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RE: p38

p38 is activated by dual phosphorylation, if it is phosphorylated on both
sites it is active, if it is phosphorylated on only one site it is inactive.
It was not clear from your question how you determine the phosphorylation
state of p38, if you use an antibody that recognises only the dual
phosphorylated p38, then you would expect it to be active.
Hope this help you, Yair

Yair Doza
AstraZeneca R&D Charnwood
Discovery BioScience, Bakewell Road, Loughborough, Leics LE11 5RH,
Tel: +44 (0)1509 645481   Fax: +44 (0)1509 645557

-----Original Message-----
From: Brigitte Kasper [mailto:bkasper@fz-borstel.de]
Sent: 29 July 1999 15:04
To: Kinase-Diskussionsforum
Subject: p38

Dear All,

is the phosphorylation (Thr and Tyr) of p38 MAPK allways associated with
kinase activity.
Has anyone observed phosphorylation of p38 MAPK without measurable
kinase activity????

Thanks a lot.