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kinases phosphorylation site conservation

Dear Collegues,

I'd would like to know if somebody can answer an important question: 

Does a phosphorylation site on a substrate by a kinase can change among
orthologues substrates ?
(I mean If a protein is phosphorylated and activated by a kinase, does this
regulation can be seen in a orthologous systems but in a other site in the
substrate ?)

Many thanks for all informations about this.