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Re: Q: phosphoinositides: translocases?



>Hi all,
>
>I've noticed that a higher phosphorylated phosphoinositide (PI4,5P2)
>is to some extent in the outer membrane of erythrocytes, while its
>precursor PI-4P is not.
>Is there evidence for a translocase now or new ideas how any why
>PIP2 gets into the outer membrane since a spontaneous flipflop is
>unlikely due to the highly negative charge of the molecule and the
>size of the head group?
>
>Are there new ideas?
>
>Wolfgang

Wolfgang,

Do treatments/conditions that result in appearance of PS in the outer
leaflet of the membrane increase the amount of PIP2?

Cheers,

Jim
-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-
James E. Ferrell, Jr., M.D., Ph.D.
Assistant Professor
Department of Molecular Pharmacology
Stanford University School of Medicine
Stanford CA  94305-5332
ferrell@cmgm.stanford.edu
Phone:  650 725-0765 [PLEASE NOTE NEW AREA CODE]
Fax:  650 725-2952