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Q: phosphoinositides: translocases?
I've noticed that a higher phosphorylated phosphoinositide (PI4,5P2)
is to some extent in the outer membrane of erythrocytes, while its
precursor PI-4P is not.
Is there evidence for a translocase now or new ideas how any why
PIP2 gets into the outer membrane since a spontaneous flipflop is
unlikely due to the highly negative charge of the molecule and the
size of the head group?
Are there new ideas?
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University of Tuebingen, Germany
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