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I have a question about immunoreceptor tyrosine-based activation motif
(ITAM) and seek for help. 
ITAM possesses two repeats of the consensus sequence Tyr-X-X-Leu/Ile
spaced by six to eight amino acids [(YXXL)-(X6-8)-(YXXL)]. It's generally
known that ITAM is involved in T-cell receptor, B-cell receptor, and Fc
receptor activation upon tyrosine phosphorylation at YXXL. My question is:
Does ITAM have a distinct cellular function that is independent of
tyrosine phosphorylation? 
Any hint is welcome.