGKGRYGEVWRGLWHG----------------ESVAVKIFSSRDE--------------QSWFRETEIYNTVLL---------RHDNILGFIASDMTSRNSS-----TQLWLITHYHEH--GSLYDFLQRQT------------------------------LEPHLALRLAVSAACGLAHLHVEIFGTQG-------KPAIAHRDFKSRNVLVKSNL---------QCCIADLGLAVMHSQGSDYLDIGN------------NPRVGTKRYMAPEVLDEQIR-TDCFESYKWTDIWAFGL-VLWEIA{13}PPFYDV------VPNDPSFEDMKKVVCVDQQTPTIPNRLAADP------------------------------VLSGLAQ-MMRECWYPNPSARLTALRIKKTLQK---ISNS
TskL7      ITLLECVGKGRYGEVWRGSWQG----------------ENVAVKIFSSRDE--------------KSWFRETELYNTVML---------RHENILGFIASDMTSRHSS-----TQLWLITHYHEM--GSLYDYLQLTT------------------------------LDTVSCLRIVLSIASGLAHLHIEIFGTQG-------KSAIAHRDLKSKNILVKKNG---------QCCIADLGLAVMHSQSTNQLDVGN------------NPRVGTKRYMAPEVLDETIQ-VDCFDSYKRVDIWAFGL-VLWEVA{13}PPFYDV------VPNDPSFEDMRKVVCVDQQRPNIPNRWFSDP------------------------------TLTSLAK-LMKECWYQNPSARLTALRIKKTLTK---IDNS
ALK-3      IQMVRQVGKGRYGEVWMGKWRG----------------EKVAVKVFFTTEE--------------ASWFRETEIYQTVLM---------RHENILGFIAADIKGTGSW-----TQLYLITDYHEN--GSLYDFLKCAT------------------------------LDTRALLKLAYSAACGLCHLHTEIYGTQG-------KPAIAHRDLKSKNILIKKNG---------SCCIADLGLAVKFNSDTNEVDVPL------------NTRVGTKRYMAPEVLDESLN-KNHFQPYIMADIYSFGL-IIWEMA{13}LPYYNM------VPSDPSYEDMREVVCVKRLRPIVSNRWNSDE------------------------------CLRAVLK-LMSECWAHNPASRLTALRIKKTLAK---MVES
ALK-4      IVLQEIIGKGRFGEVWRGRWRG----------------GDVAVKIFSSREE--------------RSWFREAEIYQTVML---------RHENILGFIAADNKDNGTW-----TQLWLVSDYHEH--GSLFDYLNRYT------------------------------VTIEGMIKLALSAASGLAHLHMEIVGTQG-------KPGIAHRDLKSKNILVKKNG---------MCAIADLGLAVRHDAVTDTIDIAP------------NQRVGTKRYMAPEVLDETIN-MKHFDSFKCADIYALGL-VYWEIA{14}LPYYDL------VPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE------------------------------ALRVMGK-MMRECWYANGAARLTALRIKKTLSQ---LSVQ
ALK-5      IVLQESIGKGRFGEVWRGKWRG----------------EEVAVKIFSSREE--------------RSWFREAEIYQTVML---------RHENILGFIAADNKDNGTW-----TQLWLVSDYHEH--GSLFDYLNRYT------------------------------VTVEGMIKLALSTASGLAHLHMEIVGTQG-------KPAIAHRDLKSKNILVKKNG---------TCCIADLGLAVRHDSATDTIDIAP------------NHRVGTKRYMAPEVLDDSIN-MKHFESFKRADIYAMGL-VFWEIA{13}LPYYDL------VPSDPSVEEMRKVVCEQKLRPNIPNRWQSCE------------------------------ALRVMAK-IMRECWYANGAARLTALRIKKTLSQ---LSQQ
ALK-6      IQMVKQIGKGRYGEVWMGKWRG----------------EKVAVKVFFTTEE--------------ASWFRETEIYQTVLM---------RHENILGFIAADIKGTGSW-----TQLYLITDYHEN--GSLYDYLKSTT------------------------------LDAKSMLKLAYSSVSGLCHLHTEIFSTQG-------KPAIAHRDLKSKNILVKKNG---------TCCIADLGLAVKFISDTNEVDIPP------------NTRVGTKRYMPPEVLDESLN-RNHFQSYIMADMYSFGL-ILWEIA{13}LPYHDL------VPSDPSYEDMREIVCMKKLRPSFPNRWSSDE------------------------------CLRQMGK-LMTECWAQNPASRLTALRVKKTLAK---MSES
C14        LRFSQVIQEGGHAVVWAGRLQG----------------EMVAIKAFPPRAV--------------AQFRAERAVYQLLGL---------QHNHIVRFITAGQGGPGPLP----SGPLLVLELYPK--GSLCHYLTQYT------------------------------SDWGSSLRMALSLAEGLAFLHGERWQDGQY------KPGIAHRDLSSQNVLIREDR---------SCAIGDLGLALVLPGLAQPPALAPTQPRGPAA----ILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLAL-LLWEIL{12}PPFQLAYEAE--LGSNPSACELWALAVAERKRPNIPSSWSCSAT-----------------------------DPRGLRE-LLEDCWDADPEARLTAECVQQRLAA---LAYP
Daf1       IRLTGRVGSGRFGNVSRGDYRG----------------EAVAVKVFNALDE--------------PAFHKETEIFETRML---------RHPNVLRYIGSDRVDTGFV-----TELWLVTEYHPS--GSLHDFLLENT------------------------------VNIETYYNLMRSTASGLAFLHNQIGGSK-ESN----KPAMAHRDIKSKNIMVKNDL---------TCAIGDLGLSLSKPEDAASDIIANEN----------NYKCGTVRYLAPEILNSTMQ-FTVFESYQCADVYSFSL-VMWETL{15}IPYIEW------TDRDPQDAQMFDVVCTRRLRPTENPLWKDHP------------------------------EMKHIME-IIKTCWNGNPSARFTSYICRKRMDE---RQQL
Daf4       ITDFQLISKGRFGKVFKAQYTPDSGEK-----------RLVAVKKLNEFQK--------------ASFLAEKRIFDELNE----------YPKWYKSIVEFVCPEKIG-----DEYWIVTEFHER--LSLYELLKNNV------------------------------ISITSANRIIMSMIDGLQFLHDDRPYFFGHPK----KP-IIHRDIKSKNILVKSDM---------TTCIADFGLARIYSYDIEQSDL--------------LGQVGTKRYMSPEMLEGATE-FTP-TAFKAMDVYSMGL-VMWEVI{15}MPFQVI------GFDPTIGRMRNYVV-SKKERPQWRDEIIKHE------------------------------YMSLLKK-VTEEMWDPEACARITAGCAFARVWN---HIMS
DmAtr-II   IQLLEQKASGRFGDVWQAKLNN----------------QDVAVKIFRMQEK--------------ESWTTEHDIYKLPRM---------RHPNILEFLGVEKHMDK-------PEYWLISTYQHN--GSLCDYLKSHT------------------------------ISWPELCRIAESMANGLAHLHEEIPASKTDGL----KPSIAHRDFKSKNVLLKSDL---------TACIADFGLAMIFQPGKPCGDT--------------HGQVGTRRYMAPEVLEGAIN-FNR-DAFLRIDVYACGL-VLWEMV{13}LPFEAE------LGLRPSLDEVQESVVMKKLRPRLLNSWRAHP------------------------------GLNVFCD-TMEECWDHDAEARLSSSCVMERFAQ---LNKY
DmSax      VTLIECIGRGKYGEVWRGHWHG----------------ESIAVKIFFSRDE--------------ESWKRETEIYSTILL---------RHENILGFIGSDMTSRNSC-----TQLWLMTHYYPL--GSLFDHLNRNA------------------------------LSHNDMVWICLSIANGLVHLHTEIFGKQG-------KPAMAHRDLKSKNILVTSNG---------SCVIADFGLAVTHSHVTGQLDLGN------------NPKVGTKRYMAPEVLDESID-LECFEALRRTDIYAFGL-VLWEVC{13}VPFYDV------VPMDPSFEDMRKVVCIDNYRPSIPNRWSSNS------------------------------LMTGMSK-LMKECWHQNPDVRLPALRIKKTIHK---LASA

OPK Group X

Flowering plant putative receptor kinases and close relatives family


SR2        FSDFNKVGKGGFGVVYKGRLV---------------DGQEIAVKRLSEMSAQ-------------GTDEFMNEVRLMQSF---------SHNNLVRLLGCCVYE---------GEKILIYEYLEN--LSLDSHLFDETRSCM--------------------------LNWQMRFDIINGIARGLLYLHQDSRF------------RIIHRDLKASNVLLDKDM---------TPKISDFGMARIFGRDETEA--------------DTRKVVGTYGYMSPEYA------MNGTFSM-KSDVFSFGV-ILLEIIS-GKRNKGLC------DSDSSLNLLGCVWRNWKEGQGLEI---------------VDKVIIDS-SS-PT-FRPR---EILRCLQ-IGLLCVQERVEDRPMMSSV---------VLML
SR6        FSSCNKLGQGGFGIVYKGRLL---------------DGKEIAVKRLSKTSVQ-------------GTDEFMNEVTLIARL---------QHINLVQVLGCCIEG---------DEKMLIYEYLEN--LSLDSYLFGKTRRSK--------------------------LNWNERFDITNGVARGLLYLHQDSRF------------RIIHRDLKVSNILLDKNM---------IPKISDFGMARIFERDETEA--------------NTMKVVGTYGYMSPEYA------MYGIFSE-KSDVFSFGV-IVLEIVS-GKKNRGFY------NLDYENDLLSYVWSRWKEGRALEI---------------VDPVIVDSLSSQPSIFQPQ---EVLKCIQ-IGLLCVQELAEHRPAMSSV---------VWMF
Pto        FDHKFLIGHGVFGKVYKGVLR---------------DGAKVALKRRTPESSQ-------------GIEEFETEIETLSFC---------RHPHLVSLIGFCDER---------NEMILIYKYMEN--GNLKRHLYGSDLPTMS-------------------------MSWEQRLEICIGAARGLHYLHTR---------------AIIHRDVKSINILLDENF---------VPKITDFGISKKGTELDQTH--------------LSTVVKGTLGYIDPEYF------IKGRLTE-KSDVYSFGV-VLFEVLC-ARSAIVQ-------SLPREMVNLAEWAVESHNNGQLEQI--------------VDPNLADKI--RPE--------SLRKFGD-TAVKCLALSSEDRPSMGDV---------LWKL
TMK1       FSSDNILGSGGFGVVYKGELH---------------DGTKIAVKRMENGVIAGK-----------GFAEFKSEIAVLTKV---------RHRHLVTLLGYCLDG---------NEKLLVYEYMPQ--GTLSRHLFEWSEEGLKP------------------------LLWKQRLTLALDVARGVEYLHGLAHQ------------SFIHRDLKPSNILLGDDM---------RAKVADFGLVRLAPEGKGS---------------IETRIAGTFGYLAPEYA------VTGRVTT-KVDVYSFGV-ILMELIT-GRKSLDE-------SQPEESIHLVSWFKRMYINKEASFKKA------------IDT-TIDLDEETLA--------SVHTVAE-LAGHCCAREPYQRPDMGHA---------VNIL
APK1       FRPDSVLGEGGFGCVFKGWIDEKSLTASRPG-----TGLVIAVKKLNQDGWQ-------------GHQEWLAEVNYLGQF---------SHRHLVKLIGYCLED---------EHRLLVYEFMPR--GSLENHLFRRGLYFQP-------------------------LSWKLRLKVALGAAKGLAFLHSSET-------------RVIYRDFKTSNILLDSEY---------NAKLSDFGLAKDGPIGDKSH--------------VSTRVMGTHGYAAPEYL------ATGHLTT-KSDVYSFGV-VLLELLS-GRRAVDK-------NRPSGERNLVEWAKPYLVNKRKIFRV-------------IDN-RLQDQYSME---------EACKVAT-LSLRCLTTEIKLRPNMSEV---------VSHL
NAK        FRPDSVVGEGGFGCVFKGWIDESSLAPSKPG-----TGIVIAVKRLNQEGFQ-------------GHREWLAEINYLGQL---------DHPNLVKLIGYCLEE---------EHRLLVYEFMTR--GSLENHLFRRGTFYQP-------------------------LSWNTRVRMALGAARGLAFLHNAQP-------------QVIYRDFKASNILLDSNY---------NAKLSDFGLARDGPMGDNSH--------------VSTRVMGTQGYAAPEYL------ATGHLSV-KSDVYSFGV-VLLELLS-GRRAIDK-------NQPVVEHNLVDWARPYLTNKRRLLRV-------------MDP-RLQGQYSLT---------RALKIAV-LALDCISIDAKSRPTMNEI---------VKTM
ZMPK1      RKFKVELGRGESGTVYKGVLE---------------DDRHVAVKKLENVRQ--------------GKEVFQAELSVIGRI---------NHMNLVRIWGFCSEG---------SHRLLVSEYVEN--GSLANILFSEGGNIL--------------------------LDWEGRFNIALGVAKGLAYLHHECLE------------WVIHCDVKPENILLDQAF---------EPKITDFGLVKLLNRGGSTQ--------------NVSHVRGTLGYIAPEWV------SSLPITA-KVDVYSYGV-VLLELLT-GTRVSELV------GGTDEVHSMLRKLVRMLSAKLEGEEQSW-----------IDG-YLDSKLNRPVNYV-----QARTLIK-LAVSCLEEDRSKRPTMEHA---------VQTL
PRO25      YAESRILGQGGQGTVYKGILP---------------DNSIVAIKKARLGDSSQ------------VEQQFINEVLVLPQI---------NHRNVVKLLGCCLET---------EVPLLVYEFITN--GTLFDHLHGSMINSS--------------------------LTWEHRLKIAIEVAGTLAYLHSSASI------------PILHRDIKTANILLDVNL---------TAKVADFGASRLIPMDKEE---------------LETMVQGTLGYLDPEYY------NTGLLNE-KSDVYSFGV-VLMELLS-GQKALCF-------KRPQSSKHLVSYFATAT--KENR----------------LDE-IIGGEVMNEDNLK-----EIQEAAR-IAAEC-TTNGRGRPRMKEV---------AAKL
TMKL1      NATGQVMEKTSYGTVYKAKLS---------------DGGNIALRLLREGTCK-------------DRSSCLPVIRQLGRI---------RHENLVPLRAFYQGKR--------GEKLLIYDYLPN--ISLHDLLHESKPRKPA-------------------------LNWARRHKIALGIARGLAYLHTGQEV------------PIIHGNIRSKNVLVDDFF---------FARLTEFGLDKIMVQAVAD---------------EIVSQAKSDGYKAPELH------KMKKCNP-RSDVYAFGI-LLLEILM-GKKPGKS-------GRNGNEFVDLPSLVKAAVLEETTMEV-------------FDLEAMKGIRSPMEE-------GLVHALK-LAMGCCAPVTTVRPSMEEV---------VKQL
pelle      WSPDNRLGQGGFGDVYRGKWK----------------QLDVAIKVMNYRSPNIDQKMV-------ELQQSYNELKYLNSI---------RHDNILALYGYSIKG---------GKPCLVYQLMKG--GSLEARLRAHKAQNPLPA-----------------------LTWQQRFSISLGTARGIYFLHTARGT------------PLIHGDIKPANILLDQCL---------QPKIGDFGLVREGPKSLDAVV-------------EVNKVFGTKIYLPPEFR------NFRQLST-GVDVYSFGI-VLLEVFT-GRQVTDRVP-----ENETKKNLLDYVKQQWRQNRMELL----------------EKHLAA-----PMGKELD---MCMCAIE-AGLHCTALDPQDRPSMNAVLKRF-----EPFV

OPK Group XI

PSK/PTK "mixed lineage" leucine zipper domain family


MLK1       LTLEEIIGIGGFGKVYRAFWIG----------------DEVAVKAARHDPDEDISQ---------TIENVRQEAKLFAML---------KHPNIIALRGVCLKE---------PNLCLVMEFARG--GPLNRVLSGKR------------------------------IPPDILVNWAVQIARGMNYLHDEAIV------------PIIHRDLKSSNILILQKVENGDLSNK-ILKITDFGLAREWHRT----------TKMSAA--------GTYAWMAPEVI------RASMFSK-GSDVWSYGV-LLWELLT-GEVPFRGI------DGLRVAYGVAMNKLALPIPST----------------------------------------CPEPFAK-LMEDCWNPDPHSRPSFTNI---------LDQL
PTK1       LRLEEVIGIGGFGKVYRGSWRG----------------ELVAVKAARQDPDEDISV---------TAESVRQEARLFAML---------AHPNIIALKAVCLEE---------PNLCLVMEYAAG--GPLSRALAGRR------------------------------VPPHVLVNWAVQIARGMHYLHCEALV------------PVIHRDLKSNNILLLQPIESDDMEHK-TLKITDFGLAREYHKT----------TQMSAA--------GTYAWMAPEVI------KASTFSK-GSDVWSFGV-LLWELLT-GEVPYRGI------DCLAVAYGVAVNKLTLPIPST----------------------------------------CPEPFAQ-LMADCWAQDPHRRPDFASI---------LQQL

OPK Group XII

Casein kinase I family


CKIa       YKLVRKIGSGSFGDIYLAINIT--------------NGEEVAVKLESQKA---------------RHPQLLYESKLYKILQ--------GGVGIPHIRWYGQEK---------DYNVLVMDLLG---PSLEDLFNFCSRR----------------------------FTMKTVLMLADQMISRIEYVHTK---------------NFIHRDIKPDNFLMGIGRHCN------KLFLIDFGLAKKYRDNRTRQHIPYR---------EDKNLTGTARYASINAHL-----GIEQSR--RDDMESLGY-VLMYFNR-TSLPWQGLKAA{6}EKISEKKMSTPVEVLCKGFPAEFAM------------------------------------YLNYCRG-LRFEEAPDYMYLRQLFRILFRTLNHQY-DYTF
CKIb       YKLVREIGFGSFGHVYLAIDLT--------------NHEQVAVKLESENT---------------RQPRLLHEKELYNFLQ--------GGVGIPQIRWYGQET---------DYNVLVMDLLG---PSLEDLFNFCSRR----------------------------FSMKTVLMLADQMISRIEYVHSR---------------NLIHRDIKPDNFLMGTGPQWK------KLFLVDFGLAKKYRDNRTGQHIPHR---------SGKSFIGTPFCASISAHL-----GIEQSR--RDDMESIGY-VLMYFNR-GSLPWQGLKAA{6}EKISEMKMTTPVDVLCKGFPAEFAM------------------------------------YLKYCLR-LSFEEAPDYRYLRQLFRILFRKLSYQH-DYAF
CKId       YRLGRKIGSGSFGDIYLGTDIA--------------AGEEVAIKLECVKT---------------KHPQLHIESKIYKMMQ--------GGVGIPTIRWCGAEG---------DYNVMVMELLG---PSLEDLFNFCSRK----------------------------FSLKTVLLLADQMISRIEYIHSK---------------NFIHRDVKPDNFLMGLGKKGN------LVYIIDFGLAKKYRDARTHQHIPYR---------ENKNLTGTARYASINTHL-----GIEQSR--RDDLESLGY-VLMYFNL-GSLPWQGLKAA{6}ERISEKKMSTPIEVLCKGYPSEFAT------------------------------------YLNFCRS-LRFDDKPDYSYLRQLFRNLFHRQGFSY-DYVF
YCK1       YKIGKKIGEGSFGVLFEGTNMI--------------NGVPVAIKFEPRKT---------------EAPQLRDEYKTYKILN--------GTPNIPYAYYFGQEG---------LHNILVIDLLG---PSLEDLFDWCGRK----------------------------FSVKTVVQVAVQMITLIEDLHAH---------------DLIYRDIKPDNFLIGRPGQPDAN----NIHLIDFGMAKQYRDPKTKQHIPYR---------EKKSLSGTARYMSINTHL-----GREQSR--RDDMEALGH-VFFYFLR-GHLPWQGLKAP{6}EKIGEKKRSTNVYDLAQGLPVQFGR------------------------------------YLEIVRS-LSFEECPDYEGYRKLLLSVLDDLGETA-DGQY
YCK2       YKIGKKIGEGSFGVLFEGTNMI--------------NGLPVAIKFEPRKT---------------EAPQLKDEYRTYKILA--------GTPGIPQEYYFGQEG---------LHNILVIDLLG---PSLEDLFDWCGRR----------------------------FSVKTVVQVAVQMITLIEDLHAH---------------DLIYRDIKPDNFLIGRPGQPDAN----KVHLIDFGMAKQYRDPKTKQHIPYR---------EKKSLSGTARYMSINTHL-----GREQSR--RDDMEAMGH-VFFYFLR-GQLPWQGLKAP{6}EKIGEKKRLTNVYDLAQGLPIQFGR------------------------------------YLEIVRN-LSFEETPDYEGYRMLLLSVLDDLGETA-DGQY
HRR25      FRIGRKIGSGSFGDIYRGTNLI--------------SGEEVAIKLESIRS---------------RHPQLDYESRVYRYLS--------GGVGIPFIRWFGREG---------EYNAMVIDLLG---PSLEDLFNYQHRR----------------------------FSFKTVIMLALQMFCRIQYIHGR---------------SFIHRDIKPDNFLMGVGRRGS------TVHVIDFGLSKKYRDFNTHRHIPYR---------ENKSLTGTARYASVNTHL-----GIEQSR--RDDLESLGY-VLIYFCK-GSLPWQGLKAT{6}DRIMEKKLNVSVETLCSGLPLEFQE------------------------------------YMAYCKN-LKFDEKPDYLFLARLFKDLSIKLEYHN-DHLF

OPK Group XIII

PKN prokaryotic protein kinase family


PKN1       FRLVRRLGRGGMGAVYLGEHVS--------------IGSRVAVKVLHAHLTMYPE----------LVQRFHAEARAVNLI---------GHENIVSIFDMDATP---------PRPYLIMEFLDG--APLSAWVGTP-------------------------------LAAGAVVSVLSQVCDALQAAHAR---------------GIVHRDLKPDNIFLVRRNGNAP-----FVKVLDFGIAKLADLHMPQT--------------HAGIIVGTPEYMAPEQS------LGRGVDG-RADLYALGV-IAYQLLT-GRLPFNDE------GLAAQLVAHQLRPPPPPSSVYPA--------------------------------------VSAALEH-VILRALAKKPEDRYASIAAFRNAL----QVAL
PKN2       FRVLRPLGSGGMGEVYLGEQVS--------------LGRKVAIKVLHHDLHAQAG----------MAERFKPEARLLSAV---------EHPAVVRIVDFGESG---------DHACLVMEFVEG--ESLYDVLTPGP------------------------------MPPGRALPLLQQLAEGLAAIHDK---------------GIIHRDLKPENVFISKSARGE------QARLLDFGIARLVEPDAASSVS------------QIGVVLGTPEYLSPEQA------VGAKVDT-RSDLYSFGV-LTYRVLS-GRLPFDGP------LPRNFLSQHASAAPLPLDRAAPTLS------------------------------------RYVGLLS-LVMRLLEKDASKRPQSAHELADAL----AAAH

OPK Other (each with no close relatives)


IRE1       VVSEKILGYGSSGTVVFQGSF---------------QGRPVAVKRMLID----------------FCDIALMEIKLLTESD--------DHPNVIRYYCSETTD---------RFLYIALELCNL---NLQDLVESKNVSDENLKL----------------------QKEYNPISLLRQIASGVAHLHSL---------------KIIHRDLKPQNILVSTSSRFTADQ{7}RILISDFGLCKKLDSGQSSFRT------------NLNNPSGTSGWRAPELL-E{24}TKRRLTR-SIDIFSMGC-VFYYILSKGKHPFGDKY-----SRESNIIRGIFSLDEMKCLHDRS--------------------------------------LIAEATD-LISQMIDHDPLKRPTAMKVLR-------HPLF
CDC7       YKLIDKIGEGTFSSVYKAKDITGKITKKFASHFWNYGSNYVALKKIYVTS---------------SPQRIYNELNLLYIMT--------GSSRVAPLCDAKRVR---------DQVIAVLPYYPH--EEFRTFYRD--------------------------------LPIKGIKKYIWELLRALKFVHSK---------------GIIHRDIKPTNFLFNLELG--------RGVLVDFGLAEAQMDYKSMISSQNDYANDN{72}ANANRAGTRGFRAPEVLM-----KCGAQST-KIDIWSVGV-ILLSLLG-RRFPMFQSL-----DDADSLLELCTIFGWKELRKCAALHGLGFEASGLI{58}KTNMDAVDAYELKKYQEEIWS-DHYWCFQ-VLEQCFEMDPQKRSSAEDLLK-------TPFF
COT        NIGSDFIPRGAFGKVYLAQDIK--------------TKKRMACKLIPVD----------------QFKPSDVEIQACF-----------RHENIAELYGAVLWG---------ETVHLFMEAGEG--GSVLEKLESCGP-----------------------------MREFEIIWVTKHVLKGLDFLHSK---------------KVIHHDIKPSNIVFMST----------KAVLVDFGLSVQMTEDVY----------------FPKDLRGTEIYMSPEVI------LCRGHST-KADIYSLGA-TLIHMQT-GTPPWVK-------RYPRSAYPSYLYIIHKQAPPLEDIADD----------------------------------CSPGMRE-LIEASLERNPNHRPRAADLLK-------HEAL
YpkA       VAETDKFAEGESHISIIETK----------------DKQRLVAKIERSIAE--------------GHLFAELEAYKHIYKTAG------KHPNLANVHGMAVVPYGNRKEEALLMDEVDGWRCSDTLRTLADSWKQGKINSE--------------------------AYWGTIKFIAHRLLDVTNHLAKA---------------GVVHNDIKPGNVVFDRASG--------EPVVIDLGLHSRS---------------------GEQPKGFTESFKAPELGV-----GNLGASE-KSDVFLVVS-TLLHCIE-GFEKNPEIKP----NQGLRFITSEPAHVMDENGYPIHRPGIAG--------------------------------VETAYTR-FITDILGVSADSRPDSNEARL-------HEFL

ninaC      FEIYEEIAQGVNAKVFRAKELD--------------NDRIVALKIQHYD----------------EEHQVSIEEEYRTLRDYC------DHPNLPEFYGVYKLSKPNGP----DEIWFVMEYCAG--GTAVDMVNKLLKLDRR-------------------------MREEHIAYIIRETCRAAIELNRN---------------HVLHRDIRGDNILLTKNG---------RVKLCDFGLSRQVDSTLG----------------KRGTCIGSPCWMAPEVVSAME--SEPDITV-RADVWALGI-TTIELAD-GKPPFADMHPT---RAMFQIIRNPPPTLMRPTN------------------------------------------WSQQIND-FISESLEKNAENRPMMVEMVE-------HPFL
CDC15      YHLKQVIGRGSYGVVYKAINKH--------------TDQVVAIKEVVYENDE-------------ELNDIMAEISLLKNL---------NHNNIVKYHGFIRKS---------YELYILLEYCAN--GSLRRLISRSSTG----------------------------LSENESKTYVTQTLLGLKYLHGE---------------GVIHRDIKAANILLSADN---------TVKLADFGVSTIVNS-------------------SALTLAGTLNWMAPEIL------GNRGAST-LSDIWSLGA-TVVEMLT-KNPPYHN-------LTDANITTAVENDTYYPPSS-----------------------------------------FSEPLKD-FLSKCFVKNMYKRPTADQLLK-------HVWI

chk1+      YHIGREIGTGAFASVRLCYDDN---------------AKIYAVKFVNKKHATSCMNAGV------WARRMASEIQLHKLCN--------GHKNIIHFYNTAENP---------QWRWVVLEFAQG--GDLFDKIEPDVG-----------------------------IDEDVAQFYFAQLMEGISFMHSK---------------GVAHRDLKPENILLDYNG---------NLKISDFGFASLFSYKGKSR--------------LLNSPVGSPPYAAPEIT------QQ-YDGS-KVDVWSCGI-ILFALLL-GNTPWDEA------ISNTGDYLLYKKQCERPSYHPWNL-------------------------------------LSPGAYS-IITGMLRSDPFKRYSVKHVVQ-------HPWL
NPR1       IKTGADLGAGAGGSVKLAQRIS--------------DNKIFAVKEFRTKFENESKRD--------YVKKITSEYCIGTTL---------NHPNIIETIEIVYEN---------DRILQVMEYCEY---DLFAIVMSNK------------------------------MSYEEICCCFKQILTGVQYLHSI---------------GLAHRDLKLDNCVINEKG---------IVKLIDFGAAVVFSYPFSKNLV------------EASGIVGSDPYLAPEVCI-----FAKYDPR-PVDIWSSAI-IFACMIL-KKFPWKIPKLR---DNSFKLFCSGRDCDSLSSLVTRTPDPPSYDESHSTEKKKPESSSNNVSDPNNVNIGPQ{5}LPEETQH-IVGRMIDLAPACRGNIEEIME-------DPWI
TSL        YALLNLLGKGGFSEVYKAYDLV--------------DHRYVACKLHGLNAQWSEEKKQS------YIRHANRECEIHKSL---------VHHHIVRLWDKFHIDM--------HTFCTVLEYCSG--KDLDAVLKATSN-----------------------------LPEKEARIIIVQIVQGLVYLNKKSQ-------------KIIHYDLKPGNVLFDEFG---------VAKVTDFGLSKIVEDNVGSQGME-----------LTSQGAGTYWYLPPECFELN---KTPMISS-KVDVWSVGV-LFYQMLF-GKRPFGHDQSQERILREDTIIKAKKVEFPVTRPA-----------------------------------------ISNEAKD-LIRRCLTYNQEDRPDVLTMAQ-------DPYL
PIM1       YQVGPLLGSGGFGSVYSGIRVS--------------DNLPVAIKHVEKDRISDWGELP-------NGTRVPMEVVLLKKVSS-------GFSGVIRLLDWFERP---------DSFVLILERPEPV-QDLFDFITERGA-----------------------------LQEELARSFFWQVLEAVRHCHNC---------------GVLHRDIKDENILIDLNRG--------ELKLIDFGSGALLKDT------------------VYTDFDGTRVYSPPEWIR-----YHRYHGR-SADVWSLGI-LLYDMVC-GDIPF---------EHDEEIIRGQVFFVDGRQR------------------------------------------VSSECQH-LIRWCLALRPSDRPTFEEIQN-------HPWM
ran1+      LRFVSIIGAGAYGVVYKAEDIY--------------DGTLYAVKALCKDGLNEK-----------QKKLQARELALHARVS--------SHPYIITLHRVLETE---------DAIYVVLQYCPN--GDLFTYITEKKVYQ---------------------------GNSHLIKTVFLQLISAVEHCHSV---------------GIYHRDLKPENIMVGNDGN--------TVYLADFGLATTEPY-------------------SSDFGCGSLFYMSPECQRE{24}SSSFATA-PNDVWALGI-ILINLCC-KRNPWK--------RACSQTDGTYRSYVHNPSTLLSILP------------------------------------ISRELNS-LLNRIFDRNPKTRITLPELST-------LVSN
TTK        YSILKQIGSGGSSKVFQVLNE---------------KKQIYAIKYVNLEEADNQ-----------TLDSYRNEIAYLNKLQ--------QHSDKIIRLYDYEITD--------QYIYMVMECGNI---DLNSWLKKKKS-----------------------------IDPWERKSYWKNMLEAVHTIHQH---------------GIVHSDLKPANFLIVDG----------MLKLIDFGIANQMQPDTTSV--------------VKDSQVGTVNYMPPEAIKDM{6}GKSKISP-KSDVWSLGC-ILYYMTY-GKTPFQQII-----NQISKLHAIIDPNHEIEFPDIP---------------------------------------EKDDLQD-VLKCCLKRDPKQRISIPELLA-------HPYV
ELM1       YTLGVSAGSGQFGYVRKAYSST--------------LGKVVAVKIIPKKPWNAQQYSVNQV{13}TTNMSGNEAMRLMNIEKCRWE{8}NNVHIVRLIECLDSPFS-------ESIWIVTNWCSL--GELQWKRDDDEDILPQWKKIVISNC----------------SVSTFAKKILEDMTKGLEYLHSQ---------------GCIHRDIKPSNILLDEEEK--------VAKLSDFGSCIFTPQSLPFSDANFEDCFQR----ELNKIVGTPAFIAPELCHLG{4}DFVTDGF-KLDIWSLGV-TLYCLLY-NELPFFGENEF---ETYHKIIEVSLSSKIN---------------------------------------------GNTLNDL-VIKRLLYKDVTLRISIQDLVK-------VLSR
VPS15      VHYVSQLNSSRFLKTCKALDPN----------------GEIVIKVFIKPKDQYSLRP--------FLQRIRAQSFKLG-----------QLPHVLNYSKLIETN---------RAGYMIRQHLKN---NLYDRLSLRPY-----------------------------LQDIELKFIAFQLLNALKDIHNL---------------NIVHGDIKTENILVTSWN---------WCILTDFAAFIKPVYLPEDNPGEFLF--------YFDTSKRRTCYLAPERFNSK{7}NNGRLTK-EMDIFSLGC-VIAEIFA-EGRPIFNL------SQLFKYKSNSYDVNREFLMEEM---------------------------------------NSTDLRN-LVLDMIQLDPSKRLSCDELLNKYR----GIFF
YKL516     WKKVRPIGSGNFSTVLLYELMDQSNP----------KLKQVAVKRLKYPEELSNVEQINTSL{8}LENSLTRELQVLKSL---------NHPCIVKLLGINNPIFVTSK{14}PPCDMIMSYCPA--GDLLAAVMARNGR----------------------------LEAWLIQRIFTEVVLAVKYLHEN---------------SIIHRDLKLENILLKYSFDDINS{11}FIELADFGLCKKIENNE-----------------MCTARCGSEDYVSPEILM-----GVPYDGH-LSDTWALGV-ILYSLFE-DRLPFDPPPNA{7}ATSHRIARFDWRWYRLSD-------------------------------------------YKTNVGK-QIVENTLTRKNQRWSINEIYE-------SPFV

c-mos      VCLLQRLGAGGFGSVYKATYRG----------------VPVAIKQVNKCTKNRLA----------SRRSFWAELNVARL----------RHDNIVRVVAASTRTPAGSN----SLGTIIMEFGGN--VTLHQVIYGAAGHPEGDAGEPHCRTGGQ-------------LSLGKCLKYSLDVVNGLLFLHSQ---------------SIVHLDLKPANILISEQD---------VCKISDFGCSEKLEDLLCFQT-------------PSYPLGGTYTHRAPELL------KGEGVTP-KADIYSFAI-TLWQMTT-KQAPYS--------GERQHILYAVVAYDLRPSLSAAVFEDSL---------------------------------PGQRLGD-VIQRCWRPSAAQRPSARLLLV-------DLTS
Pstk1      LIQKKKIGEGTFGVVYKGEFKG----------------NSVAIKRMKPKINDNS-----------SEIEFRKEVEMLEKF---------RCNYIIHFYGAVIIQ---------DNKCMVTEYAKY--GSVQKMIESKPSNS---------------------------LSKSIKIKMLLDIARGIEYLHNN---------------GILHRDIKPDNMLITSLDNDIPV----NAKLTDFGSARNINSLMTNM--------------TFTKGVGTPSFMAPEIL------KRKKYKT-AADIYSFAI-SITLYDW-ETYLTEF-------EYPWVIATFVASGHRRP-----QNN------------------------------------LPDYVYK-LICECWCDEPTNRLNIEQTIK-------QLEI

DPYK1      LEFGQTIGKGFFGEVKRGYWRE----------------TDVAIKIIYRDQFKTKS----------SLVMFQNEVGILSKL---------RHPNVVQFLGACTAGGE-------DHHCIVTEWMGG--GSLRQFLTDHFNLLE--------------------------QNPHIRLKLALDIAKGMNYLHGWTP-------------PILHRDLSSRNNILLDHNIDPKNP{8}KCKISDFGLSRLKKEQ-----------ASQMTQ--SV---GCIPYMAPEVF------KGDSNSE-KSDVYSYGM-VLFELLT-SDEPQQDM------KPMKMAHLAATESYRPPIPLT----------------------------------------TSSKWKE-ILTQCWDSNPDSRPTFKQI---------IVHL
DPYK2      IQFIQKVGEGAFSEVWEGWWKG----------------IHVAIKKLKIIGDEEQ-----------FKERFIREVQNLKKG---------NHQNIVMFIGACY-----------KPACIITEYMAG--GSLYNILHNPNSSTPKVK-----------------------YSFPLVLKMATDMALGLLHLHSI---------------TIVHRDLTSQNILLDELG---------NIKISDFGLSAEKSRE----------GSMTMTN--GGI--CNPRWRPPELTK-----NLGHYSE-KVDVYCFSL-VVWEILT-GEIPFSDL------DGSQRSAQVAYAGLRPPIPEY----------------------------------------CDPELKL-LLTQCWEADPNDRPPFTYI---------VNKL
PhyCer     IQITGSLGSGSSATVEKAVWLG----------------TPVAKKTFYGR----------------NNEDFKREVEILAEL---------CHPNITSMFCSPLYR---------RKCSIIMELMD---GDLLALMQRRLDRNEDHDSPP--------------------FSILEVVDIILQTSEGMNYLHEK---------------GIIHRDLKSMNILVKSVKVTKSEIGYVHVKVADFGLSKTKDSS----------TRYSNQT--WNR--GTNRWMAPEVIN{14}-KVPKYPL-KSDVYSFGM-VCYEVLT-GDVPFPEE------KNPNNVKRMVLEGVRPDLPAH----------------------------------------CPIELKA-LITDCWNQDPLKRPSFAVI---------CQKL
GmPK6      WTKLLDNGGGKITAVETAEEWNVDMSQLFFGL{15}KDEAVAVKIIMVPEDDGNGALASR-----LEKQFIREVTLLSRL---------HHQNVIKFSAACRKP---------PVYCIITEYLAE--GSLRAYLHKLEHQT---------------------------ISLQKLIAFALDIARGMEYIHSQ---------------GVIHRDLKPENILINEDN---------HLKIADFGIACEEASC-----------DLLA----DDP--GTYRWMAPEMI------KRKSYGK-KVDVYSFGL-ILWEMLT-GTIPYEDM------NPIQAAFAVVNKNSRPIIPSN----------------------------------------CPPAMRA-LIEQCWSLQPDKRPEFWQV---------VKIL


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Last modified Wednesday, 31 December 2069 by Anonymous