[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
I have a question about immunoreceptor tyrosine-based activation motif
(ITAM) and seek for help.
ITAM possesses two repeats of the consensus sequence Tyr-X-X-Leu/Ile
spaced by six to eight amino acids [(YXXL)-(X6-8)-(YXXL)]. It's generally
known that ITAM is involved in T-cell receptor, B-cell receptor, and Fc
receptor activation upon tyrosine phosphorylation at YXXL. My question is:
Does ITAM have a distinct cellular function that is independent of
Any hint is welcome.