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Dear Kinasers,

I gather from my reading that the heat-stable inhibitor "PKI" is a
notorious peptide inhibitor of cAMP-dependent protein kinase.  Am I correct
in my assumption that it is a sort of "pseudo-substrate"--ie does it
compete with the bona-fide substrate?  Additionally, is this inhibitor
effective under a broad range of in vitro conditions, or does one need to
take special considerations to elicit its mighty powers?  I'd be grateful
for any guidance.  Thank you!

Paul Mason.