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Re: Q: phosphoinositides: translocases?

>Hi all,
>I've noticed that a higher phosphorylated phosphoinositide (PI4,5P2)
>is to some extent in the outer membrane of erythrocytes, while its
>precursor PI-4P is not.
>Is there evidence for a translocase now or new ideas how any why
>PIP2 gets into the outer membrane since a spontaneous flipflop is
>unlikely due to the highly negative charge of the molecule and the
>size of the head group?
>Are there new ideas?


Do treatments/conditions that result in appearance of PS in the outer
leaflet of the membrane increase the amount of PIP2?


James E. Ferrell, Jr., M.D., Ph.D.
Assistant Professor
Department of Molecular Pharmacology
Stanford University School of Medicine
Stanford CA  94305-5332
Phone:  650 725-0765 [PLEASE NOTE NEW AREA CODE]
Fax:  650 725-2952