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Q: phosphoinositides: translocases?

Hi all, 

I've noticed that a higher phosphorylated phosphoinositide (PI4,5P2) 
is to some extent in the outer membrane of erythrocytes, while its 
precursor PI-4P is not. 
Is there evidence for a translocase now or new ideas how any why 
PIP2 gets into the outer membrane since a spontaneous flipflop is 
unlikely due to the highly negative charge of the molecule and the 
size of the head group?

Are there new ideas?

usual disclaimers apply * This message is RNAse free - please don't touch!
Wolfgang Schechinger         
University of Tuebingen, Germany
email: wgschech@med.uni-tuebingen.de * wwWait: http://www.medizin.uni-tuebingen.de/~wgschech/start.htm